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  • 1
    Electronic Resource
    Electronic Resource
    Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis (1995)
    Springer
    Acta neurochirurgica 137 (1995), S. 207-216 
    Details
    ISSN: 0942-0940
    Keywords: Stab wound ; autoradiography ; peripheral benzodiazepine receptor ; gliosis ; PK-11195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chronological studies of the development of the peripheral benzodiazepine receptor sites were undertaken with the goal of evaluating the sensitivity of this marker for the study of the gliosis development in the injured brain. No significant increase in [3H] PK-11195 binding occurred in the rat brain stab wound one day following the puncture. A significant increase in the receptor density (Bmax) from the second day onward was observed. The Bmax reached its highest levels in the grey matter on the sixth day after a 23-gauge needle wound (8.75 ± 0.09; pmol mg-tissue−1) and on the seventh day after an 18-gauge needle wound (8.98 ± 0.31 pmol mgtissue−1). In the white matter, the Bmaxwas greatest seven days after the wound (3.42 ± 0.07; pmol mg-tissue−1; 23-gauge needle and 3.56 ±0.1 pmol mg-tissue−1 in the 18-gauge needle injury). Between 30 and 60 days after the wound, the Bmax was significantly lower than the Bmax observed between 6 and 14 days. The Bmax in the wound produced with needles was seven to eight times greater than the Bmax in the grey matter of the ipsilateral and contralateral cortices. Histological examination showed that there were no astrocytes or macrophages in the stab wound one day after the lesion. However, the glial fibrillary acidic protein positive cells and macrophages appeared on D3 after an injury. Gliosis, as measured by the PK-11195 binding, was also observed in the remote contralateral cortex. Data shows that PK-11195 binding is a very sensitive method of evaluating brain injury and could be of great value in studying progressive injuries in the living human brain in conjunction with positron emission tomography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187195
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 11C-labelled BCNU and SarCNU in gliomas studied by PET (1991)
    Springer
    Journal of neuro-oncology 10 (1991), S. 47-55 
    Details
    ISSN: 1573-7373
    Keywords: nitrosoureas ; glioma ; BCNU ; SarCNU ; PET ; chemotherapy ; brain tumor ; BBB
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper describes the study of the pharmacodynamics of two 11C-labelled nitrosoureas, 1,3-bis-(2-chloroethyl) nitrosourea (BNCU) and sarcosinamide chloroethylnitrosourea (SarCNU), both labelled in the carbonyl position. Distribution of the radioactivity as measured by positron emission tomography was compared to the distribution of radioactivity observed after injection of 68Ga-EDTA, this being used as an indicator of the blood-brain barrier integrity around the brain tumor. Data suggest that the new nitrosourea, SarCNU, most likely enters brain tissue by different mechanism(s) than BCNU, which enters by diffusion. Data also indicate that use of SarCNU may result in a better tumor to brain ratio than BCNU.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00151246
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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