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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Ethanol on Uterotropic Action of Estrogens (2000)
    Springer
    Bulletin of experimental biology and medicine 130 (2000), S. 976-978 
    Details
    ISSN: 1573-8221
    Keywords: estrogens ; ethanol ; DNA damage ; modifiers of estrogen-induced carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Female rats aging 3 months at the beginning of experiments received 5 or 15% ethanol and then were subjected to bilateral ovariectomy 2 weeks before end of the experiment. During the last 11 days they were daily injected intramuscularly with 2 μg estradiol. Drinking of 5% ethanol combined with injections of estrogens induced DNA damage in the uterus detected by comet assay and abolished induction of progesterone receptors, changes in peroxidase activity, proliferation index, endometrium thickness, and other indices reflecting the hormonal effect of estradiol on the uterus. Drinking of 15% ethanol was accompanied by an increase in DNA-damaging effects of estrogens and a decrease in their hormonal uterotropic effects. It is concluded that unlike tobacco smoking, drinking of moderate ethanol concentrations modifies primarily genotoxic, but not the hormonal effect of estrogens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1002818008246
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Androstenedione conversion in lymphocytes infiltrating breast tumor tissue (1997)
    Springer
    Bulletin of experimental biology and medicine 124 (1997), S. 1008-1010 
    Details
    ISSN: 1573-8221
    Keywords: lymphocytes ; lymphocytic infiltration ; breast cancer ; estrogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Lymphocytes infiltrating tumor tissue are capable of androstenedione conversion, which was assessed from3H2O release from tritium-labeled androgen precursor of estrogens 1β-androstenedione. This capacity is higher in menopausal patients than in patients of reproductive age. A tendency to a positive correlation between the intensity of androstenedione conversion in lymphocytes and aromatase activity in tumor tissue is revealed. No relationship between androstenedione conversion in lymphocytes and contamination of the isolated cell suspension with tumor cells is detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446847
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of audiogenic seizures on activity of H and M forms of lactate dehydrogenase in neurons and neuroglia in various parts of the central nervous system (1975)
    Springer
    Bulletin of experimental biology and medicine 80 (1975), S. 1197-1199 
    Details
    ISSN: 1573-8221
    Keywords: neuron ; neuroglia ; audiogenic seizures ; lactate dehydrogenase isozymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cytospectrophotometric analysis showed that the ratio between activities of aerobic H forms of lactate dehydrogenase (LD) and the activity of its anaerobic M forms in cerebral cortical neurons and cerebellar Purkinje cells and also in their glial satellite cells of rats of the Krushinskii-Molodkina and Wistar strains is higher than in motoneurons in the anterior horns of the spinal cord and their perineuronal glia. In Krushinskii-Molodkina rats (with genetically determined high sensitivity to audiogenic seizures) epileptiform audiogenic seizures were accompanied by marked activation of both H and M forms of LD in the cortical neurons but by absence of changes in the perineuronal glia. In the spinal motoneurons, on the other hand, the activity of all forms of LD was unchanged, whereas in the neuroglial cells surrounding these neurons activity of the H forms of LD was definitely increased. During the seizures an increase in activity of M forms of LD was found in the cerebellar Purkinje cells but a decrease in their activity in the glial satellite cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00833159
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Secretion of interleukin-1\ and tumor necrosis factor by blood mononuclears in patients with breast cancer: Effects of body weight (Composition), age, and tobacco smoking (1996)
    Springer
    Bulletin of experimental biology and medicine 121 (1996), S. 83-85 
    Details
    ISSN: 1573-8221
    Keywords: cytokines ; cancer ; body composition ; tobacco smoking ; age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Examinations of patients with breast cancer and mammary fibroadenomatosis suggest a relationship between the secretion of interleukin-1β and tumor necrosis factor by blood mononuclears, on the one hand, and patients' age, body weight, and body fat, on the other. A modifying (discoordinating) role of tobacco smoking in the realization of this process is noted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02445714
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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