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  • 1
    Electronic Resource
    Electronic Resource
    Mucosal concentrations of interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor-α in pelvic ileal pouches (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 1525-1531 
    Details
    ISSN: 1573-2568
    Keywords: ulcerative colitis ; pelvic ileal pouch ; cytokines ; pouchitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) were determined by solid-phase ELISA in tissue homogenates of mucosal biopsy specimens obtained from pelvic ileal pouches in 13 patients with pouchitis (reservoir ileitis) and 17 with pouches without pouchitis. Normal ileal mucosa was used as a control. IL-1β was detected in all tissue homogenates from patients with pouchitis compared with only 29% from pouches without pouchitis and none from controls. IL-6 and IL-8 were present in all pouchitis specimens, in 70% of the specimens from nonpouchitis and only 30% of specimens from controls. TNF-α was undetectable in all specimens examined. The concentrations of IL-1β, IL-6, and IL-8 were significantly greater (P〈0.001) in biopsy specimens from pouchitis compared to those from pouches without pouchitis or normal ileal mucosa and in patients with pouchitis tissue levels of IL-1β significantly correlated with IL-6 (P〈0.05) and IL-8 (P〈0.01). Furthermore IL-1 and IL-8 levels were significantly higher in tissue specimens from nonpouchitis pouches than in those from normal ileal mucosa (P〈0.02). These results suggest that an enhanced cellular immunity operatesin vivo at the mucosal level in pouchitis as in the case of ulcerative colitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088059
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generation (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 174-178 
    Details
    ISSN: 1573-2568
    Keywords: sulfasalazine ; 5-aminosalicylic acid ; olsalazine ; superoxide radical ; chemiluminescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thein vitro antioxidant capacity of sulfasalazine (SASP), its metabolites (SP, 5-SSA), and olsalazine (OAZ), was studied by evaluating their effects on superoxide (O2 − •) production. Assay systems were the xanthine-xanthine oxidase (X/XOD) reaction and phorbol myristate acetate (PMA)-activated polymorphonuclear leukocytes (PMNs), using the cytochromec (cyt-c) reduction assay and a luminol-dependent chemiluminescence method. 5-ASA, SASP, and OAZ showed a dose-dependent scavenger effect in both O2 − • generating systems, 5-ASA being the most powerful (〉50% of inhibition in the PMNs system and 〉70% in the X/XOD system at 10 μM concentration). SP had an inhibitory effect only in the PMNs system but did not modify the activity of xanthine oxidase, thus excluding a scavenger action. These data suggest that the scavenger effect of 5-ASA, SASP, and OAZ may be an important mechanism of action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01300752
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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