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  • 1
    Electronic Resource
    Electronic Resource
    Age-related changes in skin wrinkles assessed by a novel three-dimensional morphometric analysis (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background A system has been developed whereby the morphology of the skin surface can be evaluated directly in three dimensions. This system employs a non-invasive device that utilizes white light of halogen origin, and which allows the computation of wrinkle depth and width, and other parameters of skin surface morphology. Using innovative engineering, an optical system has been devised so that light is transmitted via a slit and can be used to measure not only replicas of the skin but also the skin surface directly. The measurement area is 6·4 × 6·4 mm, and the theoretical resolution with a × 50 magnification lens is within 12·5 µm. Objectives To use this system to study age-related changes in the morphology of wrinkles at the eye corner areas of women of varying ages. Methods One hundred and one healthy women (age range 20–80 years) residing in the Tokyo area were the subjects used in this study. Results Wrinkles demonstrated a rapid increase in depth in women aged 40 years or older, and plateaued at the age of 60 years. Surface morphology parameters yielded results similar to those of age-related changes in wrinkles. Conclusions This new analytical system provides a rapid and convenient non-invasive method to evaluate skin surface morphology in three dimensions, especially with respect to wrinkle formation. The results obtained using this system provide a deeper insight into the mechanistic relationship between wrinkles and skin elasticity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04874.x
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  • 2
    Electronic Resource
    Electronic Resource
    Equilibrium and kinetics of thermal unfolding of yeast 5.8S ribosomal RNA in aqueous salt solutions
    Amsterdam : Elsevier
    International Journal of Biological Macromolecules 5 (1983), S. 26-32 
    Details
    ISSN: 0141-8130
    Keywords: 5.8S RNA ; Yeast ; differential melting ; helix-coil transition ; structure model ; temperature jump ; thermal unfolding
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0141-8130(83)90074-0
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  • 3
    Electronic Resource
    Electronic Resource
    Study of HLA class I, class II and complement genes (C2, C4A, C4B and BF) in Japanese psoriatics and analysis of a newly-found high-risk haplotype by pulsed field gel electrophoresis (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 281-284 
    Details
    ISSN: 1432-069X
    Keywords: Psoriasis ; HLA ; Complement genes ; Supratype ; Pulsed field gel electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Genetic polymorphisms of HLA antigens and HLA-linked serum complement components (C2, C4A, C4B and BF) were investigated in 79 Japanese patients suffering from psoriasis. HLA typing revealed increased frequencies of HLA-A1, A2, B39, Bw46, Cw6, Cw7 and Cw11. Among complement components, positive associations were obtained with C4A4 and C4B2 and a negative association with BFF. The major histocompatibility complex haplotype (supratype), HLA-A2-Cw11-Bw46-C2C-BFS-C4A4-C4B2-DRw8 is purported to be a new high-risk haplotype in Japanese patients with psoriasis. Analysis of patients with this supratype via pulsed field gel electrophoresis showed the existence of specific, extensive DNA deletions near HLA-DR genes, but no disease-specific patterns could be observed by means of this technique. The newly-found high-risk haplotype indicates racial and ethnic differences among psoriatic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00376613
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    Paper (German National Licenses)
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