ISSN:
1573-6776
Keywords:
curdlan
;
gel
;
hydroxyethylation
;
protein drug delivery
;
urea
Source:
Springer Online Journal Archives 1860-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract The use of curdlan, a natural β-1,3-glucan, in protein drug delivery vehicles was studied by carrying out in vitro release studies with curdlan gels containing bovine serum albumin (BSA) as a model protein. Addition of urea (8 M) decreased the gel formation temperature to 37 °C. Curdlan was hydroxyethylated in order to form gels under mild conditions such as physiological temperature and pH. In gels formed in 8 M urea solution, urea was almost released after 2 h while BSA was completely released after 45–100 h. The total time for complete release of BSA increased with curdlan concentration within gels. The strength of hydroxyethylated curdlan gels (385.7 dyne cm−2) was weaker than that of curdlan gels formed in 8 M urea solution (6277 dyne cm−2).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005636205036
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