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  • 1
    Electronic Resource
    Electronic Resource
    Attempt to Improve Wound Healing Considering the Timing of Suture Removal and the Dressing (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction:  In the surgical field, “suture removal on 7 days after surgery” and “daily disinfection and coverage with gauze” have been customs. The timing of suture removal and the postoperative wound treatment were devised, and their effect on wound healing was compared with the conventional method.Method:  The abdominal incision was divided into two parts, one half of the suture was removed on 3 days after surgery, the other half of the suture was removed on 7 days after surgery, and the conditions of the wound were compared between 7 and 14 days after surgery. In addition, the skin was disinfected only immediately before incision, and the closed dressing was given on the wound.Results:  There were no differences in the degree of skin approximation, the degree of redness, subcutaneous swelling, pain and postoperative scar between both days. However, the suture removal on 3 days gave no scar of suture, which was better cosmetically. The frequency of treatments also decreased, which led to cost reduction.Discussion:  Since the wound is covered with epithelial cells in 48 hours, the suture removal on 3 days and the closed dressing are desirable in the abdominal incision to which no especially strong stress is added from the viewpoint of wound healing. In addition, this method is better than the conventional method from the aspect of cosmetics and cost reduction. We will investigate this method further in the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130116ad.x
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of lymphocyte subsets infiltrating gastric carcinoma after mitomycin C administration (1992)
    Springer
    Cancer immunology immunotherapy 35 (1992), S. 297-301 
    Details
    ISSN: 1432-0851
    Keywords: Immunohistochemistry ; Lymphocyte subsets ; Tumor-infiltrating lymphocyte ; Mitomycin C ; Gastric carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The intensity of lymphoid cell infiltration and distribution of lymphocyte subsets in tumors were investigated immunohistochemically on tumor tissues obtained from 11 patients with gastric carcinoma, who had been treated with mitomycin C (MMC), 12 mg/m2, i.v. 5 days before operation. The results were compared with those obtained from 24 untreated patients as controls. In the tumor tissues from pretreated patients, the intensity of lymphoid infiltration was not significantly different from that of untreated patients. However, high-grade infiltration of CD4+ cells was observed in 55% of pretreated patients, whereas only 8% of control patients exhibited the high-grade infiltration (P 〈0.02). Since the CD8+ cell infiltration was not significantly altered, the ratio of CD4+ to CD8+ cells was more frequently estimated to be more than 1 in patients pretreated with MMC, as compared to untreated controls (P 〈0.02). Further, CD25+ cells in pretreated tumor tissues were more predominant than those in control tumor tissues (P 〈0.05). These results suggest that MMC administration induces these alterations in lymphocyte subsets in tumor tissue in patients with gastric carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01741141
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  • 3
    Electronic Resource
    Electronic Resource
    Correlation of eosinophilia with clinical response in patients with advanced carcinoma treated with low-dose recombinant interleukin-2 and mitomycin C (1992)
    Springer
    Cancer immunology immunotherapy 35 (1992), S. 246-250 
    Details
    ISSN: 1432-0851
    Keywords: Eosinophilia ; Antitumor response ; Interleukin-2 ; Mitomycin C ; Advanced carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On the basis of our clinical findings that the ability of cancer patients to generate lymphokine-activated killer cells became markedly augmented after mitomycin C administration, we designed a treatment regimen comprising mitomycin C 12 mg/m2, i.v. on day 1 and recombinant interleukin-2 700 U/m2 (8000 IU/kg), i.v. every 12 h from day 4 through day 8. The treatment course was repeated at almost 7-day intervals. Altogether 33 patients with advanced carcinoma, including mainly gastrointestinal carcinoma, were treated with this regimen. Of these, 10 had a partial response (PR) and 4 had a minor response (MR). Since eosinophil counts peaked 1 day after either the first or second course of the therapy, the posttreatment values were compared to each pretreatment level, with regard to the clinical antitumor response to this treatment. When patients who showed PR were defined as responders, absolute eosinophil counts and the percentages of eosinophils in responders after both the first and second courses of the therapy were significantly greater than each pretreatment value or the posttreatment level in nonresponders. Further, these findings were almost identical, when both PR and MR were considered to be a true remission and therefore patients who exhibited PR or MR were defined as responders, although the difference between posttreatment levels of eosinophils in responders and nonresponders was not significant at the second course. These results indicate that eosinophilia induced by this treatment correlates with the clinical response to this therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01789330
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  • 4
    Electronic Resource
    Electronic Resource
    Cytotoxic cell function and phenotypic analysis of peripheral blood mononuclear cells in cancer patients treated with low-dose interleukin-2 and mitomycin C (1993)
    Springer
    Cancer immunology immunotherapy 37 (1993), S. 220-226 
    Details
    ISSN: 1432-0851
    Keywords: Cytotoxic activity ; Phenotypic analysis ; Peripheral blood mononuclear cell ; Interleukin-2 ; Mitomycin C ; Clinical response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We previously found that the ability of peripheral blood mononuclear cells (PBM) of cancer patients to generate lymphokine-activated killer (LAK) cells became remarkably augmented after mitomycin C administration. On the basis of the clinical finding, we designed a treatment regimen comprised of 12 mg/m2 mitomycin C i. v. on day 1 and 700 U/m2 recombinant interleukin-2 (IL-2) i.v. every 12 h from day 4 through day 8. Of 25 patients with advanced carcinoma, 9 had a partial response and 3 had a minor response. Cytotoxic cell function, including natural killer activity, lymphokine-activated killer (LAK) activity, and the ability to generate LAK cells, and lymphocyte subsets in PBM was measured 1 day before and after either the first or second course of this therapy. The relationship between these parameters and the clinical antitumor response to this treatment was examined. Although the cytotoxic activities were significantly augmented after either the first or second treatment course, no positive correlation was observed between the changes in these cytotoxic activities and the clinical response to this therapy, when patients who either showed a partial response or whose disease remission was partial or minor were defined as responders. Further, phenotypic analysis showed a significant increase in CD2+, CD3+ CD4+ and CD4+Leu8− cells after the firs course, and CD25+ cells after either the first or second course of this treatment. The precentages of CD2+ and CD25+ cells were significantly elevated only in responders but not in nonresponders, suggesting the increase in these subsets was related to clinical response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01518514
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  • 5
    Electronic Resource
    Electronic Resource
    Quantitative analysis of cytokine mRNA expression in peripheral blood mononuclear cells following treatment with interleukin-2 (1997)
    Springer
    Cancer immunology immunotherapy 44 (1997), S. 329-334 
    Details
    ISSN: 1432-0851
    Keywords: Key words Cytokine ; Quantitative RT-PCR ; Interleukin-2 ; Interleukin-1 ; Tumor necrosis factor α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  After activation with interleukin-2 (IL-2), peripheral blood mononuclear cells (PBMC) have been reported to induce the expression of mRNA coding various cytokines, including interleukin(IL)-1α, -1β and tumor necrosis factor α (TNFα). We examined the cytokine mRNA expression of PBMC following treatment with IL-2 in vitro and in vivo by a quantitative method using the reverse transcription/polymerase chain reaction (RT-PCR). After stimulating PBMC with IL-2 in vitro, peak levels of IL-1α mRNA were reached between 3 h and 12 h, and thereafter declined. The IL-1β expression increased, with levels peaking at 1–6 h and, had decreased by 96 h. The expression of TNFα was elevated both 1–3 h and 24–48 h after stimulation. The peak levels of IL-1α and -1β mRNA and the early elevation of TNFα mRNA mainly accounted for the cytokine mRNA expression in adherent cells; however, the late induction of TNFα mRNA was observed in nonadherent cells. In patients with advanced carcinoma, the IL-1α and -1β mRNA expression were elevated after IL-2 treatment for 5 consecutive days, while the expression of TNFα mRNA also increased. These results indicate that the quantitative RT-PCR method appears to be useful for analyzing the cytokine mRNA expression of PBMC after treatment with IL-2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050390
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  • 6
    Electronic Resource
    Electronic Resource
    Apoptosis in antibody-dependent monocyte-mediated cytotoxicity with monoclonal antibody 17-1A against human colorectal carcinoma cells: enhancement with interferon γ (1996)
    Springer
    Cancer immunology immunotherapy 43 (1996), S. 220-225 
    Details
    ISSN: 1432-0851
    Keywords: Key words Apoptosis ; Antibody-dependent cell-mediated cytotoxicity ; Monocyte ; 17-1A ; Interferon γ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Antibody-dependent cell-mediated cytotoxicity (ADCC) has been considered to be one of the main effector mechanisms by which unconjugated monoclonal antibody (mAb) 17-1A can exert an antitumor effect in vivo. Since the apoptotic pathway as well as the necrotic pathway have been shown to be utilized in various cytotoxic effector mechanisms, we investigated the role of apoptosis in ADCC mediated by monocytes (ADMC) using mAb 17-1A as an antibody and the human colorectal carcinoma cell line, COLO205, as target cells in vitro. The implications of the apoptosis during ADMC was demonstrated by means of both a DNA fragmentation assay and a TdT-mediated dUTP-biotin nick end labeling (TUNEL) assay. Furthermore, interferon γ (IFNγ) was also found to enhance the induction of apoptosis significantly. The addition of superoxide dismutase did not reduce the level of the apoptosis, although superoxide anion (O2 –) was observed to be produced. However, the release of tumor necrosis factor α (TNFα) was significantly enhanced during ADMC, while, in addition, apoptosis was significantly inhibited by the addition of anti-TNFα antibody. These findings indicated that apoptosis might be implicated in ADMC with mAb 17-1A, which was augmented by IFNγ, while, in addition, TNFα may also be one of the major mediators of apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050325
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  • 7
    Electronic Resource
    Electronic Resource
    Augmentation of the generation of cell-mediated cytotoxicity in culture by mitomycin C (1987)
    Springer
    Cancer immunology immunotherapy 24 (1987), S. 259-262 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of mitomycin C (MMC) on the generation of cell-mediated cytotoxicity in primary stimulation culture of human peripheral blood mononuclear cells (PBM) with the B lymphoblastoid Raji cell line were assessed. The cell-mediated cytotoxicity induced in culture was significantly augmented when MMC was added to cultures on day −1 to day 3 for 24 h at concentrations of 2.5×10−2 μg/ml and 2.5×10−3 μg/ml. To identify the cell populations affected by MMC, PBM were separated by adherence to plastic after treatment with MMC for 24 h (day −1). The two populations were recombined with untreated separated cells and stimulated with antigen. The ability to develop an augmented cell-mediated cytotoxicity was associated with the adherent cell fraction of MMC-treated PBM. Therefore, the ability of MMC-treated adherent cells to produce interleukin 1 (IL 1) was examined. Significantly higher levels of IL 1 were produced by treated cells as compared to untreated adherent cells. The results appear to indicate that the selective effects of MMC on the adherent cell fraction, especially the modification of IL 1 production, may be involved in the mechanisms of MMC-induced augmented cell-mediated cytotoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205640
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  • 8
    Electronic Resource
    Electronic Resource
    Augmentation of the generation of lymphokine-activated killer cells after a single dose of mitomycin C in cancer patients (1989)
    Springer
    Cancer immunology immunotherapy 29 (1989), S. 237-241 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of mitomycin C administration on the generation of cytotoxic cells, induced by in vitro activation of peripheral blood mononuclear cells (PBM) with interleukin-2, was studied in patients with various carcinomas. The ability of PBM to generate lymphokine-activated killer (LAK) cell activity against Raji cell targets was significantly augmented 5 and 7 days after a single intravenous dose of 12 mg/m2 mitomycin C, when compared to that of PBM obtained before mitomycin C injection. Further, LAK cell activity against autologous tumor cells was also significantly increased after the drug administration. The distribution of lymphocyte subsets exhibited a significant increase in the percentage of CD3+ cells after injection, with the elevation of the CD4/CD8 ratio. Furthermore, the proportion of the CD4+ Leu8+ subpopulation, which identifies inducers of suppression, was significantly reduced. Thus, the decrease in the proportion of suppressor-inducer subsets of PBM might be at least partially, responsible for the augmented generation of LAK cells after mitomycin C administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199210
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  • 9
    Electronic Resource
    Electronic Resource
    Neuroleptic malignant syndrome occurring after an emergency operation for traumatic duodenal perforation: Report of a case (1994)
    Springer
    Surgery today 24 (1994), S. 276-279 
    Details
    ISSN: 1436-2813
    Keywords: neuroleptic malignant syndrome ; postoperative complication ; differential diagnosis ; traumatic duodenal perforation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neuroleptic malignant syndrome (NMS) is a potentially fatal complication which may develop in psychiatric patients taking neuroleptic drugs. We report herein the successful treatment of a 33-year-old schizophrenic man, prescribed neuroleptic drugs, who underwent an emergency operation for traumatic duodenal perforation with a retroperitoneal infection. Five days after the operation, he began to demonstrate clinical features consistent with NMS such as high fever, abnormalities in vital signs, leukocytosis, and an elevated serum level of creatine phosphokinase; however, these findings were first presumed to be secondary to either the preexisting tissue injuries or to postoperative complications. A definite diagnosis of NMS was thus delayed until muscle rigidity and autonomic instability became evident. After a tentative diagnosis of NMS had been made, sodium dantrolene, a drug used specifically for the treatment of NMS, was administered and the patient's condition remarkably improved. Since NMS can be induced by either interrupting the course of neuroleptic drugs or by the additional administration of sedative drugs, and since its mortality rate is high if prompt and appropriate treatment is not carried out, surgeons should bear in mind the possibility of NMS developing postoperatively in psychiatric patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032902
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  • 10
    Electronic Resource
    Electronic Resource
    Depression of the generation of cell-mediated cytotoxicity after surgery (1983)
    Springer
    Surgery today 13 (1983), S. 191-195 
    Details
    ISSN: 1436-2813
    Keywords: depression of cell-mediated cytotoxicity ; operative stress ; malignant lesions ; benign lesions ; Raji cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of surgery on generation of cell-mediated cytotoxicity in mixed cell cultures were studied in patients with various carcinomas, and the results were compared to those in patients with benign lesion. Peripheral mononuclear cells were cultured with the B-lymphoblastoid cell Raji in a mixed culture and the induced cytotoxicity was measured by51Cr release assay. In 15 patients with various carcinomas, the capacity of peripheral mononuclear cells to generate cytotoxic cells was significantly depressed 1, 3 and 6 days after surgery, as compared to findings before surgery. Preoperative levels were reverted to by the 8th postoperative day. In 8 patients with benign lesion, significant decreases in cytotoxic cell activity were observed 3 and 6 days after operation and, on the 8th postoperative day, there was a significant increase in the generated cytotoxicity, as compared to the preoperative activity. Thus, postoperative depression of the generation of cell-mediated cytotoxicity may affect the host-tumor relationship in patients with carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469475
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