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  • 1
    Electronic Resource
    Electronic Resource
    Space-charge wave propagation in inhomogeneous waveguides (1985)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 28 (1985), S. 358-365 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this paper, an account is presented of an investigation into the propagation of large amplitude space-charge waves in an inhomogeneous waveguide. The study is motivated by the possibility of using these waves for the collective acceleration of ions. Measurements are reported that show an increase in the wave phase velocity as the guide diameter, and hence the effective plasma frequency is decreased. Results are also presented which show that the wave phase velocity is a function of its amplitude, and that large amplitude, nonlinear waves propagate more slowly than those described by linear theory. The results demonstrate that it is possible to control the wave propagation characteristics, and therefore indicate the electron-beam-supported slow space-charge waves provide a suitable medium for collective ion acceleration. Finally, a summary is given of possible advantages of an electron beam-wave accelerator over those using externally generated rf fields.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.865156
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  • 2
    Electronic Resource
    Electronic Resource
    Parametric growth of space charge waves using a self-biased electrostatic wiggler (1988)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 31 (1988), S. 2037-2046 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: An investigation is reported on the use of parametric scattering from an electrostatic wiggler for the growth of space charge waves. This investigation extends previous work on slow space charge wave generation and propagation in inhomogeneous waveguides. Observations show that the scattering technique may be used for the growth of large amplitude waves and that this technique permits wave growth at all values of interest for the ratio of beam to limiting current.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.866653
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  • 3
    Electronic Resource
    Electronic Resource
    Oscillatory convection in low aspect ratio Czochralski melts
    Amsterdam : Elsevier
    Journal of Crystal Growth 134 (1993), S. 116-139 
    Details
    ISSN: 0022-0248
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-0248(93)90016-P
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  • 4
    Electronic Resource
    Electronic Resource
    Numerical and experimental study of a solid pellet feed continuous Czochralski growth process for silicon single crystals
    Amsterdam : Elsevier
    Journal of Crystal Growth 131 (1993), S. 247-264 
    Details
    ISSN: 0022-0248
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-0248(93)90420-2
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  • 5
    Electronic Resource
    Electronic Resource
    Immunosuppression without prednisone after liver transplantion is safe and associated with normal early graft function: preliminary results of a randomized study (1998)
    Springer
    Transplant international 11 (1998), S. S267 
    Details
    ISSN: 1432-2277
    Keywords: Key words Liver transplantation ; Immunosuppression ; Prednisone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prednisone has been commonly considered the mainstay of immunosuppressive therapy after liver transplantation. Recent data suggest that prednisone withdrawal late after transplant reduces complications without affecting graft function. We report here the preliminary results of an open-label, randomized study aimed at investigating whether prednisone therapy can be completely avoided during the first 3 months after transplantation. Twenty-seven consecutive patients were randomized to receive double (group A: cyclosporine and azathioprine) or triple (group B: prednisone, cyclosporine, and azathioprine) immunosuppressive therapy after liver transplantation. Six patients died within the first 3 weeks in each group and were excluded from the calculations. The present results refer to 10 patients in group A and 11 in group B. The actuarial 1-year survival did not differ between the two groups (90.9 % vs 88.8 %). There were no differences with respect to infectious complications or episodes of histological acute graft rejections. Only one severe acute rejection occurred in group A and two in group B. During the first month after transplant, liver and kidney functions tended to be better in the group of patients treated without prednisone, although there were no differences in the mean cyclosporine blood levels. These data, though preliminary, indicate that early immunosuppression without the use of prednisone is safe and tends to be associated with improved liver and renal functions compared to conventional triple therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050475
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  • 6
    Electronic Resource
    Electronic Resource
    Conventional salvage chemotherapy vs. high-dose therapy with autografting for recurrent or refractory Hodgkin's disease patients (2000)
    Springer
    Annals of hematology 79 (2000), S. 79-82 
    Details
    ISSN: 1432-0584
    Keywords: Key words Autograft ; Chemotherapy ; Hodgkin's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Despite progress that has been made in curing Hodgkin's disease (HD), patients whose first remission is brief and those resistant to first-line chemotherapy still have a poor outcome. We retrospectively reviewed data from 29 patients with HD in first relapse or refractory to first-line chemotherapy. Following failure, all patients received three cycles of ifosfomide, epirubicin, and etoposide (IEV); moreover, 11 patients received a conditioning regimen followed by autografting. Of the 18 patients treated with IEV, eight (44%) are alive; nine died of disease progression, and one died of hematologic toxicity. The 24-month overall survival (OS), relapse-free survival (RFS), and event-free survival (EFS) are 18%, 44%, and 22%, respectively. Of the 11 patients treated with IEV and autografting, ten are alive (90%) and one patient died of progressive disease. The 29-month OS, RFS, and EFS are 91%, 71%, and 56%, respectively. Our results confirm data showing that patients with relapsed or resistant HD achieve a significantly better OS and EFS if treated with high-dose therapy and autografting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050014
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  • 7
    Electronic Resource
    Electronic Resource
    Peripheral neuroectodermal tumor of the chest (Askin tumor) as secondary neoplasm after Hodgkin's disease: A case report (1994)
    Springer
    Annals of hematology 68 (1994), S. 311-313 
    Details
    ISSN: 1432-0584
    Keywords: Hodgkin's disease ; Malignant peripheral neuroectodermal tumors Computed tomography ; Ultrasonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors present the case of a 20-yearold woman who developed a peripheral neuroectodermal neoplasm of the thoracopulmonary region (Askin tumor) 7 years after achieving complete remission of stage-IV Hodgkin's disease. The previous treatment had consisted of eight courses of alternating MOPP/ ABVD combined with involved-field 20-Gy radiotherapy. The second neoplasm appeared in a nonirradiated area of the chest wall, with erosion of the ribs as shown by sonography and computed tomography. The histological pattern was in accordance with a generic diagnosis of a malignant small cell tumor; the immunostaining positivity of the neoplastic cells for the neuron-specific enolase allowed us to make the diagnosis of a tumor with a neuroectodermal origin. Partial resection of the neoplasm and four courses of chemotherapy including adriamycin, cisplatin, and ifosfamide induced a complete remission, confirmed by surgical restaging. She is alive and well 10 months after the completion of therapy. The clinical, radiological, and microscopic features of this tumor occurring as a secondary neoplasm after Hodgkin's disease are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695039
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  • 8
    Electronic Resource
    Electronic Resource
    Acute nonlymphocytic leukemia: onset after treatment for Hodgkin's disease (1997)
    Springer
    Annals of hematology 74 (1997), S. 103-110 
    Details
    ISSN: 1432-0584
    Keywords: Key words Hodgkin's disease ; Acute nonlymphocytic leukemia ; Risk factors ; Radiotherapy ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  This study was undertaken to examine the influence of various factors on the occurrence of acute nonlymphocytic leukemia (ANLL) in a group of long-term survivors of Hodgkin's disease (HD). From 1972 to 1992, 1045 patients with HD were assessed and treated at the Department of Radiation Oncology, the Institute of Radiology, and the Department of Human Biopathology, Hematology Section, University of Rome "La Sapienza." The average follow-up was 72 months. For a more accurate calculation of the risk of ANLL occurrence, the patients were first divided into three subgroups according to initial treatment and then according to the total treatment they had received. Moreover, to establish the probable connection between leukemia and splenic treatment the patients were also divided into three subgroups (splenectomy, splenic irradiation, and no splenectomy/no splenic irradiation). Sixteen cases of ANLL were recorded, giving an overall risk of 0.2% at 5 years and 3.4% at 20 years. In 12 patients overt leukemia was preceded by a myelodysplastic syndrome. Five cases had evaluable chromosome analysis. Clonal chromosome abnormalities were demonstrated in two patients, whereas three patients showed an apparently normal karyotype. Bone marrow agar cultures were analyzed in two patients and were abnormal in both cases. In the radiotherapy (RT) group, the cumulative risk was 0.4% at 10 years and 3.2% at 15 and 20 years; in the chemotherapy (CT) group it was 1.2% at 10, 15, and 20 years; in the combined group it was 3.7% at 10 years and 4.9% at 15 and 20 years. In the multivariate analysis, MOPP treatment with or without RT is a statistically significant variable for ANLL occurrence (p=0.009). This study demonstrates that splenic treatment does not lead to ANLL. Treatment with MOPP alone and with MOPP plus RT can increase the risk of ANLL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050266
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  • 9
    Electronic Resource
    Electronic Resource
    Luteinizing hormone pulsatility and computer-assisted analysis of sperm features in patients with Hodgkin's disease (1996)
    Springer
    Journal of cancer research and clinical oncology 122 (1996), S. 416-420 
    Details
    ISSN: 1432-1335
    Keywords: Hodgkin's disease ; Hypothalamic/hypophyseal/gonadal axis ; Luteinizing hormone pulsatility ; Sperm analysis ; Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this work was to characterize further the impairment of the reproductive function reported in untreated male patients with Hodgkin's disease. We evaluated the pattern of luteinizing hormone pulsatility and unconventional sperm features by computer-assisted sperm analysis (CASA) in 20 adult patients affected by biopsy-proven Hodgkin's disease before they were submitted to any therapeutic approach. Changes of luteinizing hormone pulsatility were documented and consisted mainly in an increase in pulse number in comparison with control subjects (P〈0.05). On CASA, 1/3 of the patients showed a reduction in the sperm number but, when motility, velocity and linearity of progression were evaluated, the number of patients with seminal alterations rose to 2/3. Sperm velocity and linearity were already impaired in stages I and II, whereas sperm number was reduced only in stage III. Symptomatic patients, regardless of the stage, showed a significant deterioration of all parameters. Our study supports the view that in Hodgkin's disease, before any treatment, a disorder of the reproductive system is present, both at hypothalamic/hypophysial and the gonadal level, having a pathogenesis that deserves to be elucidated by further study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212881
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  • 10
    Electronic Resource
    Electronic Resource
    Isolation and selection of phenol - degrading microorganisms from an industrial effluent (1984)
    Springer
    Biotechnology letters 6 (1984), S. 601-606 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Among 12 bacterial and fungal isolates from a phenol-containing effluent, an Acinetobacter sp. and a Fusarium flocciferum strain could be adapted to growth on up to lg/1 of phenol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00135690
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