Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Difference in earnings structures across local labor markets
    Amsterdam : Elsevier
    Economics Letters 37 (1991), S. 309-314 
    Details
    ISSN: 0165-1765
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1765(91)90228-D
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    The effect of occupational segregation on the relative earnings of black males
    Amsterdam : Elsevier
    Economics Letters 30 (1989), S. 77-83 
    Details
    ISSN: 0165-1765
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1765(89)90160-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Side effects of AZT prophylaxis after occupational exposure to HIV-infected blood (1994)
    Springer
    Annals of hematology 69 (1994), S. 135-138 
    Details
    ISSN: 1432-0584
    Keywords: AZT prophylaxis ; Side effects Occupational exposure ; Neutropenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It was the objective of this study to document and evaluate AZT-induced short-term toxicity in healthy individuals. The study was designed as a longitudinal monocentric side-effect monitoring study with prospective data collection. It was carried out at the Cologne University Hospital. The study population comprised health care workers who were taking AZT prophylaxis after accidental exposure to HIV-infected blood. Fourteen individuals were included into the study; seven of them discontinued treatment prematurely, five due to severe subjective symptoms. In case of one worker AZT had to be stopped due to severe neutropenia (800 cells /μl) with signs of upper respiratory tract infection. Four of 11 individuals taking AZT for at least 4 weeks developed neutropenia (2 WHO I, 1 WHO II, 1 WHO III). All other laboratory parameters stayed within normal range. In particular, no anemia was observed. In conclusion: Compared with other studies more neutropenias are observed. Due to side effects 50% of the workers discontinued AZT administration prematurely. The data presented herein show that AZT causes considerable side effects which must be weighed against the potential protective antiviral effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695694
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Chronotrope Wirkung von Calcium und Magnesium am isolierten Hundeherzen (1965)
    Springer
    Pflügers Archiv 284 (1965), S. 316-326 
    Details
    ISSN: 1432-2013
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 22 Herz-Lungen-Präparaten des Hundes wird die chronotrope Wirkung von Calcium und Magnesium untersucht. 1,8 mMol Ca++/l Vollblut haben einen Frequenzanstieg von 11,6 Schlägen/min zur Folge. Bei mehrmaliger Injektion dieser Dosis addieren sich die Frequenzzunahmen, bis die maximal wirksame Dosis zwischen 5,4 und 7,2 mMol Ca++/1 erreicht ist. Werden die Injektionen darüber hinaus fortgesetzt, so fällt die Frequenz wieder ab. Durch Vorbehandlung mit Reserpin, d. h. Entleerung der Katecholaminspeicher des Herzens, wird dieser Frequenzeffekt des Calciums nicht beeinträchtigt. Das Maximum der chronotropen Ca++-Wirkung ist durchschnittlich erst 1 min nach dem Maximum der inotropen Wirkung erreicht. Äquimolare Magnesium-Gaben (1,8 mMol) haben einen etwa gleich großen, jedoch vermindernden Frequenzeffekt. Bei wiederholter Gabe summiert sich dieser Effekt, jedoch tritt meistens nach etwa 5,4 mMol ein akuter starker Abfall der Herzfrequenz auf etwa halbe Werte ein. Dabei handelt es sich nicht um einen A-V-Block, da Vorhof und Kammer weiter koordiniert schlagen. 1,8 mMol Magnesium haben am Herz-Lungen-Präparat des Hundes keine deutliche Wirkung auf die Herzkraft.
    Notes: Summary In 22 heart-lung preparations of dogs the chronotropic effect of calcium and magnesium is studied. 1.8 mmol Ca++/l blood cause an increase in heart rate of 11.6 beats/min. Repeated injections of the same dose increase the heart rate until the maximal effective dose between 5.4 and 7.2 mmol Ca++/l is reached. Further injections result in rate decreases. Pretreatment with reserpine, i.e. by depletion of the cardiac catecholamine stores, does not influence the effect of calcium. Generally the maximum of the chronotropic calcium-effect is only reached 1 min after the maximum of the inotropic effect. Equimolar magnesium doses (1.8 mmol) have nearly the same quantitative effect, but decrease the heart rate. After repeated doses this effect sums up, but after about 5.4 mmol, it is regularly followed by an acute heavy decrease of the heart rate to nearly one half of the former values. This seems not to be an A-V-block, however, as atrium and ventricle continue beating coordinately. 1,8 mmol magnesium have no distinct effect on contractility in the canine heart-lung-preparation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363240
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    Saturable metabolism of continuous high-dose ifosfamide with Mesna and GM-CSF: A pharmacokinetic study in advanced sarcoma patients (1999)
    Springer
    Annals of oncology 10 (1999), S. 1087-1094 
    Details
    ISSN: 1569-8041
    Keywords: high-dose ifosfamide ; metabolism ; pharmacology ; sarcomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The aim of this study was to assess the pharmacology, toxicity and activity of high-dose ifosfamide/mesna ± GM-CSF administered by a five-day continuous infusion at a total ifosfamide dose of 12–18 g/m2 in adult patients with advanced sarcomas. Patients and methods: Between January 1991 and October 1992 32 patients with advanced or metastatic sarcoma were entered the study. Twenty-seven patients were pretreated including twenty-three with prior ifosfamide at less than 8 g/m2 total dose/cycle. In 25 patients (27 cycles) extensive pharmacokinetic analyses were performed. Results: The area under the plasma concentration-time curve (AUC) for ifosfamide increased linearly with dose while the AUC's of the metabolites measured in plasma by thin-layer chromatography did not increase with dose, particularly that of the active metabolite isophosphoramide mustard. Furthermore the AUC of the inactive carboxymetabolite did not increase with dose. Interpatient variability of pharmacokinetic parameters was high. Dose-limiting toxicity was myelosuppression at 18 g/m2 total dose with grade 4 neutropenia in five of six patients and grade 4 thrombocytopenia in four of six patients. Therefore the maximum tolerated dose was considered to be 18 g/m2 total dose. There was one CR and eleven PR in twenty-nine evaluable patients (overall response rate 41%). Conclusion: Both the activation and inactivation pathways of ifosfamide are non-linear and saturable at high-doses although the pharmacokinetics of the parent drug itself are dose linear. Ifosfamide doses greater than 14–16 g/m2 per cycle appear to result in a relative decrease of the active metabolite isophosphoramide mustard. These data suggest a dose-dependent saturation or even inhibition of ifosfamide metabolism by increasing high dose ifosfamide and suggest the need for further metabolic studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008386000547
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Acute hematologic toxicity and practicability of dose-intensified BEACOPP chemotherapy for advanced stage Hodgkin's disease (2000)
    Springer
    Annals of oncology 11 (2000), S. 1105-1114 
    Details
    ISSN: 1569-8041
    Keywords: BEACOPP ; chemotherapy ; dose intensification ; hematotoxicity ; Hodgkin's disease ; practicability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Evidence is recently accumulating that the novelBEACOPP (bleomycin (B), etoposide (E), adriamycin (A), cyclophosphamide (C),vincristine (O), procarbazine (P), prednisone (P)) chemotherapy is a highlyeffective treatment for advanced stage Hodgkin's disease. Two dose variantsof BEACOPP are currently tested in a phase III randomized multicenter trialof the GHSG. To enable more extensive testing of BEACOPP we characterized itspracticability regarding schedule adherence, acute hematotoxicity and need forsupportive treatment. Patients and methods:Data of 858 patients (6592 therapy cycles)from 184 participating institutions were evaluated. Planned total drug dosesof the baseline variant (arm 1) were 80, 2400, 200, 5200, 11.2, 5600 and 4480mg/m2 for B, E, A, C, O, P and P, respectively. Compared to arm 1,the doses of E, A and C in the dose-intensified variant (arm 2) were escalatedby factor 2.0, 1.4, 1.92, respectively, using G-CSF assistance. Stepwise dosereductions were specified in case of dose-limiting toxicities. Both variantsare given in eight three-weekly courses. Results:Median dose adherence (dose actually given relative toplanned arm 1 dose) in arm 1 was 1.0 for all drugs. Relative dose escalationof E, A, and C actually maintained in arm 2 was 1.83, 1.37 and 1.77 (medians),respectively, and 70% of patients maintained elevated dose levelsthroughout the entire treatment. Dose-limiting toxicities occurred in25% of cycles in arm 2, most frequently due to leukocytopenia andthrombocytopenia. Time courses of leukocytes in arm 2 showed more severe butnot more prolonged leukocytopenia compared with arm 1. WHO grades 3–4infections were documented in 2.1% (arm 1) and 3.1% (arm 2) ofall cycles. Erythrocytes were transfused in 6% (arm 1) and 28%(arm 2), platelets in 〈1% (arm 1) and 6% (arm 2) of allcycles. Conclusions:Both BEACOPP schemes are practicable in a largemulticenter setting. Despite increased hematotoxicity, moderate doseescalation is safe for the majority of the patients with G-CSF assistance andstandard supportive treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008301225839
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    Controlled multicenter trial of laparoscopic transabdominal preperitoneal hernioplasty vs Shouldice herniorrhaphy (1996)
    Springer
    Surgical endoscopy and other interventional techniques 10 (1996), S. 845-847 
    Details
    ISSN: 1432-2218
    Keywords: Inguinal hernia ; Laparoscopic repair ; Prosthetic mesh ; Shouldice repair ; Controlled trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In February 1993 a prospective randomized multicenter trial was initiated to compare laparoscopic transabdominal preperitoneal hernioplasty to Shouldice herniorrhaphy as performed by surgeons of nonspecialized clinics. Methods: Until January 1994, 87 patients with 108 hernias took part in the trial (43 Shouldice and 44 laparoscopic repairs). Results: The laparoscopic procedure took significantly longer than did the open operation but caused less pain as measured by pain analogue score and consumption of paracetamol and narcotics. The postoperative complication rate was 26% in the open and 16% in the laparoscopic group. The patients in the laparoscopic group were discharged earlier and their convalescence was shorter than after open hernia repair. There has been one early recurrence in the laparoscopic and two in the open group to date with a mean follow-up of 201 days. Conclusions: Laparoscopic hernia repair causes less pain than the conventional operation and enables the patient to return to full work and usual activities earlier. The recurrence rate will not be known for 5 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189547
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Controlled multicenter trial of laparoscopic transabdominal preperitoneal hernioplasty vs Shouldice herniorrhaphy (1996)
    Springer
    Surgical endoscopy and other interventional techniques 10 (1996), S. 845-847 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Inguinal hernia — Laparoscopic repair — Prosthetic mesh — Shouldice repair — Controlled trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In February 1993 a prospective randomized multicenter trial was initiated to compare laparoscopic transabdominal preperitoneal hernioplasty to Shouldice herniorrhaphy as performed by surgeons of nonspecialized clinics. Methods: Until January 1994, 87 patients with 108 hernias took part in the trial (43 Shouldice and 44 laparoscopic repairs). Results: The laparoscopic procedure took significantly longer than did the open operation but caused less pain as measured by pain analogue score and consumption of paracetamol and narcotics. The postoperative complication rate was 26% in the open and 16% in the laparoscopic group. The patients in the laparoscopic group were discharged earlier and their convalescence was shorter than after open hernia repair. There has been one early recurrence in the laparoscopic and two in the open group to date with a mean follow-up of 201 days. Conclusions: Laparoscopic hernia repair causes less pain than the conventional operation and enables the patient to return to full work and usual activities earlier. The recurrence rate will not be known for 5 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900174
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    Determining the minimum sample size required to obtain sufficient progeny with a desired genotype at two quantitative trait loci (1993)
    Springer
    Theoretical and applied genetics 87 (1993), S. 136-144 
    Details
    ISSN: 1432-2242
    Keywords: Sample size ; Quantitative trait loci ; Genotype ; Phenotypic classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In this paper we determine the minimum progeny sample size n needed to obtain, with probability α, at least m individuals of a desired two-locus genotype ℊ affecting quantitative traits. The two quantitative trait loci (QTLs) of interest may be linked or independent, with or without epistatic interaction between them. Parental genotypes may be known or unknown, and gene action at either locus may range from additive to overdominance. To reduce the required sample size, mating patterns that will produce a high proportion of desired progeny are suggested for different progeny genotypes and dominance levels. Based on the assumption of normally distributed quantitative trait expression, individuals can be classified into a genotype or genotypic group according to their phenotypic expressions. This technique is used to select both parents and progeny with unknown genotypes. Choice of parental classification criteria for a given quantitative trait affects classification accuracy, and hence the probability of obtaining progeny of the desired genotype. The complexity of this probability depends on the dominance level at each locus, the recombination fraction, and the awareness of parental genotypes. The procedure can be expanded to deal with more than two loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223757
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 20
    Electronic Resource
    Electronic Resource
    Differential activities of heterocyst ferredoxin, vegetative cell ferredoxin, and flavodoxin as electron carriers in nitrogen fixation and photosynthesis in Anabaena sp. (1995)
    Springer
    Photosynthesis research 43 (1995), S. 35-40 
    Details
    ISSN: 1573-5079
    Keywords: heterocyst ferredoxin ; vegetative cell ferredoxin ; flavodoxin ; nitrogen fixation ; NADP+ photoreduction ; pyruvate ferredoxin/flavodoxin oxidoreductase ; electron transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In cyanobacteria an increasing number of low potential electron carriers is found, but in most cases their contribution to metabolic pathways remains unclear. In this work, we compare recombinant plant-type ferredoxins from Anabaena sp. PCC 7120, encoded by the genes petF and fdxH, respectively, and flavodoxin from Anabaena sp. PCC 7119 as electron carriers in reconstituted in vitro assays with nitrogenase, Photosystem I, ferredoxin-NADP+ reductase and pyruvate-ferredoxin oxidoreductase. In every experimental system only the heterocyst ferredoxin catalyzed an efficient electron transfer to nitrogenase while vegetative cell ferredoxin and flavodoxin were much less active. This implies that flavodoxin is not able to functionally replace heterocyst ferredoxin. When PFO-activity in heterocyst extracts was reconstituted under anaerobic conditions, both ferredoxins were more efficient than flavodoxin, which suggested that this PFO was of the ferredoxin dependent type. Flavodoxin, synthesized under iron limiting conditions, replaces PetF very efficiently in the electron transport from Photosystem I to NADP+, using thylakoids from vegetative cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00029460
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...