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  • 1
    Electronic Resource
    Electronic Resource
    Fixierung der basophilen Granulozyten des Menschen mit 5-Aminoacridin-hydrochlorid (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 185-186 
    Details
    ISSN: 1432-1440
    Keywords: Basophil fixation, human blood basophils, 5-aminoacridine hydrochloride ; Basophilenfixierung ; menschliche Blutbasophile ; 5-Aminoacridin-hydrochlorid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 5-Aminoacridin-hydrochlorid (0.4g gelöst in 50%igem Äthanol) erwies sich nach einer Vorfixierung mit Methanol-Formol (9:1 V/V) als ein hervorragendes Fixativum für die Erhaltung der wasserlöslichen Granula der menschlichen Blutbasophilen. Die Granula waren in allen Präparaten gut erhalten und wiesen keine Zeichen einer Diffusion auf. Im Gegensatz zu den anderen spezifischen Fixativa erzeugt 5-Aminoacridin-hydrochlorid in Kernspurenemulsionen keine chemographischen Effekte. Die Substanz eignet sich damit besonders für die autoradiographische Untersuchung von Blutbasophilen des Menschen.
    Notes: Summary 5-aminoacridine hydrochloride (0.4% in 50% aqueous ethanol) proved to be a useful fixative for the preservation of human blood basophils pretreated with methanol-formaldehyde (9:1 V/V). Leaching of the water soluble basophil granules or other artificial cell alterations common to fixatives in current use were not observed. The organic compound used did not induce any chemographic artifacts in nuclear tracers, in contrast to most of the other fixatives hitherto applied. 5-aminoacridine hydrochloride is therefore particularly suitable for autoradiography of the human blood basophils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01466764
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  • 2
    Electronic Resource
    Electronic Resource
    The synthesis of p-nitrophenyl 5-O-α-L-arabino-furanosyl-α-L-arabinofuranoside
    Amsterdam : Elsevier
    Carbohydrate Research 48 (1976), S. 128-131 
    Details
    ISSN: 0008-6215
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0008-6215(00)83520-X
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of sterically stabilized hexadecylphosphocholine liposomes versus conventional liposomes and free hexadecylphosphocholine in tumor-free and human breast carcinoma bearing mice (1999)
    Springer
    Breast cancer research and treatment 58 (1999), S. 71-80 
    Details
    ISSN: 1573-7217
    Keywords: hexadecylphosphocholine ; human breast carcinoma ; pharmacokinetics ; sterically stabilized liposomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetics of free and different liposomal formulations of hexadecylphosphocholine (HPC) was investigated in tumor-bearing (human mammary tumor MaTu) and tumor-free mice after intravenous and intraperitoneal administration. The levels of HPC were evaluated at different times in serum, normal tissues, and tumor. The purpose was to test the hypothesis that the enhanced therapeutic efficacy of sterically stabilized HPC liposomes in comparison to conventional vesicles and free HPC is due to its pharmacokinetics. Conventional non-compartmental pharmacokinetic analysis and an elaborate three- and four-compartmental model were used for explaining the experimental data. The serum levels of HPC obtained with sterically stabilized liposomes were only consistently higher in comparison to conventional vesicles and free HPC in the first 4 h. In the xenografted MaTu carcinoma, the differences of the HPC content between the different groups are unexpectedly low and do not reflect the high therapeutic activity [5] of sterically stabilized HPC liposomes. Detailed analysis shows that the liposomally encapsulated drug displays a modified pharmacokinetic behavior, which may also involve lymphatic absorption of the liposomal drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006224611505
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  • 4
    Electronic Resource
    Electronic Resource
    Antineoplastic activity of sterically stabilized alkylphosphocholine liposomes in human breast carcinomas (1997)
    Springer
    Breast cancer research and treatment 43 (1997), S. 237-246 
    Details
    ISSN: 1573-7217
    Keywords: alkylphosphocholine ; hexadecylphosphocholine ; human breast carcinoma ; sterically stabilized liposomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract New sterically stabilized liposomes derived from the antitumoragent hexadecylphosphocholine with reduced uptake by the mononuclearphagocyte system and improved antitumor activities were developedand tested. The bilayer of such sterically stabilizedliposomes consists of hexadecylphosphocholine, cholesterol and polyethylene glycol-linkedphosphoethanolamine. The measurement of carbon clearance in miceshows that these stabilized liposomes, in contrast toconventional alkylphosphocholine liposomes, are not largely engulfed bythe mononuclear phagocyte system. Their therapeutic activity onexperimental human breast carcinomas MaTu, MT-1 and MT-3was tested in nude mice. Especially in theMaTu models the sterically stabilized hexadecylphosphocholine liposomes resultedin significantly reduced tumor growth in comparison toconventional hexadecylphosphocholine liposomes or free hexadecylphosphocholine. The enhancedtherapeutic efficacy of sterically stabilized hexadecylphosphocholine liposomes isprobably related to the extended circulation time ofthe formulation and its accumulation in tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005798715192
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  • 5
    Electronic Resource
    Electronic Resource
    Automated percutaneous lumbar discectomy with and without chymopapain pretreatment versus non-automated, discoscopy-monitored percutaneous lumbar discectomy (1990)
    Springer
    Archives of orthopaedic and trauma surgery 109 (1990), S. 211-216 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Percutaneous lumbar discectomy has gained growing interest during recent years as an alternative to open surgery for protrusions and non-sequestrated subligamentous intervertebral disc herniations. As a less invasive method it competes with chemonucleolysis. At least two modifications are known to date: automated percutaneous lumbar discectomy (APLD) with a 2-mm suction probe and non-automated, discoscopy-monitored percutaneous lumbar discectomy with a suction rongeur and a motor-driven shaver (NAPLD). In this study these two methods are compared for the amount of material extracted, dependence upon the degree of degeneration of the disc and intrinsic technical problems, using 20 human cadaver lumbar specimens for experimental testing. Total nucleotomy was not possible with either method. APLD yielded significantly less material and proved to be less effective in severely degenerated intervertebral discs than the NAPLD procedure, as preexisting gaps within the degenerated nucleus pulposus allowed the tissue to shift away from the tip of the 2-mm probe and facilitated displacement of the probe within the anulus fibrosus. By contrast, the rongeur, which first cuts the material to be removed and then carries it away by suction, was much more effective. Further data to support the advantages of non-automated percutaneous nucleotomy are discussed. Pretreatment of the disc with chymopapain did not result in a higher yield of nucleus material when combined with APLD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00453143
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  • 6
    Electronic Resource
    Electronic Resource
    Autoradiographische Darstellung der basophilen Granulozyten des Menschen (1975)
    Springer
    Annals of hematology 30 (1975), S. 199-202 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A new technique is described which enables a selective tinctorial visualization of human blood basophils in autoradiographic preparations. Consecutive administration of 5-aminoacridine hydrochloride and aldehyde fuchsin rendered a sufficient preservation of basophils preventing leaching of their water soluble granules. Extensive control tests provided sufficient evidence to exclude chemographic artifacts produced by other histochemical procedures. The technique eliminates the obstacles to study the kinetics of human blood basophils and their relationship to atopic hypersensitivity reactions applying tritiated thymidine and radioiodine labeled lgE or corresponding antisera.
    Notes: Zusammenfassung Es wird eine neue Technik beschrieben, die eine selektive Darstellung der menschlichen Blutbasophilen in autoradiographischen Präparaten ermöglicht. Durch sukzessive Anwendung von 5-Aminoacridin-Hydrochlorid und Aldehyd-Fuchsin werden die wasserlöslichen Strukturen der menschlichen Blutbasophilen für den autoradiographischen Prozeß stabilisiert, ohne daß dabei chemographische Artefakte auftreten. Die Methode erlaubt es, die Kinetik der Blutbasophilen mit markierten Kernbasen sowie ihre Rolle im Rahmen atopischer Reaktionen durch Anwendung von radiojodmarkiertem Immunglobulin E oder von entsprechendem Antiserum zu studieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01633954
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  • 7
    Electronic Resource
    Electronic Resource
    Antineoplastic activity of alkylphosphocholines (APC) in human breast carcinomasin vivo andin vitro; use of liposomes (1994)
    Springer
    Breast cancer research and treatment 32 (1994), S. 269-279 
    Details
    ISSN: 1573-7217
    Keywords: alkykphosphocholines ; breast carcinoma ; eicosanylphosphocholine ; hexadecylphosphocholine ; liposomes ; nude mice ; octadecylphosphocholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study examines thein vitro andin vivo activity of alkylphosphocholines (APC) in experimental human breast carcinomas. Three analogs, hexadecylphosphocholine (HPC), octadecylphosphocholine (OPC) and eicosanylphosphocholine (EPC) were investigated. Three hormone receptor negative cell lines were sensitive to all three APCsin vitro whereas the receptor positive MCF-7 line was more resistant. Sensitivity was seen in 4/6 hormone receptor negative tumorsin vivo, with HPC being the most active analog. There were no antitumor effects in the four receptor positive models. The reasons for these differences in response between hormone receptor negative and -positive lines are not yet understood and require further study. Gastrointestinal toxicity and hemolysis, the major side effects of the APCs, were reduced by the use of liposomal preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00666004
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  • 8
    Electronic Resource
    Electronic Resource
    Melting of Monolayers of Some Halomethanes and Haloethanes Physisorbed on Graphite (1998)
    Springer
    Journal of low temperature physics 111 (1998), S. 339-348 
    Details
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The melting of monolayers of nine halomethanes and haloethanes physisorbed on exfoliated graphite is discussed on the basis of heat capacity and X-ray diffraction results. It is shown that the melting transition of incommensurate, triangular, orientationally disordered phase is continuous, whereas other two–dimensional solid phases melt discontinuously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022231602436
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  • 9
    Electronic Resource
    Electronic Resource
    An autoradiographic study of human blood basophils (1975)
    Springer
    Journal of molecular histology 7 (1975), S. 357-360 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Synopsis The aim of this paper is the selective visualization of human blood basophils in autoradiographs. [3H]Thymidine-labelled basophils in buffy coat smears were fixed in methanol-formaldehyde followed by 5-aminoacridine hydrochloride and stained with basic Aldehyde Fuchsin prior to autoradiographic processing. The technique described represents a simple method for quantitative autoradiographic studies on basophil kinetics and the interaction of these cells with IgE-mediated atopias.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01007020
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  • 10
    Electronic Resource
    Electronic Resource
    α-L-Arabinofuranoside, β-D-Xylopyranoside und β-Cellobioside von cytotoxischen Phenolen (1975)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 317 (1975), S. 752-756 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Reaktion von Tetra-O-acetyl-L-arabinose bzw. 1, 2, 3, 4-Tetra-O-acetyl-β-D-xylose sowie Octa-O-acetyl-β-cellobiose mit 4-[N, N-Bis-(2-chloräthyl)-amino]-phenol · HCl entsprechend dem HELFERICH-Verfahren und anschließende ZEMPLÉN-Entacetylierung werden die Glykoside 1f, 2b und 3 b erhalten, in denen die alkylierende Aktivität der N-Lost-Gruppierung herabgesetzt ist. Über die pH-abhängige Spaltung dieser Glykoside und ein daraus resultierendes Therapie-Konzept wird kurz berichtet.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19753170507
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