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  • 1
    Digitale Medien
    Digitale Medien
    Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 637-640 
    Details
    ISSN: 1432-1041
    Schlagwort(e): urapidil ; metoprolol ; antihypertensive treatment ; exercise test ; haemodymic effects ; side-effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The hypertensive effect of urapidil, a new antihypertensive agent that acts via central and peripheral alpha-adrenoceptors, has been compared with that of metoprolol in 40 patients with mild essential hypertension. Blood pressure was significantly reduced by both drugs, while the heart rate was reduced only after metoprolol. The increases in systolic blood pressure and heart rate caused by three progressive work loads of bicycle exercise were not affected during urapidil, whereas both were reduced by metoprolol. A slight reduction in forced expiratory volume was observed in some patients during treatment with the beta-blocker. There was no case of orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare and negligible with both drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00608208
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  • 2
    Digitale Medien
    Digitale Medien
    766 cases of oral cleft in Italy (1994)
    Springer
    European journal of epidemiology 10 (1994), S. 317-324 
    Details
    ISSN: 1573-7284
    Schlagwort(e): Epidemiology ; Genetics ; Oral clefts ; Registers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Epidemiological and genetic variables for oral clefts were analysed for the years 1981–1989 in a case-control study of congenital malformations in the Emilia Romagna, Veneto, and Friuli regions, and in the Trento and Bolzano hospitals. Birth prevalence for all cases of cleft lip with or without cleft palate (CL(P)) was 8.2 per 10,000 births, and that for cleft palate only (CP) was 6.1 per 10,000. Coexisting abnormalities were found in 23% of CL(P) cases and in 43% of CP. No clusters in time or space were detected. For isolated clefts, a predominance of males among CL(P) and of females among CP was found; epilepsy was the only maternal risk factor correlated with clefts, and an association between clefting and consanguinity was found. Empirical recurrence risks were calculated in both isolated CL(P) and CP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01719356
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  • 3
    Digitale Medien
    Digitale Medien
    Type 2 atrophy in a pentazocine addicted patient (1979)
    Springer
    Neurological sciences 1 (1979), S. 113-118 
    Details
    ISSN: 1590-3478
    Schlagwort(e): pentazocine-type 2 atrophy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Sommario Viene descritto un caso di abuso di pentazocine (450 mg die) in un uomo di 33 a. Lo studio bioptico muscolare dal punto di vista istochimico e istografico quantitativo ha dimostrato una atrofia delle fibre del tipo 2. Si suggerisce la possibilità di un danno tossico generalizzato da parte della pentazocina.
    Notizen: Abstract A case of a 33-year-old pentazocine-addicted man (450 mg daily) is described. Histochemical and quantitative histographic analyses of the muscle biopsy disclosed type 2 atrophy. We consider that this indicates that there is a generalized toxic effect of pentazocine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02336853
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  • 4
    Digitale Medien
    Digitale Medien
    Familial adult amyotrophic lateral sclerosis: report of cases (1992)
    Springer
    Neurological sciences 13 (1992), S. 75-79 
    Details
    ISSN: 1590-3478
    Schlagwort(e): Epidemiology ; province of Pavia ; familial ALS-sporadic ALS ; inheritance ; variable penetrance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Sommario Abbiamo esaminato otto casi di SLA familiare (Sclerosi Laterale Amiotrofica) appartenenti a tre diverse famiglie isolate nella nostra provincia e ricoverati nel nostro Istituto tra il 1970 ed il 1989. I criteri clinici di diagnosi sono stati soddisfatti in tutti i casi e l'EMG è stato eseguito in 6 casi su 8. Quattro casi mostravano un esordio di tipo classico e quattro un esordio di tipo bulbare. L'età media di insorgenza della malattia nelle tre famiglie era di 65.7+10.6 anni. La sopravvivenza media era di 19.1+9.2 mesi. La modalità di trasmissione era autosomica dominante con penetranza variabile. In due famiglie erano affetta due diverse generazioni, nella terza famiglia una sola. Fattori ambientali non sembrano essere coinvolti nello sviluppo della malattia. Ulteriori studi genetici potranno far luce sulla patogenesi della SLA familiare.
    Notizen: Abstract We examined 8 cases of familial ALS (amyotrophic lateral sclerosis) in three different families from our province, admitted to our hospital between 1970 and 1989. Clinical criteria for diagnosis were satisfied in all cases; EMG was performed in 6 out of 8 patients. 4 cases showed classical onset and 4 cases bulbar onset. The average age at onset was 65.7+10.6 years. The average survival was 19.1+9.2 months. In two families two generations were affected, in the other only one. The mode of transmission was found to be autosomal dominant with variable penetrance. Neither environmental nor toxic factors seemed to be involved in the development of the illness. Genetic investigations may help to elucidate the pathogenesis of familial ALS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02222892
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