ISSN:
1573-6830
Keywords:
apoptosis
;
impulse enhancer
;
sigma receptor
;
neuroprotection
;
(+)-pentazocine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract SUMMARY 1. The rapid cell death of cortical neurons in serum-free culture was rescued by the condition medium from the high-density culture, but not by brain-derived neurotrophic factor or basic fibroblast growth factor. 2. Similar rescue was observed by the addition of (−)BPAP, an impulse enhancer, and (+)-pentazocine, a sigma receptor agonist. These actions were blocked by BD1063, a sigma receptor antagonist. 3. (−)BPAP showed a weak displacement activity in the [3H]pentazocine binding to synaptic membranes from rat cerebral cortex. 4. These findings suggest that (−)BPAP and (+)-pentazocine have unique survival activity on cortical neurons through sigma receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007050808754
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