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  • diabetic pregnancy  (1)
  • drug metabolism  (1)
  • duodenal ulcer patients  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Glycosylated haemoglobin in cord blood following normal and diabetic pregnancies (1983)
    Springer
    Diabetologia 25 (1983), S. 482-485 
    Details
    ISSN: 1432-0428
    Keywords: Glycosylated haemoglobin ; cord blood ; diabetic pregnancy ; normal pregnancy ; diabetes ; pregnancy ; diabetic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cord and maternal blood samples were obtained at delivery in 25 normal and 14 diabetic pregnancies (13 insulindependent, one gestational). Total glycosylated haemoglobin, measured by the colorimetric thiobarbiturate method (mmol hydroxymethylfurfural/mol haemoglobin), was lower in cord than maternal blood (mean 18.7±1.7 versus 26.5±2.1, mean ± SD, p〈0.001). Glycosylated haemoglobin was higher following diabetic pregnancies, both in cord (diabetic 19.9± 1.6 versus normal 17.9±1.4, p〈0.001) and maternal samples (diabetic 27.7±1.5 versus normal 25.6±2.1, p〈0.005). Cord and maternal glycosylated haemoglobin correlated in the normal (r=0.60, p〈0.01) but not in the diabetic group (r=0.02, NS). Birth weight ratio was higher in infants of diabetic than of normal mothers (1.10±0.16 versus 0.99±0.13, p〈 0.05) but failed to correlate with cord or maternal glycosylated haemoglobin or, in the diabetic group, with mean blood glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284455
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Omeprazole in elderly duodenal ulcer patients: relationship between reduction in gastric acid secretion and fasting plasma gastrin (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 557-560 
    Details
    ISSN: 1432-1041
    Keywords: Omeprazole ; duodenal ulcer patients ; acid secretion ; plasma gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of omeprazole on acid secretion and gastrin levels has been investigated in 10 elderly duodenal ulcer patients in remission. Doses of 5, 10, 20 and 40 mg omeprazole were given once daily for 7 consecutive days and the basal (BAO) and peak (PAO) acid output and fasting plasma gastrin concentration were measured 24 h after the seventh dose. Omeprazole suppressed PAO significantly and dose-dependently after doses of 10, 20 and 40 mg, the suppression being 42%, 75% and 85%, respectively. No patient showed complete inhibition of PAO and at least 20 mg had to be given to obtain a marked inhibitory effect in all patients. Increasing the dose to 40 mg had only a slight additional effect compared to 20 mg. There was a relationship between degree of acid inhibition and the increase in fasting plasma gastrin. PAO had to be suppressed by more than 80% before a moderate increase in fasting plasma gastrin was observed. The optimal once-daily oral dose of omeprazole for inhibition of acid secretion in elderly patients appears to be 20 mg. Omeprazole 20–40 mg may cause a moderate increase in fasting plasma gastrin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279969
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Biliary secretion of felodipine metabolites in man after intravenous [14C]felodipine (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 421-424 
    Details
    ISSN: 1432-1041
    Keywords: felodipine ; bile ; dihydropyridines ; biliary secretion ; healthy volunteers ; drug metabolism ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The biliary secretion of [14C]felodipine in 4 healthy human subjects was studied by use of the multiple marker dilution principle with double lumen tubes placed in the stomach and intestine. Insignificant amounts of14C activity were recovered from gastric aspirates. The individual recovery from intestinal aspirates varied from 2.9 to 8.5% of the dose of radioactivity over the period of 4.5 h after dosing. Less than 0.1% was identified as unchanged felodipine. The results show that biliary secretion is a minor route of elimination of felodipine or its metabolites. Bile collection for 4.5 h had no significant effect on the pharmacokinetics of felodipine, although the 72 h urinary recovery of radioactivity tended to be lower when bile was collected (59%) than in the control experiment (66%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336677
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    Paper (German National Licenses)
    Fulltext
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