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  • 1
    Electronic Resource
    Electronic Resource
    Aging: Decline of dopamine-stimulated adenylate cyclase activity inMytilus edulis (Bivalvia) (1982)
    Springer
    Cellular and molecular neurobiology 2 (1982), S. 249-253 
    Details
    ISSN: 1573-6830
    Keywords: aging ; dopamine-stimulated cyclase ; dopamine ; chlorpromazine ; guanyl 5′-yl-imidodiphosphate [Gpp(NH)p] ; invertebrate organism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Aging is a multivariate process which results from a progressive accumulation alterations including, for example, biochemical and physiological changes, in an organism with time. These alterations occur in short- and long-lived organisms, in invertebrates and vertebrates. 2. The present study demonstrates that the maximum responsiveness and sensitivity of dopamine-stimulated adenylate cyclase diminish with age as determinedin vitro in pedal ganglion homogenates. The dopamine-blocking efficacy of chlorpromazine also decreased with age in 4-year-old organisms compared to 1- and 2-year-old organisms. However, adenylate cyclase activity does not diminish with age in response to the GTP stable analogue, Gpp(NH)p. 3. The results suggest that one aspect of aging inMytilus edulis specifically affects dopamine interaction with this receptor-mediated system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711152
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative aspects of opioid-dopamine interaction (1982)
    Springer
    Cellular and molecular neurobiology 2 (1982), S. 167-178 
    Details
    ISSN: 1573-6830
    Keywords: dopamine ; opioids ; invertebrate opioid responsiveness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Opiate receptors are found in invertebrate as well as mammalian systems, often in proximity to dopamergic systems. This review summarizes the interrelationships between these two transmitter systems in invertebrates. 2. The comparative data discussed here are of considerable significance. They recall that the opioid-dopamine relationships first demonstrated in the mammalian nervous system also apply to invertebrates and are therefore of more general importance. The results obtained in the molluskMytilus strengthen the concept that the activity of dopaminergic neurons may be modulated by afferent opioid signals and that, even in “more primitive” animals, interneuronal transfer of information is more complex than formerly visualized. Furthermore, the data indicate that endogenous opioids may exert tonic control over dopamine metabolism, thus implying interdependence of the two systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711145
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An opioid mechanism modulates central and not peripheral dopaminergic control of ciliary activity in the marine musselMytilus edulis (1986)
    Springer
    Cellular and molecular neurobiology 6 (1986), S. 17-30 
    Details
    ISSN: 1573-6830
    Keywords: opioid mechanisms ; ciliary activity ; morphine ; dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Opioid receptors and enkephalinergic neurons in the central nervous system ofMytilus edulis have been reported. Also known is that the lateral epithelium of the gill is innervated by serotonergic, cilioexcitatory neurons and dopaminergic, cilioinhibitory neurons. The aim of the present report is to look for an effect of opioid agonists on the nervous control of the lateral cilia. 2. Dopamine applied to the cerebral ganglion inhibited the activity of lateral cilia in the gill. This effect was blocked by the application of several opioids to the visceral ganglion. The block was reversed by the application of naloxone to the visceral ganglion. 3. Dopamine applied to the visceral ganglion also inhibited lateral ciliary activity as shown earlier. Opioids applied to the visceral ganglion partially blocked this effect but this was overcome by higher concentrations of dopamine. 4. Preparations with low endogenous rates of ciliary beating were stimulated by the application of opioids to the visceral ganglion. Naloxone blocked this effect. 5. Preparations with high endogenous rates of ciliary beating were inhibited by the application of naloxone to the visceral ganglion. 7. Electrical stimulation of the cerebrovisceral connective produced excitatory and inhibitory effects depending on the rate of stimulation. Morphine applied to the visceral ganglion diminished the cilioinhibitory effects and enhanced the cilioexcitatory effects of electrical stimulation. 8. Morphine applied to the gill had no effect on the cilioinhibitory action of dopamine applied to the visceral ganglion. There was no observable effect of opioids applied to the gill and no alteration in the cilioinhibitory effect of dopamine or the cilioexcitatory effect of serotonin applied directly to the gill in the presence of opioids. 9. Specific opioid binding sites were found in the visceral ganglion but were not found in gill, palp, mantle, or visceral mass tissue. 10. A dopamine-stimulated adenylate cyclase activity was again found in the visceral ganglion and the gill. Etorphine reduced the dopamine stimulation of cyclase in the ganglion but not in the gill. 11. It is postulated that a cilioinhibitory, dopaminergic mechanism includes nerves running from the cerebral ganglion to the gill with synaptic transmission in the visceral ganglion that can be modulated by opioids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00742972
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  • 4
    Electronic Resource
    Electronic Resource
    Aging alterations in the modulation of central dopaminergic cilioinhibition by etorphine in the marine mussel,Mytilus edulis: Decrease in the inhibition of presynaptic dopamine release (1987)
    Springer
    Cellular and molecular neurobiology 7 (1987), S. 209-219 
    Details
    ISSN: 1573-6830
    Keywords: aging ; dopamine ; etorphine ; presynaptic ; Mytilus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. This report further demonstrates that etorphine influences presynaptic dopamine release, which in turn centrally modulates peripheral cilioinhibition. 2. In older animals cilioinhibition has become enhanced due to a lack of responsiveness to endogenous opioids which results in greater dopamine release, causing a higher level of cilioinhibition as demonstrated by challenging the visceral ganglia with etorphine or destroying the dopaminergic component with 6-hydroxydopamine. 3. Only the central cilioinhibitory, not the peripheral inhibitory response, mechanism appears to be altered in older animals. Thus, the alteration appears in the central integrative mechanisms involved with regulating ciliary activity. 4. The KCl-stimulated release of dopamine is unaltered in both young and old organisms, whereas the opiate inhibition of the KCl-stimulated release of dopamine is reduced in older organisms. Thus, the aging-associated alteration is associated with a specific process. 5. The reduction of opioid influence and the resulting enhanced cilioinhibitory activity may make the organisms more susceptible to environmental stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711555
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    Paper (German National Licenses)
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