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  • 1
    Electronic Resource
    Electronic Resource
    Angiographic Follow-up of One-Stage Radiosurgery for Multiple Cerebral Arteriovenous Malformations (1998)
    Springer
    Journal of radiosurgery 1 (1998), S. 213-221 
    Details
    ISSN: 1573-8752
    Keywords: Arteriovenous malformation ; multiple AVMs ; radiosurgery ; γ knife
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Because multiple cerebral arteriovenous malformations (AVMs) are extremely rare, little information is available as to stereotactic radiosurgery for multiple AVMs. We present a patient with three cerebral AVMs who underwent one stage gamma knife radiosurgery for all three nidi. Each nidus was covered with a 90% isodose volume and a central dose of 27.8 Gy was used to obtain a marginal dose of 25 Gy. Angiography that was performed 10 months after irradiation demonstrated complete obliteration in one nidus, remarkable shrinkage in another and no significant changes in the other. The patient has experienced neither bleeding nor complications related to irradiation, to date. We consider one of the major benefits of stereotactic radiosurgery to be that multiple intracranial AVMs, if all nidi are sufficiently small (〈3 cm), can be treated with a single procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:JORA.0000015196.57676.6e
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinicopathologic evaluation of the trend toward histologically poor differentiation with submucosal invasion in superficial early colorectal adenocarcinomas (2000)
    Springer
    Journal of gastroenterology 35 (2000), S. 832-839 
    Details
    ISSN: 1435-5922
    Keywords: Key words: early colorectal adenocarcinoma ; submucosal adenocarcinoma ; poorly differentiated ; well differentiated ; superficial type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: We examined differences in the degree of differentiation in intramucosal and submucosal areas of involvement in early colorectal adenocarcinomas of 131 patients and compared these findings with tumor morphology. In addition, K-ras and p53 protein expression was determined in cases where poorly differentiated adenocarcinoma was detected in the submucosa. We identified 6 patients with both intramucosal differentiated (well-to-moderately differentiated) adenocarcinoma and submucosal poorly differentiated adenocarcinoma (MwSp). The morphological tumor type was superficial in all MwSp cases. The observed MwSp adenocarcinomas had a significantly higher frequency of lymphatic invasion than the more common superficial type of adenocarcinoma. Genetic analysis of these MwSp lesions was carried out using the polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) method to detect the presence of K-ras codon 12 point mutations, and an immunologic staining technique was used to identify the presence of p53 protein overexpression. The K-ras mutation rate was 33.3%, and the p53 overexpression rate was 66.7% for the MwSp adenocarcinomas. Our findings suggest that the rapidly reduced histologic differentiation observed in some of these superficial colorectal adenocarcinomas may play a role in their higher degree of invasiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350070020
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    Paper (German National Licenses)
    Fulltext
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