ISSN:
1435-1463
Schlagwort(e):
Keywords: Substance P
;
cerebrospinal fluid
;
amyotrophic lateral sclerosis.
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary. To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s007020050214
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