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  • Thorax  (1)
  • antimycotic drug  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 33 (1987), S. 531-534 
    ISSN: 1432-1041
    Keywords: ketoconazole ; pharmacokinetics ; antimycotic drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the pharmacokinetics of the anti-mycotic ketoconazole in seven patients who took it for 1–6 months at a dose of 200 mg daily. The mean elimination half-life of the drug was 3.3 h, and although the ketoconazole was given only once daily, a satisfactory clinical response was obtained in all seven individuals. Only a small fraction of the absorbed drug (mean 0.22%) was excreted unchanged in the urine, suggesting almost complete metabolism. Our results support the concept that anti-mycotic activity in the tissues continues after the plasma drug concentration has fallen below a critical level. Our results also support the concept of a change in pharmacokinetics with chronic dosing.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 22 (1994), S. 692-706 
    ISSN: 1573-9686
    Keywords: Magnetic resonance imaging ; Segmental parameters ; Mass ; Center of mass ; Moment of inertia ; Trunk ; Thorax ; Abdomen ; Pelvis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The purpose of this study was to evaluate the segmental parameters of the human trunk of malesin vivo using magnetic resonance imaging (MRI). In addition, the efficacy of volumetric estimation and existing prediction formulas to produce segmental properties similar to those produced by MRI was evaluated. As opposed to finding one representative normal value for these parameters, a range of normal values was defined. For instance, the average trunk mass was 42.2%±3.5% (x±SD) of body mass, but values ranged from 35.8% to 48.0%. To account for segment parameters more accurately, specific anthropometric measures need to be considered in addition to overall measures of body height and mass. These specific measures included segment length, circumference, width, and depth. Studies reporting general percentages based on height and/or mass were found to be inadequate predictors of segmental parameters of the trunk compared with MRI estimates. Volumebased estimates, which assume a uniform density distribution within a segment, were found to correspond closely to MRI values except for the thorax. However, the use of density values reflective of the livingin vivo state would likely alleviate this disparity, thus indicating that the volumetric technique may be effective for deriving segmental parameters for large segments of the trunk. Future research should adopt noninvasive techniques such as MRI and/or volumetric estimation to enhance the predictability of segmental parameters of the body for specific population groups characterized by gender, developmental age, body type, and fitness level. Further efforts should be made to establish standardized boundary definitions for trunk segments to avoid unnecessary confusion, from which substantial errors may be introduced into biomechanical linked-segment analyses of human movement.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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