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Digitale Medien

The effect of cyproheptadine on insulin biosynthesis (1985)

Kikkawa, R. ; Duvillard, D. ; Stauffacher, W.

Springer

Cellular and molecular life sciences 41 (1985), S. 80-82

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Details

ISSN: 1420-9071

Schlagwort(e): Pancreatic islets, rat ; insulin biosynthesis ; cyproheptadine

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The effect of a potent antiserotonin-antithistaminic compound, cyproheptadine (CPH) on insulin biosynthesis was studied in pancreatic islets isolated from CPH-treated rats. Though insulin content of islets was markedly reduced in CPH-treated rats, the incorporation of radiolabeled leucine into proinsulin and insulin fractions was not affected with respect to the rate and amount. It is concluded that CPH may deplete insulin content of the islets through causing the leakage of insulin.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02005886

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