ISSN:
0899-0042
Schlagwort(e):
preferential enrichment
;
enantiomeric enrichment
;
mixed crystal
;
solid solution
;
racemic compound crystals
;
X-ray crystallography
;
chiral ammonium sulfonate
;
reversal of chirality
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
The X-ray crystal structure of (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylammonium p-nitrobenzenesulfonate [(±)-NNMe2], which shows the novel enantiomeric resolution phenomenon Preferential Enrichment, has been compared with that of (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy) phenylcarbamoyl]ethyl]dimethylammonium p-toluenesulfonate [(±)-NTMe2], which does not show the phenomenon. The stable crystalline form of (±)-NNMe2 is a racemic compound, while that of (±)-NTMe2 is a mixed (disordered) crystal composed of the two enantiomers. The intermolecular hydrogen bonding mode in the crystal of (±)-NNMe2 was very different from that of (±)-NTMe2. Chirality 10:705-710, 1998. © 1998 Wiley-Liss, Inc.
Zusätzliches Material:
6 Ill.
Materialart:
Digitale Medien
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