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  • 11
    Electronic Resource
    Electronic Resource
    Ultrastructure of the endolymphatic sac in the mongolian gerbil (1987)
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1987), S. 284-287 
    Details
    ISSN: 1434-4726
    Keywords: Mongolian gerbil ; Endolymphatic sac ; Transmission electron microscopy ; Elastic fibers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe our findings in an ultrastructural study of the endolymphatic sac of the mongolian gerbil. In conjunction with its specific renal physiology, enabling this animal to withstand longterm water deprivation, we have used our findings to hypothesize the existence of a local monitoring system within the endolymphatic space. The presence of elastic tissue in the subepithelial space of the endolymphatic sac could explain the mechanism through which this structure equilibrates endolymphatic pressure changes. Finally, we propose that a secretion of water-retaining macromolecules may act through osmotic forces to modulate inner ear fluid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00468637
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    An experimental study of vancomycin-induced cochlear damage (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 67-70 
    Details
    ISSN: 1434-4726
    Keywords: Ototoxicity ; Vancomycin ; Mongolian gerbil ; Evoked response audiometry ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vancomycin has been successfully used clinically for many years. Although early reports found ototoxicity to be a side effect of this antibiotic, later studies could not confirm this. For this reason we have started an experimental study in an animal model on the ototoxic effects of vancomycin. We now report the results of this study. Fourteen healthy Mongolian gerbils were treated with intraperitoneal injections of vancomycin (80 mg/kg per day) for a 2-week period. Before and after treatment each animal's hearing was evaluated by evoked response audiometry. Post mortem the cochleae were investigated by scanning electron microscopy in Amsterdam and by microdissection with surface preparations (hair cell counting) in Stockholm. The results of this study show that there is no clear evidence for the existence of ototoxicity due to vancomycin in this dosage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00457456
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    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Lectin detection of carbohydrates in the endolymphatic sac (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 89-93 
    Details
    ISSN: 1434-4726
    Keywords: Endolymphatic sac ; Carbohydrate ; Lectin ; Fluid transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The carbohydrate contents of the guinea pig endolymphatic sac were investigated by the use of lectins. The lumen of the endolymphatic sac was filled with stainable precipitate containing N-acetyl glucosamine, mannose, glucose, galactose and fucose. N-Acetyl galactosamine was also detected but in minute amounts. This composition corresponded to other areas in the inner ear, such as the cupula, the otolithic membrane and the tectorial membrane. The function of these carbohydrates may play an important role in preventing the lumen of the endolymphatic sac from collapsing as well as in regulating transepithelial fluid transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00457460
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    Paper (German National Licenses)
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  • 14
    Electronic Resource
    Electronic Resource
    Expression of epidermal growth factor, epidermal growth factor receptor and transforming growth factor-alpha in the human fetal inner ear (1996)
    Springer
    European archives of oto-rhino-laryngology and head & neck 253 (1996), S. 494-497 
    Details
    ISSN: 1434-4726
    Keywords: Epidermal growth factor ; Epidermal growth factor receptor ; Transforming growth factor-alpha Human fetal inner ear ; Development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of epidermal growth factor (EGF), EGF receptor and transforming growth factor (TGF)-alpha was analyzed in the human fetal inner ear using immuno-histochemical methods. EGF receptor was observed only in 9.5-week-old fetal vestibular epithelia. In 14- and 16-week-old fetuses, EGF receptor could not be detected. TGF-alpha was observed strongly in the 9- and 11-week-old vestibular epithelia, whereas only trace amounts were detectable in the 14- and 16-week-old vestibular epithelia. These findings suggest that EGF and TGF-alpha probably have a mitogenic effect in the sensory epithelia of the fetal inner ear, especially at early stages of development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179956
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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