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  • 1
    Electronic Resource
    Electronic Resource
    Capping of the dental pulp mechanically exposed to the oral microflora – a 5 week observation of wound healing in the monkey (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 11 (1982), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The healing capacity of mechanically exposed and bacterially contaminated dental pulps was assessed in monkeys after capping with 2 commercial Ca(OH)2 containing compounds. One hundred eighty teeth in 7 monkeys were employed, 45 as untreated controls and 135 as treated exposures. Class V buccal cavity preparations resulting in pulpal exposure were prepared, left open to the oral cavity for 0, 1, 24 h or 7 days and employed as controls, or debrided, capped, restored with amalgam and left undisturbed for 5 weeks as treated exposures. Zero and 1 h untreated exposures presented damage from the mechanical trauma only, whereas 24 h and 7 day pulp wounds exhibited pronounced infiltrations of polymorphonuclear and mononuclear leukocytes. In addition, the 7 day exposures demonstrated several teeth with partial and total necrosis. Treated 0, 1 and 24 h exposures demonstrated wound healing, minimal pulp tissue inflammation, reorganization of soft tissue and formation of new hard tissue at the exposure site in 86 of 99 teeth. Treated 7 day exposures healed less frequently, showing signs of dentin bridging in 15 of 27 teeth. This study indicated that mechanically exposed and orally contaminated dental pulps in monkeys have a high capacity to resolve inflammation and initiate healing with new dentin formation at the exposure site when treated as described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1982.tb00173.x
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  • 2
    Electronic Resource
    Electronic Resource
    Neuroregulation of protein synthesis in odontoblasts of the first molar of the rat after wounding (1987)
    Springer
    Cell & tissue research 248 (1987), S. 119-123 
    Details
    ISSN: 1432-0878
    Keywords: Odontoblasts ; Protein synthesis ; Denervation ; Neural regulation ; Wound healing ; Autoradiography ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Odontoblasts respond to occlusal trauma by increased elaboration of a matrix which is subsequently calcified to form reparative dentin. The purpose of the present study was to analyze quantitatively and compare the ability of odontoblasts to synthesize collagen after wounding in rats with an intact innervation (baseline) and in rats with sensory (inferior alveolar nerve, IAN) and/or sympathetic (superior cervical ganglion, SCG) surgical denervation. Surgery was performed 7 days prior to wounding. All rats had 1 mm of enamel and dentin removed from the occlusal surface of the first mandibular molar (resected side) with the contralateral tooth serving as a control. Rats were killed 1 h after injection with3H-proline on days 0, 5, 10 or 15 after wounding, and mandibles were removed and processed for autoradiography. Grain counts were performed over odontoblasts throughout the pulp horns for each time period and for control and experimental molars in intact (baseline) and denervated groups. When compared to the control baseline, the experimental baseline data showed increased3-proline uptake throughout the study with a peak at 5 days. When compared to the baseline data, IAN and SCG results demonstrated a delay or attenuation of the protein synthetic response. The results indicate that the sensory and sympathetic neural components may regulate odontoblastic response to wounding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01239971
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  • 3
    Electronic Resource
    Electronic Resource
    The fine structure of intercellular substances and rounded cells in the incisor pulp of the guinea pigThis investigation was supported in part by a grant from the United States Public Health Service (D-1620) (1965)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 151 (1965), S. 41-57 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The fine structure of intercellular substances and rounded cells of the incisor dental pulp of guinea pigs is described. The extracellular fibrils are of two kinds; collagen with typical cross-striations, varying from 400-700 Å in diameter, and fine fibrils of 100-120 Å in diameter. In cross section the latter fibrils appeared to be composed of three or four smaller subunits of less than 50 Å in diameter. The collagen fibril in the dental pulp appear singly or in small bundles of about a dozen or more fibrils. The fine fibrils are often aggregated along the cell surface.The ground substances are finely granular to fibrillar and show localized clumping which is related to fibrillar elements. The ground substances form an incomplete covering of 200 Å or more in thickness surrounuding collagen fibrils. When the collagen fibrils make a bundle, the sheath of grouund substances around one fibril becomes fused with that of adjacent fibrils.Rounded cells including macrophages, lymphocytes and eosinophils are present in the pulp. The fine structure of these cells is similar to that found in the same types of cells previously observed in other organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091510105
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  • 4
    Electronic Resource
    Electronic Resource
    Karl Ernest Mason, 1900-1978 (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 198 (1980), S. 1-12 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091980102
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructure of terminal pulpal blood vessels in mouse molarsThis project was supported by USPHS Research Grant DE 01604 from the National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland. (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 179 (1974), S. 527-541 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The purpose of this investigation was to study the fine structure of pulpal capillaries located in the odontoblastic layer and immediate subjacent zone. The observations were from first molars of white mice sacrificed at five day intervals from 25-90 days. Both capillaries and small vessels with an incomplete smooth muscular coating appeared in the zone subjacent to the odontoblastic layer from 25-60 days. At the same time, capillaries which exhibited intracellular fenestrations in the endothelial wall were located within the odontoblastic layer.From 50-90 days, the capillaries among odontoblasts, especially at the pulpal horns, appeared close to the predentinal surface, and an isolated capillary appeared to extend into predentin and run parallel to the outer surface of the odontoblastic layer for a short distance. At these ages, the capillaries subjacent to the odontoblastic layer also exhibited fenestrations along the thin endothelial walls similar to those observed at earlier ages in capillaries among odontoblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091790413
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  • 6
    Electronic Resource
    Electronic Resource
    Presence and location of adrenergic nerve endings in the dental pulps of mouse molars (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 198 (1980), S. 59-71 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In all, 30 adult (45-day-old) Swiss Webster mice were used for light and electron microscopic examination of the presence, number, and location of adrenergic endings in the first molar teeth. Prior to sacrifice, 10 animals received i.p. injections at 8, 6, 4, and 2 hours of 0.5 cc of 20 mg/kg solution of 5-hydroxydopamine (5-OH-DA) as a label for adrenergic endings. The animals were then anesthetized, perfused with Karnovsky's fixative, and the teeth were postfixed in Osmic acid, decalcified, embedded in methacrylate, and serial-sectioned. The sections were surveyed by light microscopy, and the number and location of nerve endings containing the reduced 5-OH-DA were recorded. Ten control mice were injected with the vehicle solution and prepared in the same manner. A third series of mice were given a single injection of 5-OH-DA, sacrificed, and prepared for ultrastructural study. The molar pulps were divided into four areas to facilitate examination: pulp horns, coronal pulp, bifurcation area, and root pulp. These four areas were further divided into three zones: odontogenic, vascular-related, and nonvascular-associated. The location and number of endings were evaluated, and an average of approximately 70 endings containing the 5-OH-DA were found in each tooth using light microscopy. These represented 35.5 ± 5.2 in the pulp horns; 26.1 ± 2.4 in the central coronal; 5.4 ± 0.7 in the bifurcation, and 5.6 ± 0.9 in the root pulp per tooth. Vascular related endings were found in greatest number, the odontogenic zone next, and free endings least. Verification of location of 5-OH-DA by ultrastructural analysis revealed the false transmitter in vesiculated endings in the four areas and zones of the pulp.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091980105
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  • 7
    Electronic Resource
    Electronic Resource
    The ultrastructure of capillaries and arterioles of the hamster dental pulpThis investigation was supported by U.S.P.H.S. research grant D-1620 from the National Institute of Dental Research, National Institutes of Health. (1963)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 145 (1963), S. 549-571 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The ultrastructure of capillaries and arterioles of the hamster dental pulp has been studied. Pieces of the incisor pulp were fixed in 1% OsO4 buffered with 0.14 M veronal acetate, embedded in epoxy resin and studied in an electron microscope. The basic cytoplasmic organization of endothelial cells confirmed observations on blood vessels of other organs made by previous investigators. A large number of intracytoplasmic fibrils were found in many endothelial cells, and their presence was discussed in relation to earlier reports on the contractility of endothelial cells. Previous observations on the structural details of the intercellular region of the endothelium were confirmed and elaborated upon. The manner in which the cytoplasmic flaps of adjoining cells were oriented indicated that, if the integrity of the capillary wall was maintained, only cells with capacity for ameboid movement could creep through the region. Thus they were thought to play a role as an effective barrier against the passage of red blood cells. Numerous micropinocytosis and pinocytosis vesicles were found in association with plasma membranes. The significance of their structure in the transport of materials across the capillary wall is discussed. The fine structure of the pericyte resembled that of the fibroblast. Portions of plasma membranes of adjacent smooth muscle cells in the media of arterioles were brought together closely and resembled attachment zones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091450408
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  • 8
    Electronic Resource
    Electronic Resource
    The fine structure of differentiating fibroblasts in the incisor pulp of the guinea pigSupported in part by grant D-1620 from The United States Public Health Service. (1965)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 153 (1965), S. 187-209 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The differentiation of the fibroblast was followed in the dental pulp of continuously growing incisors of the guinea pig. Based on the ultrastructure, the processes of differentiation of the fibroblasts might be conveniently broken into three stages; Stage I - period of early differentiation, Stage II - period of maturation and functioning, and Stage III - period of regression.During Stage I the cell had structural characteristics shared by other less differentiated cells. The endoplasmic reticulum was poorly developed, showing vesicular to tubular profiles. The ribosomes were abundant but were mostly distributed in free form. Mitochondria were small and had irregular interiors.Stage II was characterized by a striking development of the rough-surfaced endoplasmic reticulum, which appeared in various shapes and sizes. The Golgi complex was enlarged, and contained some fibriller materials in dilated portions of its membraneous elements. Other features described in the cytoplasm of fibroblasts from other sources were confirmed.Stage III was characterized by the decrease in size and number of various cytoplasmic constituents and was considered to represent cells in the state of regression.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091530208
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  • 9
    Electronic Resource
    Electronic Resource
    The ultrastructure of intradental nerves in developing mouse molarsThis project was supported by USPHS Research grant DE 01604 from the National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland. (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 175 (1973), S. 585-605 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The purpose of this investigation was to study the nerves in mouse molar teeth during their development to observe their distribution and their relationship to the odontoblast and its process. The specimens were first assessed by light microscopy using silver staining techniques. It was found that by nine days after birth, major nerves appeared in the pulp organ and extended to the basal region of the odontoblasts. At 15 days, a subodontoblastic neural plexus had developed, and by 25 days, isolated nerves penetrated into the predentin of the pulpal horns. From 25-70 days, a highly organized subodontoblastic plexus was apparent with branches extending into the odontoblastic layer, predentin and inner dentin.Ultrastructural study revealed small, nonmyelinated nerves at the basal region of the odontoblasts by nine days. Both myelinated and small, nonmyelinated nerves appeared in the subodontoblastic plexus. Small nerves closely associated with the odontoblastic process were found within the predentinal tubules by 25 days. These processes contained occasional mitochondria, numerous microvesicles and small dark granules. From 35-50 days of age, similar nerves which exhibited alternate constrictions and dilations along their lengths were found in the tubules of circumpulpal dentin. By 60 days, both Schwann cell covered and naked axons appeared among the odontoblasts, and by 70 days Schwann cell covered axons appeared in predentin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091750307
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  • 10
    Electronic Resource
    Electronic Resource
    Denervation-induced changes in cell proliferation in the rat molar after wounding (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 214 (1986), S. 348-352 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The dental pulp has the capacity to initiate and maintain repair after trauma. The purpose of the present study was to quantitatively analyze the role of the peripheral nervous system in regulation of pulpal cell proliferation in response to wounding. Six groups often rats were used in these studies. There was one baseline group (wounded, but innervation intact) and five resection groups. The resection groups included rats with unilateral superior cervical ganglionectomy (SCG), unilateral inferior alveolar nerve resection (IAN), unilateral chorda tympani (CT) resection, IAN + SCG, or a complete unilateral nerve resection (IAN + SCG + CT). One millimeter of enamel and dentin was removed from the first mandibular molar on the experimental (resected) side. Therefore, each rat had an experimental and control molar. Rats were killed at various intervals from day 0 to day 15 after wounding and received 0.5 μCi/g b.wt. 3H-thymidine 1 hour before death. For the baseline (innervation intact) data a peak in 3H-thymidine incorporation occurred at 5 days after wounding. In the resected groups, there was a general increase in the number of labeled cells at the zero time point, and a suppression of the 5-day peak with a delay in the proliferative response to wounding. The SCG + IAN-resected group maintained the lowest number of labeled cells throughout the entire experimental period compared to the experimental baseline data and the two controls. At the initial and termination points the SCG + IAN-resected groups demonstrated the highest number of labeled cells. The baseline data indicate that the maximal response to wounding occurs at day 5. Denervation results in a delay of the cell proliferative response to wounding with the most dramatic delay occurring in the IAN + SCG-resection group. The results indicate that the autonomic and sensory components of the peripheral nervous system may interact in regulating the proliferative response of pulpal cells to wounding.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092140403
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