ISSN:
0899-0042
Keywords:
preferential enrichment
;
enantiomeric enrichment
;
mixed crystal
;
solid solution
;
racemic compound crystals
;
X-ray crystallography
;
chiral ammonium sulfonate
;
reversal of chirality
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The X-ray crystal structure of (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl]dimethylammonium p-nitrobenzenesulfonate [(±)-NNMe2], which shows the novel enantiomeric resolution phenomenon Preferential Enrichment, has been compared with that of (±)-[2-[4-(3-ethoxy-2-hydroxypropoxy) phenylcarbamoyl]ethyl]dimethylammonium p-toluenesulfonate [(±)-NTMe2], which does not show the phenomenon. The stable crystalline form of (±)-NNMe2 is a racemic compound, while that of (±)-NTMe2 is a mixed (disordered) crystal composed of the two enantiomers. The intermolecular hydrogen bonding mode in the crystal of (±)-NNMe2 was very different from that of (±)-NTMe2. Chirality 10:705-710, 1998. © 1998 Wiley-Liss, Inc.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
