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  • 1
    Electronic Resource
    Electronic Resource
    Effect of metergoline, a powerful and long-acting antiserotoninergic agent, on insulin secretion in normal subjects and in patients with chemical diabetes (1975)
    Springer
    Diabetologia 11 (1975), S. 165-167 
    Details
    ISSN: 1432-0428
    Keywords: Serotonin ; 5-hydroxytryptamine ; metergoline ; arginine ; antiserotoninergic drugs ; insulin secretion ; glucose tolerance test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of metergoline on insulin secretion has been evaluated in normal subjects and in patients with chemical diabetes. The repeated administration of metergoline, 2 mg at four-hour intervals to give a total of 24 mg, has enhanced insulin secretion in response to i. v. glucose in normal subjects but not in chemical diabetics. No changes in blood glucose pattern were observed. Under similar conditions, metergoline administration caused a slight but significant decrease in arginine-induced insulin release, both in normal subjects and in chemical diabetics. These results support the concept of a serotoninergic control of insulin secretion and suggest that serotonin exerts different effects on insulin release according to the different stimuli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429842
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metergoline versus bromocriptine in the prevention of puerperal lactation (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 181-183 
    Details
    ISSN: 1432-1041
    Keywords: metergoline ; prolactin ; bromocriptine ; ergot alkaloids ; puerperal lactation ; anti-prolactin drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double blind study of the prevention of puerperal lactation, the clinical efficacy of two antiprolactin drugs was compared: metergoline 4 mg tid and bromocriptine 2.5 mg bid were both given for 7 days. An additional 7 days of treatment was administered to 16 patients in whom mammary activity was still present or appeared in the following 3 days. The first 7 day period of treatment was effective in 16/20 women receiving metergoline and in 7/20 on bromocriptine (p〈0.02); the second period of treatment was effective in all remaining patients. These data indicate that metergoline acts rapidly to arrest puerperal lactation, possibly by a mechanism different from that of bromocriptine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542465
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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