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  • 1
    Electronic Resource
    Electronic Resource
    Evolution and the Tertiary Structure of Proteins (1984)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 13 (1984), S. 453-492 
    Details
    ISSN: 0084-6589
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bb.13.060184.002321
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  • 2
    Electronic Resource
    Electronic Resource
    The mechanism of iron uptake by transferrins: the structure of an 18 kDa NII-domain fragment from duck ovotransferrin at 2.3 Å resolution (1993)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 49 (1993), S. 292-304 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The molecular structure of an iron-containing 18 kDa fragment of duck ovotransferrin, obtained by proteolysis of the intact protein, has been elucidated by protein crystallographic techniques at 2.3 Å resolution. This structure supports a mechanism of iron uptake in the intact protein whereby the binding of the synergistic (bi)carbonate anion is followed by binding of the metal with the lobe in the open configuration. These stages are then followed by domain closure in which the aspartic acid residue plays a further key role, by forming an interdomain hydrogen-bond interaction in addition to serving as a ligand to the iron. This essential dual role is highlighted by model building studies on the C-terminal lobe of a known human variant. In this variant a mutation of a glycine by an arginine residue enables the aspartic acid to form an ion pair and reduce its effectiveness for both metal binding and domain closure. The X-ray structure of the 18 kDa fragment strongly suggests that the histidine residue present at the iron binding site of the intact protein and arising from the second interdomain connecting strand has been removed during the preparative proteolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444992012101
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  • 3
    Electronic Resource
    Electronic Resource
    On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 916 (1987), S. 220-226 
    Details
    ISSN: 0167-4838
    Keywords: (Drosophila) ; (Human) ; Epidermal growth factor ; Hormone receptor ; Insulin receptor ; Secondary structure
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(87)90112-9
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  • 4
    Electronic Resource
    Electronic Resource
    Dividend clienteles and the information content of dividend changes
    Amsterdam : Elsevier
    Journal of Financial Economics 26 (1990), S. 193-219 
    Details
    ISSN: 0304-405X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-405X(90)90003-I
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  • 5
    Electronic Resource
    Electronic Resource
    Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome (1999)
    Springer
    Intensive care medicine 25 (1999), S. 1259-1266 
    Details
    ISSN: 1432-1238
    Keywords: Key words ARDS ; Acute lung injury ; Endothelial injury markers ; von Willebrand factor levels ; TFPI levels ; Thrombomodulin levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To determine if the plasma levels of three endothelial-specific proteins, von Willebrand factor (vWF), tissue factor pathway inhibitor (TFPI) and thrombomodulin (TM) may be useful in predicting the development of acute respiratory distress syndrome (ARDS).¶Design: Blood samples were obtained from normal healthy volunteers and on the first day from patients at risk for ARDS and those with ARDS. Daily sequential measurements of vWF and TFPI were performed in two patients.¶Setting: Normal subjects were employees at Saint Louis University Hospital, St. Louis, Missouri. Patients at risk and those with ARDS were patients admitted to the medical and surgical floors and the intensive care units at St. Louis University Hospital.¶Patients and participants: Plasma levels of vWF, TFPI and TM were measured in 27 normals, and on day 1 in 15 patients at risk for ARDS and 18 patients with ARDS from different etiologic factors.¶Measurements and results: Plasma levels of vWF were significantly elevated in the at-risk (p 〈 0.01) and ARDS group (p 〈 0.001) as compared to normals but did not differ significantly between the two groups (p 〉 0.05). Plasma levels of TFPI were not significantly different between the normal and the at-risk group (p 〉 0.05); however, they were significantly elevated in ARDS as compared with at-risk and normal groups (p 〈 0.001). Levels of TM were significantly increased in the at-risk group as compared to normals (p 〈 0.01) but were not significantly different from the ARDS group (p 〉 0.05). Eight patients at risk progressed to develop ARDS. A vWF level of 〉 300 % in patients at risk was 62 % sensitive and 71 % specific for predicting the development of ARDS with a positive predictive value of only 34 %. TFPI levels were normal in 7 of the 8 patients who developed ARDS. A TM level of 〉 100 ng/ml in patients at risk was 50 % sensitive and 57 % specific with a positive predictive value of merely 8 % for development of ARDS. There was no significant difference in the mean plasma levels of the three proteins on day 1 in patients at risk who developed ARDS as compared with those who did not develop ARDS. There was also no difference in mean plasma levels of the three proteins in patients with ARDS from sepsis as compared with ARDS from other etiologies. Plasma levels of vWF and TFPI correlated significantly.¶Conclusion: Plasma levels of vWF, TFPI and TM did not appear to serve as useful markers for predicting ARDS in patients at risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051054
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  • 6
    Electronic Resource
    Electronic Resource
    Studies on the development of high-protein biscuits from composite flours (1993)
    Springer
    Plant foods for human nutrition 43 (1993), S. 181-189 
    Details
    ISSN: 1573-9104
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Composite flours prepared from wheat, greengram, bengalgram and blackgram flours were studied for the preparation of biscuits. Protein content of biscuits increased as the level of the pulse flours increased. Wheat flour containing bengalgram and blackgram flours adversely affected the top grain, texture and colour of biscuits. Biscuits made with higher levels of bengalgram (more than 15%) were tough and difficult to break and required higher compression force. Addition of greengram flour did not significantly affect top grain, texture and colour of biscuits. The biscuits made from 15% greengram supplemented wheat flour scored the highest for flavour characteristics. Thickness, diameter and spread ratio of biscuits containing different levels of pulse flours were significantly different from control sample. Sensory evaluation scores showed that acceptable biscuits can be prepared from wheat flour supplemented with these pulse flours at a level of 15 percent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01087922
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