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  • breast cancer  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Androstenedione conversion in lymphocytes infiltrating breast tumor tissue (1997)
    Springer
    Bulletin of experimental biology and medicine 124 (1997), S. 1008-1010 
    Details
    ISSN: 1573-8221
    Schlagwort(e): lymphocytes ; lymphocytic infiltration ; breast cancer ; estrogens
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Lymphocytes infiltrating tumor tissue are capable of androstenedione conversion, which was assessed from3H2O release from tritium-labeled androgen precursor of estrogens 1β-androstenedione. This capacity is higher in menopausal patients than in patients of reproductive age. A tendency to a positive correlation between the intensity of androstenedione conversion in lymphocytes and aromatase activity in tumor tissue is revealed. No relationship between androstenedione conversion in lymphocytes and contamination of the isolated cell suspension with tumor cells is detected.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02446847
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Activity of aromatase in breast cancer tissue: Role of the cell substrate (1995)
    Springer
    Bulletin of experimental biology and medicine 120 (1995), S. 1042-1045 
    Details
    ISSN: 1573-8221
    Schlagwort(e): aromatase ; breast cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The activity of aromatase (estrogen synthetase) in tumor tissue of breast cancer patients was investigated by biochemical and immunohistochemical methods. The detection of medium or high enzyme activity in tumor tissue was virtually the same for both methods. According to immunohistochemical analysis, aromatase activity was localized mainly in malignant epithelial cells, being reliably higher in the tumors of patients in menopause than in those whose cycle was intact. Doubts about the biological role of aromatase in breast cancer tissue may be dispelled if the tissue topography of the enzyme and the individual ratio of epithelial to stromal cellular elements in individual neoplasms of the breast are taken into account.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02444980
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
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