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  • 1
    Electronic Resource
    Electronic Resource
    Curdlan gels as protein drug delivery vehicles (2000)
    Springer
    Biotechnology letters 22 (2000), S. 1127-1130 
    Details
    ISSN: 1573-6776
    Keywords: curdlan ; gel ; hydroxyethylation ; protein drug delivery ; urea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The use of curdlan, a natural β-1,3-glucan, in protein drug delivery vehicles was studied by carrying out in vitro release studies with curdlan gels containing bovine serum albumin (BSA) as a model protein. Addition of urea (8 M) decreased the gel formation temperature to 37 °C. Curdlan was hydroxyethylated in order to form gels under mild conditions such as physiological temperature and pH. In gels formed in 8 M urea solution, urea was almost released after 2 h while BSA was completely released after 45–100 h. The total time for complete release of BSA increased with curdlan concentration within gels. The strength of hydroxyethylated curdlan gels (385.7 dyne cm−2) was weaker than that of curdlan gels formed in 8 M urea solution (6277 dyne cm−2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005636205036
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental optimization of fed-batch culture for poly-β-hydroxybutyric acid production (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 56 (1997), S. 697-705 
    Details
    ISSN: 0006-3592
    Keywords: poly-β-hydroxybutyric acid ; Alcaligenes eutrophus ; fed-batch culture ; high cell density culture ; optimization ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The optimal feed rate profiles of glucose and ammonium hydroxide were calculated using a proposed model, and implemented for the production of poly-β-hydroxybutyric acid (PHB) by Alcaligenes eutrophus. By implementing these optimal feed rates with a high glucose feed concentration of 700 g/L and an ammonium hydroxide concentration of 7%(w/w), it was possible to achieve a high final cell concentration of 141 g/L and a high PHB concentration of 105 g/L in 40 h of fed-batch operation. The PHB productivity was as high as 2.63 g/(L hr). © 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 56: 697-705, 1997.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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