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  • 11
    Electronic Resource
    Electronic Resource
    Corrosion defects of TbFeCo films in magneto-optical disks
    Amsterdam : Elsevier
    Journal of Magnetism and Magnetic Materials 113 (1992), S. 248-256 
    Details
    ISSN: 0304-8853
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0304-8853(92)91274-W
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  • 12
    Electronic Resource
    Electronic Resource
    Calculation of the electronic structure of transition metal impurities in semiconductors
    Amsterdam : Elsevier
    Journal of Magnetism and Magnetic Materials 31-34 (1983), S. 553-554 
    Details
    ISSN: 0304-8853
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-8853(83)90574-7
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  • 13
    Electronic Resource
    Electronic Resource
    Structures of cyclocarbamides A and B, new plant growth regulators from streptoverticillium sp.
    Amsterdam : Elsevier
    Tetrahedron Letters 27 (1986), S. 1161-1164 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)84205-7
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  • 14
    Electronic Resource
    Electronic Resource
    BCG induced killer cell activity (1988)
    Springer
    Urological research 16 (1988), S. 351-355 
    Details
    ISSN: 1434-0879
    Keywords: Intravesical BCG ; Peripheral blood mononuclear cells ; Killer activity against natural killer cell (NK) resistant tumors, NK type precursor and effector cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the mechanism of Bacillus de Calmette Guérin (BCG) bladder instillation therapy, the killer cell activity induced in peripheral blood mononuclear cells (PBMNCs) after BCG instillation was examined. Significant cytotoxic activity against natural killer (NK) cell resistant target tumor cells was detected after 3 days of instillation. To characterize this BCG induced cytotoxic activity further, human PBMNCs were cultured with BCG in vitro. From 24 h maximum cytotoxicity was obtained and continued for 3 days, then decreased slightly. Neither a DNA synthesis inhibitor Cytosine-arabinoside (Ara-C) nor a cytotoxic T cell (CTL) generation inhibitor Cyclosporine A inhibited this killer cell activation. Monoclonal antibody treatment revealed that both precursor and effector cells are Leu1-, 3a-, 7+, 11b+. The recognition specificity from cold target competition experiments was selective. Taken together NK type precursor was activated with BCG into NK type effector which has wider spectrum of target cells than usual NK cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256041
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  • 15
    Electronic Resource
    Electronic Resource
    The effects of S1319, a novel marine sponge-derived β2-adrenoceptor agonist, on IgE-mediated activation of human cultured mast cells (2000)
    Springer
    Inflammation research 49 (2000), S. 86-94 
    Details
    ISSN: 1420-908X
    Keywords: Key words:β-adrenoceptor agonist — Mast cells — Tryptase — TNF-α— Protein tyrosine phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: This study aimed to evaluate the abil-ity of S1319 (4-hydroxy-7-[1-(1-hydroxy-2-methylamino) ethyl]-1,3-benzothiazol-2(3H)-one acetate), a novel β 2-adrenoceptor selective agonist derived from marine sponge, to inhibit IgE-mediated activation of human cultured mast cells (HCMC) in vitro.¶Materials and Methods: We examined the effect of S1319 (racemate) on tryptase release and tumor necrosis factor- α (TNF-α) production in HCMC generated from human cord blood cells, after cross-linking of high affinity immunoglobulin E receptors (FcεRI), compared with those of the non-selective β-adrenoceptor agonist, isoproterenol (R-isomer), the selective β 2-adrenoceptor agonist, salbutamol (racemate), and the selective and long-acting β 2-adrenoceptor agonist, formoterol (racemate). We also evaluated the effect of S1319 on the intracellular cAMP level, inositol phosphate production and protein tyrosine phosphorylation in HCMC.¶Results: S1319 and β-adrenoceptor agonists inhibited the IgE-mediated release of tryptase. Approximate IC50 values of S1319, formoterol, isoproterenol and albuterol for the inhibition of tryptase release were 0.51 ± 0.12, 0.15 ± 0.1, 0.80 ± 0.09, and 28 ± 32.4 nM, respectively. S1319 and β-adrenoceptor agonists also inhibited TNF-α production by HCMC in a concentration-dependent manner. Approximate IC50 values of S1319, formoterol and isoproterenol for the inhibition of TNF-α production were 0.19 ± 0.03, 0.28 ± 0.02 and 0.32 ± 0.03 nM, respectively. S1319 caused a concentration-dependent increase in total cell cyclic AMP levels in HCMC. On the other hand, S1319 inhibited the accumulation of inositol 1,4,5-triphosphate and IgE-mediated protein tyrosine phosphorylation of 42-kDa protein, p42 mitogen activated protein (MAP) kinase (ERK-2).¶Conclusion: These results indicate that S1319 and β-adrenoceptor agonists are potent inhibitors of the IgE-mediated release of mediators from HCMC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050563
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  • 16
    Electronic Resource
    Electronic Resource
    Measurement of the area of the anterior horn of the right lateral ventricle for the diagnosis of brain atrophy by CT (1983)
    Springer
    Neuroradiology 25 (1983), S. 23-27 
    Details
    ISSN: 1432-1920
    Keywords: Computed tomography ; brain atrophy ; area of the anterior horn of the right lateral ventricle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The area of the anterior horn of the right lateral ventricle and five ventricular indices:(1) maximum width of the anterior horns, (2) minimum width of the anterior horns, (3) sum of these maximum and minimum widths, (4) ventricular index, and (5) cella media index were measured from the CT scans of 198 cases considered to be “normal”. The area of the right anterior horn and indices 1–4 were measured on the slice which most clearly showed Monro's foramina and index 5 was measured on the slice 2 cm above. The size of the ventricular system increased steadily with age. The sum of the maximum and minimum widths of the anterior horns was most highly correlated with the area of the right anterior horn. Using this ventricular index, we graded brain “atrophy” in each age group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327475
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  • 17
    Electronic Resource
    Electronic Resource
    Sleep apnoea in well-controlled myasthenia gravis and the effect of thymectomy (1998)
    Springer
    Journal of neurology 245 (1998), S. 77-80 
    Details
    ISSN: 1432-1459
    Keywords: Key words Myasthenia gravis ; Sleep apnoeas ; Thymectomy ; Polysomnography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We conducted overnight polysomnographic sleep studies of 16 patients (5 men and 11 women) with clinically well-controlled myasthenia gravis (MG). The subtypes of MG were IIA (3 patients), IIB (11 patients), IV (1 patient) and V (1 patient). Twelve patients were found on polysomnography to have obstructive and/or central types of the sleep apnoeas (SA). Their mean age was 42.4, SD 16.4 years, and the mean duration of MG was 7.4, SD 6.96 years. SA was not detected in 4 patients whose mean age was 30.8, SD 10.71 years and who had manifested MG for a mean duration of only 0.9, SD 0.65 years. Thus, patients with a longer duration of MG tended to have more SA. In 9 of the 12 SA patients, polysomnographic studies were repeated following thymectomy. SA had resolved in 6 patients, but persisted in 3. These findings suggest that SA is a possible clinical manifestiation of MG and that nocturnal dysfunction of both peripheral and central colinergic systems may be involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050181
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  • 18
    Electronic Resource
    Electronic Resource
    Idiopathic autonomic neuropathy associated with esophageal dilatation (2000)
    Springer
    Journal of neurology 247 (2000), S. 215-217 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050566
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  • 19
    Electronic Resource
    Electronic Resource
    Microneurographic analysis of muscle sympathetic nerve activity in amyotrophic lateral sclerosis (1993)
    Springer
    Clinical autonomic research 3 (1993), S. 131-135 
    Details
    ISSN: 1619-1560
    Keywords: Amyotrophic lateral sclerosis ; Microneurography ; Muscle sympathetic nerve activity ; Blood pressure ; Heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Muscle sympathetic nerve activity by (microneurograph) blood pressure and heart rate has been studied in patients with amyotrophic lateral sclerosis and in age-matched normal subjects (controls) at rest and during head-up tilt. Muscle sympathetic nerve activity in amyotrophic lateral sclerosis patients was significantly increased at rest unlike controls. There was no correlation between muscle sympathetic nerve activity and age in the patients with amyotrophic lateral sclerosis. Elevated muscle sympathetic nerve activity was present mainly in younger patients. There were no differences between blood pressure or heart rate in either group at rest or during head-up tilt in amyotrophic lateral sclerosis. The increase in muscle sympathetic nerve activity following tilt in the amyotrophic lateral sclerosis patients was less than in the controls, but they had no postural hypotension. The possible reasons for this observation of increased muscle sympathetic nerve activity at rest in amyotrophic lateral sclerosis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01818998
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  • 20
    Electronic Resource
    Electronic Resource
    Electronic structure of positive muon in silicon (1984)
    Springer
    Hyperfine interactions 18 (1984), S. 581-584 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The spin polarized electronic structure around a positive muonμ + at the tetrahedral interstitial site of silicon is calculated by use of the LCAO-Green's function method and the local spin density functional formalism. The bonding hyper deep impurity state below the valence band and the antibonding deep one in the gap caused by the strong sp hybridization in the majority spin band give the most large contribution to the hyperfine coupling constant ofμ +. The reduction of the hyperfine coupling constant,A, experienced byμ + at absolute zero is calculated to be 0.406 in satisfactory agreement with the experimental value of 0.405 ± 0.026 or 0.450 ± 0.020.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064871
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