ISSN:
1573-7217
Keywords:
alkykphosphocholines
;
breast carcinoma
;
eicosanylphosphocholine
;
hexadecylphosphocholine
;
liposomes
;
nude mice
;
octadecylphosphocholine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary This study examines thein vitro andin vivo activity of alkylphosphocholines (APC) in experimental human breast carcinomas. Three analogs, hexadecylphosphocholine (HPC), octadecylphosphocholine (OPC) and eicosanylphosphocholine (EPC) were investigated. Three hormone receptor negative cell lines were sensitive to all three APCsin vitro whereas the receptor positive MCF-7 line was more resistant. Sensitivity was seen in 4/6 hormone receptor negative tumorsin vivo, with HPC being the most active analog. There were no antitumor effects in the four receptor positive models. The reasons for these differences in response between hormone receptor negative and -positive lines are not yet understood and require further study. Gastrointestinal toxicity and hemolysis, the major side effects of the APCs, were reduced by the use of liposomal preparations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00666004
Permalink