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  • clinical pharmacology  (2)
  • pharmacokinetics  (2)
  • elderly patients  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of naproxen in elderly patients (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 463-468 
    Details
    ISSN: 1432-1041
    Keywords: naproxen ; osteoarthritis ; elderly patients ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than in the controls (60.1 vs. 43.3 µ g · ml−1). The AUC (0–24) was significantly higher in the elderly subjects only when normalized for body weight (9.1 vs. 5.4 µg·ml−1·h kg−1 p⩽0.02). The AUC was significantly higher in the elderly group compared to the control group also in the normalized form. The apparent clearance of naproxen was reduced in the elderly compared to the control patients (315 vs. 628 ml·h−1). The percentage protein binding of naproxen was the same in both groups (99.8%) but the free concentration of naproxen was significantly higher in the elderly patients than in the control patients (141 vs. 89.8 ng·ml−1). Although there was no excess of side effects in the elderly patients it is suggested that when naproxen is given to elderly patients, therapy should be started at the lower end of the dosage range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613525
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 681-684 
    Details
    ISSN: 1432-1041
    Keywords: ivermectin ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Administration of 12-mg doses of ivermectin (H2B1a) to 12 healthy volunteers in the form of tablets, capsules, and alcoholic oral solution showed the solution to have approximately twice the systemic availability as either of the solid forms, as evidence both by the maximum concentrations of drug attained in plasma and by the corresponding areas under the plasma concentration vs time curves. However, the two solid formulations showed similar systemic availability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637608
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical pharmacology and primary health care in Europe — a gap to bridge (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 315-318 
    Details
    ISSN: 1432-1041
    Keywords: primary health care ; clinical pharmacology ; prescription habits ; improved drug therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A group of senior European clinical pharmacologists presents a position paper on the possible role of clinical pharmacology (CP) in bridging the gap between academic drug evaluation and drug prescribing in primary health care (PHC). As a teaching, research and service discipline CP has developed in academic or other major hospitals while 80% of all drugs are prescribed in PHC. CP therefore has to extend its functions to PHC. Examples are given of how joint ventures between clinical pharmacologists and PHC physicians may improve the quality of drug research and increase the clinical relevance of drug information in PHC, thereby contributing towards rational drug utilization in PHC. Colleagues in PHC are invited to respond to this call for collaboration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315567
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  • 4
    Electronic Resource
    Electronic Resource
    The teaching and organisation of clinical pharmacology in European medical schools (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 101-105 
    Details
    ISSN: 1432-1041
    Keywords: clinical pharmacology ; European Medical Schools ; teaching ; organization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A World Health Organisation (European Regional Office) working party has been established to review the progress of clinical pharmacology in European countries. As part of this review a questionnaire on the teaching of chlinical pharmacology was sent to the Deans of all 350 medical schools in the region. Very few replies were received from U.S.S.R., Greece and Portugal and these countries' returns were not analysed further. The overall compliance rate (excluding these countries) was 82% with a figure of 84% from Western Europe and 74% from Eastern Europe. An average time of 96 h (range 0–320) was devoted to pharmacology teaching in the medical curriculum in Western Europe with 124 (0–240) h in Eastern Europe. In contrast 28 h (0–210) was devoted to clinical pharmacology teaching in Western Europe and 27 h (0–90) in Eastern Europe. On average in Western Europe each medical school had 2 individuals trained in clinical pharmacology with 1.3 posts in the subject and the figures for Eastern Europe were 2.3 and 1.1 respectively. However these figures hide a wide variance in the teaching of clinical pharmacology. Particularly in Western Europe there are a number of medical schools in Italy, Spain and the Federal Republic of Germany (FRG) where clinical pharmacology is not taught and there is a dearth of individuals trained in the subject. Every effort to encourage clinical pharmacology and its teaching should be made, particularly in these countries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265965
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    Paper (German National Licenses)
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