Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Relationship between diastolic hypertension and myocardial morphology and function in elderly males with diabetes mellitus (1996)
    Springer
    Diabetologia 39 (1996), S. 1603-1606 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Non-insulin diabetes mellitus ; hypertension ; M-mode echocardiography ; heart function.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The existence of a distinct diabetic cardiomyopathy, characterized by a raised left ventricular mass, has previously been suggested. However, as diabetes mellitus is associated with both left ventricular hypertrophy and hypertension a confounding effect of raised blood pressure in diabetic patients has to be considered. In the present cross-sectional study an echocardiographical examination was performed as part of a health screening survey in 582 males, aged 70 years. After the exclusion of subjects with coronary heart disease or those on regular antihypertensive treatment, 30 normotensive subjects with diabetes were compared with 10 subjects with non-insulin-dependent diabetes (NIDDM) and a diastolic blood pressure 90 mm Hg or more and 203 normotensive control subjects with normal glucose tolerance. Both groups with NIDDM showed a significantly increased left atrial diameter (4.4 ± 0.7 vs 4.0 ± 0.5 cm, p 〈 0.05) and an increased atrial component in diastole (A-wave, p 〈 0.01) compared to the control subjects. Left ventricular mass was, however, only marginally and not significantly elevated in the diabetic subjects when compared to the healthy control subjects (133 ± 19 and 133 ± 28 vs 128 ± 25 g/m2). Only in the subjects with concomitant diabetes and a raised blood pressure was the intraventricular septum significantly enlarged (p 〈 0.05). Thus, in the present sample no distinct diabetic cardiomyopathy with an increased left ventricular mass, independent of the influence of hypertension could be detected. The myocardial alterations in these diabetic males were restricted to an increased left atrial size and an impaired diastolic function. [Diabetologia (1996) 39: 1603–1606]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050621
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    The activity of β-hydroxyacyl-CoA dehydrogenase in the pancreatic islets of hyperglycaemic mice (1970)
    Springer
    Diabetologia 6 (1970), S. 526-528 
    Details
    ISSN: 1432-0428
    Keywords: Hyperglycaemic syndrome of mice (NZO, obob) ; β-oxidation of fatty acids ; β-hydroxyacyl-CoA dehydrogenase ; islets of Langerhans ; liver, heart and skeletal muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'activité de laβ-hydroxyacyl-CoA déshydrogénase (EC 1.1.1.35.) a été mesurée, selon les principes de microtechniques de Lowry, dans les îlots et les acini pancréatiques, le foie, le muscle cardiaque et le muscle du squelette chez des souris de la souche obése de NouvelleZélande (NZO) et de la souche obése hyperglycémique (obob). L'enzyme dosé montrait la même dépendance du pH dans les îlots, le foie et le muscle cardiaque. L'activité enzymatique la plus élevée a été trouvée dans les îlots pancréatiques et le muscle cardiaque, et représentait 2 à 5 fois l'activité obtenue dans les acini pancréatiques, le foie et le muscle du squelette. Les résultats montrent qu'une condition nécessaire pour uneβ-oxydation rapide des acides gras existe dans les îlots de Langerhans.
    Abstract: Zusammenfassung Die Aktivität derβ-Hydroxyacyl-CoA Dehydrogenase (EC 1.1.1.35.) wurde nach den Prinzipien der Lowry-Mikrotechniken in den Pankreasinseln und -Acini, der Leber, dem Herzen und dem Skeletmuskel von Mäusen des fettsüchtigen New Zealand-Stammes (NZO) und in dem fettsüchtig-hyperglykämischen Stamm (obob) gemessen. Das untersuchte Enzym zeigte die gleiche pH-Abhängigkeit in Material aus den Inseln der Leber und dem Herzmuskel. Die höchste Enzymaktivität fand sich in Pankreasinseln und Herzmuskel; sie war zwei bis fünfmal höher als in den Pankreas-Azini, der Leber und der Skeletmuskulatur. Die Ergebnisse zeigen, daß eine Voraussetzung für eine schnelleβ-Oxydation von Fettsäuren in den Langerhans'schen Inseln erfüllt ist.
    Notes: Summary The activity ofβ-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35.) was measured according to the principles of the Lowry microtechniques in pancreatic islets and acini, liver, heart and skeletal muscle in mice of the New Zealand obese strain (NZO) and the obese hyperglycaemic strain (obob). The assayed enzyme showed the same pH dependence in material from islets, liver and heart muscle. The highest enzymatic activity was found in pancreatic islets and heart muscle, and this was 2 to 5 times the activity obtained in pancreatic acini, liver and skeletal muscle. The results show that one prerequisite for a fastβ-oxidation of fatty acids exists in the islets of Langerhans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211896
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Limited benefit of treatment of diabetic polyneuropathy with an aldose reductase inhibitor: a 24-week controlled trial (1985)
    Springer
    Diabetologia 28 (1985), S. 323-329 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; polyneuropathy ; sorbitol accumulation ; aldose reductase inhibitor ; clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of the aldose reductase inhibitor, sorbinil, on symptomatic symmetrical diabetic polyneuropathy were studied during a 6-month period in a double-blind parallel group placebo-controlled trial. Twenty-seven patients received sorbinil and 28 placebo. The patients were assessed by clinical examination, neurophysiological measurements, sensory threshold determinations and tests of autonomic nerve function. No major clinical benefit was seen in the sorbiniltreated patients and no differences in sensory thresholds were observed. In three out of nine neurophysiological tests (motor nerve conduction velocity of the posterior tibial nerve, F-wave latency and sensory distal latency of the ulnar nerve) and one out of five tests of autonomic nerve function (heart rate variation during deep breathing) significant differences between the patient groups evolved in favour of sorbinil treatment. An overall evaluation of the temporal development of these and remaining neurophysiological and autonomic variables suggested a small but significant benefit from sorbinil treatment. There was no evidence of continuing improvement throughout the treatment period and beneficial effects observed were no greater than those seen in previous trials of considerably shorter treatment periods. It is concluded that sorbinil treatment results in some improvement in peripheral nerve function in symptomatic diabetic polyneuropathy, but that the long-term effect may be of limited value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283137
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    MUREX: a land-surface field experiment to study the annual cycle of the energy and water budgets (1999)
    Springer
    Annales geophysicae 17 (1999), S. 838-854 
    Details
    ISSN: 0992-7689
    Keywords: Hydrology (evapotranspiration; soil moisture; water-energy interactions)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The MUREX (monitoring the usable soil reservoir experimentally) experiment was designed to provide continuous time series of field data over a long period, in order to improve and validate the Soil-vegetation-Atmosphere Transfer (SVAT) parameterisations employed in meteorological models. Intensive measurements were performed for more than three years over fallow farmland in southwestern France. To capture the main processes controlling land-atmosphere exchanges, the local climate was fully characterised, and surface water and energy fluxes, vegetation biomass, soil moisture profiles, surface soil moisture and surface and soil temperature were monitored. Additional physiological measurements were carried out during selected periods to describe the biological control of the fluxes. The MUREX data of 1995, 1996, and 1997 are presented. Four SVAT models are applied to the annual cycle of 1995. In general, they succeed in simulating the main features of the fallow functioning, although some shortcomings are revealed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-999-0838-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    Accelerated gastric emptying during hypoglycaemia is not associated with changes in plasma motilin levels (1997)
    Springer
    Acta diabetologica 34 (1997), S. 194-198 
    Details
    ISSN: 1432-5233
    Keywords: Key words Hypoglycaemia ; Gastric emptying ; Atropine ; Motilin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined whether or not changes in plasma concentrations of motilin and other gastrointestinal hormones known to affect gastric motility are associated with the accelerated gastric emptying seen during hypoglyc-aemia. While studying gastric emptying by scintigraphy in eight healthy subjects, the plasma concentrations of glucagon, adrenaline, motilin, gastrin, neuropeptide Y and somatostatin were measured during normoglycaemia and hypoglycaemia with simultaneous infusion of either atropine or saline. Blood glucose concentrations were checked by an insulin-glucose clamp. The plasma levels of glucagon and adrenaline increased markedly during both hypoglycaemic examinations compared with normoglycaemia. Neither motilin nor any of the other hormones displayed considerable changes during hypoglycaemia with and without atropine compared with normoglycaemia. No further information about the mechanisms behind the accelerated gastric emptying rate during hypoglycaemia was obtained by analysing motilin and the other gastrointestinal hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920050073
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Impaired cutaneous reactive hyperaemia during hypoglycaemia in young insulin-dependent diabetic patients and healthy controls (1992)
    Springer
    Acta diabetologica 29 (1992), S. 25-28 
    Details
    ISSN: 1432-5233
    Keywords: Insulin-dependent diabetes mellitus ; Hypoglycaemia ; Skin blood flow ; Reactive hyperaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to compare the cutaneous postischaemic hyperaemic response in young insulin-dependent diabetic patients and healthy subjects during normoglycaemia, acute insulin-induced hypoglycaemia and in the posthypoglycaemic state. After a night of normoglycaemia the cutaneous postischaemic hyperaemic response in the forearm skin, measured by the transcutaneousPO 2 method, was the same in both groups. A reduction of the maximal postischaemic vasodilatory response was observed in diabetic patients from 2.4±0.3 to 2.0±0.2 kPa (P〈0.05) and in control subjects from 2.7±0.3 to 1.8±0.2 kPa (P〈0.02) during insulin-induced hypoglycaemia (plasma glucose〈2 mmol/l). Complete recovery of the vasodilatory response occurred in subjects in the posthypoglycaemic state. We conclude that hypoglycaemia induced a transient reduction of the vasodilatory response, which was rapidly reversed after glucose counter-regulation, in both diabetic patients and healthy controls. Thus, the prevailing blood glucose concentration must be taken into account when the postischaemic vasodilatory response is investigated in diabetic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572825
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    The effect of euglucaemic hyperinsulinaemia on forearm blood flow and glucose uptake in the human forearm (1998)
    Springer
    Acta diabetologica 35 (1998), S. 203-206 
    Details
    ISSN: 1432-5233
    Keywords: Key words Glucose ; Insulin ; Hyperinsulinaemia ; Blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Insulin-mediated stimulation of blood flow to skeletal muscle has been proposed to be of major importance for insulin-mediated glucose uptake. The aim of this study was to investigate the relative importance of blood flow and glucose extraction as determinants of insulin-mediated glucose uptake in the human forearm. Forearm blood flow (FBF), glucose extraction and oxygen consumption were evaluated for 100 min during the euglycaemic hyperinsulinaemic clamp (92 mU/l) in nine healthy subjects. FBF was measured by venous occlusion plethysmography. Forearm glucose uptake increased sevenfold during the hyperinsulinaemia (P〈0.001). Forearm glucose extraction showed a minor increase during the first 10 min of hyperinsulinaemia, but the most marked increase took place between 10 and 20 min (+170%). Thereafter, only a minor further increase was seen. During the first 10 min of hyperinsulinaemia FBF was unchanged. Thereafter, FBF increased steadily to a plateau reached after 60 min (+50%, P〈0.001). A close relationship between whole body glucose uptake and FBF was seen at the end of the clamp (r = 0.75, P〈0.02), but at this time the relationship between whole body glucose uptake and forearm glucose extraction was not significant. The modest increase in O2 consumption seen at the beginning of the clamp (+19%) was not related to FBF during the early phase of the clamp. In conclusion, the early course of insulin-mediated glucose uptake in the human forearm was mainly due to an increase in glucose extraction. However, with time the insulin-mediated increase in blood flow increased in importance and after 100 min of hyperinsulinaemia FBF was the major determinant of glucose uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920050132
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Glucose dependent alterations of mitochondrial ultrastructure and enzyme content in mouse pancreatic islets maintained in tissue culture (1975)
    Springer
    Cell & tissue research 162 (1975), S. 313-321 
    Details
    ISSN: 1432-0878
    Keywords: Islands of Langerhans ; Mitochondria ; Enzymes ; Tissue Culture ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Isolated islets of Langerhans from mice were maintained in tissue culture for one week at either a high (28 mM) or a low (3.3 mM) extracellular glucose concentration. Electron microscopic morphometry by means of stereological methods revealed a much greater volume of mitochondria in islet cells cultured at low glucose than in those cultured at high glucose. The former islets also showed a higher activity of the mitochondrial marker enzyme, L-3-hydroxyacyl-CoA-dehydrogenase (E.C.1.1.1.35). These results indicate a true mitochondrial hypertrophy at the low glucose concentration. Although it is known from previous studies that the islet cell metabolism is diminished after low-glucose culture, the present observations of an increased mitochondrial volume probably do not reflect a degenerative process, but rather adaptive changes towards oxidation of energy yielding substrates other than glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220177
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    Well-being and treatment satisfaction in adults with diabetes: A Swedish population-based study (1995)
    Springer
    Quality of life research 4 (1995), S. 515-522 
    Details
    ISSN: 1573-2649
    Keywords: Diabetes mellitus ; outcomes ; quality of life ; reliabllity ; sex factors ; validity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to implement the St Vincent Declaration programme, instruments for quality assurance of medical outcomes as well as measures of psychological outcomes of diabetes care had to be developed. This paper presents baseline values for three questionnaires measuring psychological Wellbeing, Treatment Statisfaction and General Health among a representative sample of adult people with diabetes in Sweden consisting of 423 individuals of which 153 were insulin treated and 270 were diet/tablet-treated. Cronbach's α indicated that each of the Well-being and Treatment Satisfaction subscales was internally reliable, alphas ranging from 0.66–0.88. Factor analysis resulted in identification of five subscales (depression, anxiety, positive well-being, treatment satisfaction and metabolic control). There was no relation between any of the quality of life subscales with HbA1c, BMI, duration of diabetes, frequency of blood glucose tests per day, insulin regimens or diabetic complications. Females reported a more negative impact of diabetes on daily life compared with males (p〈0.001). In conclusion, the Well-being and Treatment Satisfaction scales are reliable for quality assurance purposes in diabetes while the briefer general health instrument provides a useful assessment of the global impact of a chronic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634746
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...