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The effect of cyproheptadine on insulin biosynthesis (1985)

Kikkawa, R. ; Duvillard, D. ; Stauffacher, W.

Springer

Cellular and molecular life sciences 41 (1985), S. 80-82

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ISSN: 1420-9071

Keywords: Pancreatic islets, rat ; insulin biosynthesis ; cyproheptadine

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The effect of a potent antiserotonin-antithistaminic compound, cyproheptadine (CPH) on insulin biosynthesis was studied in pancreatic islets isolated from CPH-treated rats. Though insulin content of islets was markedly reduced in CPH-treated rats, the incorporation of radiolabeled leucine into proinsulin and insulin fractions was not affected with respect to the rate and amount. It is concluded that CPH may deplete insulin content of the islets through causing the leakage of insulin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02005886

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