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  • 1
    ISSN: 1432-1041
    Keywords: ramixotidine ; oesophagitis ; duodenal ulcer ; gastro-oesophageal reflux ; histamine H2-antagonist ; intragastric pH monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of the new histamine H2-receptor antagonist ramixotidine 750 mg p.o., administered at 22.00 h, on intragastric and intraoesophageal pH monitored from 22.00 h to 08.00 h, was studied in a double-blind cross-over trial in 11 duodenal ulcer patients. Placebo and ramixotidine were given to each patient on 2 consecutive days in a randomized sequence. Three patients were excluded from the intragastric pH analysis as the records on the second study day were technically inadequate. No significant carry-over or sequence effect was noted. Intragastric hydrogen ion activity was significantly lower (p=0.01) after ramixotidine than after placebo: median (range) 24 (9–100) vs 97 (27–188) mmol/l. The percentage of time with intraoesophageal pH 〈4 was less than 5% in all but three recordings, with a maximum value of 12%, and it was not significantly different after the two treatments.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 44 (1999), S. 1716-1720 
    ISSN: 1573-2568
    Keywords: SYSTEMIC SCLEROSIS ; ESOPHAGEAL PH ; ESOPHAGEAL MOTILITY ; ESOPHAGEAL CLEARANCE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Incidental clinical observations suggest thatbuffering substances may accumulate in the distalesophagus of patients with systemic sclerosis. The aimof our study was to assess if the buffering capacity of the intraesophageal milieu is increased inpatients with systemic sclerosis and if this effect canbe correlated to some pathophysiological aspects of thedisease. We recorded intraesophageal pH before and during a 10-min intraesophageal infusion ofacid (HCl 0.01 N, 1 ml/min), as well as esophagealmotility and clearance function, in 16 patients withsystemic sclerosis and 10 healthy subjects. Esophageal buffering capacity expressed as the area underthe curve of intraesophageal pH during acid infusion wassignificantly higher in the patients than in thecontrols, and this variable was directly correlated with esophageal clearing time. In conclusion,esophageal buffering capacity is increased in patientswith systemic sclerosis and is possibly the consequenceof the accumulation of buffering substances in the distal esophagus.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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