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  • 1
    Electronic Resource
    Electronic Resource
    The human locus coeruleus complex: an immunohistochemical and three dimensional reconstruction study (1989)
    Springer
    Experimental brain research 77 (1989), S. 257-270 
    Details
    ISSN: 1432-1106
    Keywords: Tyrosine hydroxylase ; Nucleus subcoeruleus ; Quantitative analysis ; Pontine tegmentum ; Morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The CA (catecholamine/catecholaminergic) cell populations of the locus coeruleus (LC) and subcoeruleus (SubC) were studied using serial sections of the human brainstem immunostained with an antibody against tyrosine hydroxylase. The tyrosine hydroxylase-immunoreactive (TH-IR) neurons were plotted in a computer reconstruction system and their number and soma size determined. Serial section computer analysis was then used to create a three dimensional reconstruction of the LC complex. The number of cells containing neuromelanin pigment was also determined and compared with the number of TH-IR cells. In our sample there were 53,900 TH-IR cells in the LC and a further 6260 cells in the SubC. These numbers were very similar to our estimates of the number of cells containing neuromelanin pigment and we concluded that virtually all of these cells were also tyrosine hydroxylase positive. The average soma size of the TH-IR cells of the LC was 37 μm and in the SubC 34 μm. In addition to these quantitative observations the morphology of the TH-IR and the Nissl stained cells is described in some detail. We also compared the groups of immunoreactive cells in the human pons with the noradrenergic groups A5–A7 described in the rat. Although in the human these groups are contiguous, A5 is not part of the LC complex. However we did find that the A7 group is equivalent to the rostroventral part of SubC while the remainder of SubC is formed by ventral A6.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274983
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The human locus coeruleus complex: an immunohistochemical and three dimensional reconstruction study (1990)
    Springer
    Experimental brain research 79 (1990), S. 664-664 
    Details
    ISSN: 1432-1106
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229335
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chronic alcoholism in the absence of Wernicke-Korsakoff syndrome and cirrhosis does not result in the loss of serotonergic neurons from the median raphe nucleus (1996)
    Springer
    Metabolic brain disease 11 (1996), S. 217-227 
    Details
    ISSN: 1573-7365
    Keywords: Alcohol ; serotonin ; neuropathology ; median raphe nucleus ; Wernicke-Korsakoff ; cirrhosis ; thiamine deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous studies have identified alcohol, thiamine deficiency and liver disease as contributing to the neuropathology of alcohol-related brain damage. In order to examine the effects of alcohol toxicity and thiamine deficiency on serotonergic neurons in the median raphe nucleus (MnR), alcoholic and previously published Wernicke-Korsakoff syndrome (WKS) cases without liver disease, were compared with age-matched non-alcoholic controls. While there was no difference between the estimated number of serotonergic neurons in either controls or alcoholics without WKS (means of 63,010±8,900 and 59,560±8,010 respectively), a substantial loss of serotonergic neurons was previously found in WKS cases (mean of 19,050±13,140). Further analysis revealed a significant difference in the maximum daily alcohol consumption between these groups. However, analysis of covariance showed that the number or serotonergic neurons in the MnR did not correlate with the amount of alcohol consumed. Therefore, our results suggest that cell loss in the MnR can be attributed to thiamine deficiency rather than alcoholper se.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02237959
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    Paper (German National Licenses)
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