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  • 1
    Digitale Medien
    Digitale Medien
    A 1.5–4 K detachable cold-sample transfer system: Application to inertially confined fusion with spin-polarized hydrogen fuels (1991)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 62 (1991), S. 2729-2737 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: A compact cold-transfer apparatus for engaging and retrieving samples at liquid-helium temperatures (1.5–4 K), maintaining the samples at such temperatures for periods of hours, and subsequently inserting them in diverse apparatuses followed by disengagement, is described. The properties of several thermal radiation-insulating shrouds, necessary for very low sample temperatures, are presented. The immediate intended application is transportable target shells containing highly spin-polarized deuterons in solid HD or D2 for inertially confined fusion experiments. The system is also valuable for unpolarized high-density fusion fuels, as well as for other applications which are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1142206
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  • 2
    Digitale Medien
    Digitale Medien
    Differentiating keratoacanthoma from squamous cell carcinoma by the use of apoptotic and cell adhesion markers (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 47 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aims : Keratoacanthomas (KA) are well-differentiated squamoproliferative skin lesions that grow rapidly and regress spontaneously. In contrast, squamous cell carcinomas (SCC) can have variable differentiation, inexorably progress and on occasion metastasize. Distinguishing between KA and SCC using haematoxylin and eosin-stained sections from an initial biopsy can often be difficult. There is also some debate as to whether KA is simply a variety of well-differentiated SCC or a distinct entity.Methods and results : Initial biopsy sections from 25 cases of SCC and 20 of KA were labelled with markers for both the initiation (the cytolytic receptor P2X7) and end-stage (terminal deoxynucleotidyl transferase biotin–dUTP nick end labelling) of apoptosis, telomerase-associated protein (TP1) and the cell adhesion protein E-cadherin. As this was a retrospective study, the clinical outcome of each case was known. This resulted in a unique labelling pattern of each marker for SCC and KA, allowing a differential diagnosis between the two conditions. The simplest marker to use for this purpose was anti-P2X7. Sections from five cases that were initially very difficult to diagnose were correctly identified as SCC using this method.Conclusions : These results support the view that KA has a different pathogenesis and biochemistry from that of SCC, and is a distinct entity. Anti-P2X7 labelling, using routine immunohistochemical techniques, provides a method for differentially diagnosing these conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02155.x
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  • 3
    Digitale Medien
    Digitale Medien
    Early prostate cancer detected using expression of non-functional cytolytic P2X7 receptors (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 44 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aims:  To detect early prostate cancer reliably by monitoring the expression of non-functional P2X7 cytolytic purinergic receptors.Methods and results:  P2X7 receptors were absent from normal prostate epithelium obtained from post mortem tissue and tissue from cases of transurethral resection collected from young men (n = 23) who were confirmed to be free of cancer at later procedures 5–10 years after collection of the original samples. However, P2X7 was present in every case of 116 confirmed prostate cancers regardless of Gleason grade or patient age. P2X7 was present in apparently normal epithelial cells in acini well outside the tumour margins, but appeared in a distinct stage-specific manner commencing with the nucleus, progressing to the cytoplasm and collecting finally on the apical membrane of the epithelial cells in morphologically distinct cancer. The pattern of P2X7 receptor localization in the epithelial cells was recorded in earlier biopsies obtained from the same patient cohort. One hundred and fourteen of 116 prostates stained positively for P2X7 at the earliest biopsy, though generally with a less advanced pattern of distribution.Conclusions:  The appearance of P2X7 receptors in normal prostate tissue adjacent to prostate tumours makes direct tumour biopsy less critical for positive cancer diagnosis and enables cancer progression to be monitored.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.0309-0167.2004.01798.x
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  • 4
    Digitale Medien
    Digitale Medien
    Sarcomere shortening and tension development during ‘isometric’ tetanus of muscle (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1584-1585 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Laser diffraction and tension measurements from frog muscle during isometric tetanus reveal that the sarcomeres contract more rapidly than tension develops.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01953207
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  • 5
    Digitale Medien
    Digitale Medien
    Weight-/height-related bone mineral density is not reduced after renal transplantation (1998)
    Springer
    Pediatric nephrology 12 (1998), S. 343-348 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Key words: Renal transplantation ; Bone mineral density ; Growth ; Corticosteroids
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Growth retardation is a frequent finding in patients after renal transplantation (Tx). Areal bone mineral density (BMD) in these patients has usually been reported to be low for age. We investigated the possible influence of height and weight retardation on the measurement of BMD in lumbar spine (BMDL2-4) and total body (BMDbody) using dual-energy X-ray absorptiometry in 44 (13 female) pediatric Tx patients with a median age of 13.1 (range 3.3–23.1) years. Patients were studied at 2.9 (range 1–10) years after Tx. Median body height in female and male patients was –2.10 (–3.6 to -0.3) and –2.35 (–5.3 to +1.0) standard deviation score (SDS), respectively. BMD expressed as grams per square centimeter bone area according to age was below the 5th percentile in 10 of 44 patients, but only 1 patient had low values for BMDL2-4, and none for BMDbody, when the data were corrected for height or weight. BMDbody was closely correlated with height, weight, and body surface area (r=0.88), whereas the correlation for BMDL2-4 was less (r=0.76). In 6 patients who achieved final height, height SDS was –2.27 (–4.3–0.4). Z-scores for BMDbody related to age, height, and weight were –1.0 (–2.6 to –2.3), 1.25 (0.1–3.4), and 0.81 (0.0–2.4), respectively. There was no age-dependent change when areal BMD values (g/cm2) were corrected for vertebral size to obtain bone volumetric density (BMDvol, g/cm3). Independent of height, cumulative methylprednisolone dose correlated negatively with BMDL2-4 only in patients who had received a total dose of more than 6 g/m2 of the drug (r =–0.54, P = 0.045). In conclusion, BMD in pediatric patients after Tx is no longer diminished when the data are corrected for height or weight rather than age, or when the data are expressed as bone volumetric density.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004670050464
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  • 6
    Digitale Medien
    Digitale Medien
    Actin dynamics studied by solid-state NMR spectroscopy (1991)
    Springer
    European biophysics journal 19 (1991), S. 147-155 
    Details
    ISSN: 1432-1017
    Schlagwort(e): Actin ; Solid-state NMR spectroscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Physik
    Notizen: Abstract Solid-state nuclear magnetic resonance spectroscopy was used to study the motion of 2H and 19F probes attached to the skeletal muscle actin residues Cys-10, Lys-61 and Cys-374. The probe resonances were observed in dried and hydrated G-actin, F-actin and F-actin-myosin subfragment-1 complexes. Restricted motion was exhibited by 19F probes attached to Cys-10 and Cys-374 on actin. The dynamics of probes attached to dry cysteine powder or F-actin were very similar and the binding of myosin had little effect indicating that the local probe environment imposes the major influence on motion in the solid state. Correlation times determined for the solid state probes indicated that they were undergoing some rapid internal motion in both G-actin and F-actin such as domain twisting. The probe size influenced the motion in G-actin and appeared to sense monomer rotation but not in F-actin where segmental mobility and intramonomer co-ordination appeared to dominate.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00185455
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  • 7
    Digitale Medien
    Digitale Medien
    Development of P2X receptor clusters on smooth muscle cells in relation to nerve varicosities in the rat urinary bladder (1999)
    Springer
    Journal of neurocytology 28 (1999), S. 4-16 
    Details
    ISSN: 1573-7381
    Schlagwort(e): Development ; purinergic ; varicosities ; smooth muscle
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Postnatal development of the distribution of different isoforms of purinergic (P2X) receptors on smooth muscle cells in relation to the development of the innervation of the cells by nerve varicosities in the rat urinary bladder has been determined with immunofluorescence and confocal microscopy. Antibodies against the extracellular domains of the P2X1 to P2X6 receptors were used to detect the receptors in the bladder. Several other antibodies were used to identify sympathetic varicosities and Schwann cells. At one day postnatal (D1) there were few strings of varicosities denoting isolated axons, with most axons confined to large nerve trunks. Small size clusters of P2X1 to P2X6 receptor subtypes (about 0.4 µm diameter) were observed in the muscle which were independent of each other, and sometimes juxtaposed to the rare isolated varicosity strings. At D4 large numbers of strings of varicosities could be discerned throughout the detrusor. Most of these clouds of small P2X1 to P2X6 receptor clusters in their immediate vicinity. Some of these were colocalised with the varicosities, which were of parasympathetic origin as they failed to counter-stain with antibodies to tyrosine hydroxylase. Up to D14 there was a gradual coalescence of many of the isolated P2X1–6 small receptor clusters so that they became colocalised, often at varicosities. Most of the varicosities in isolated strings possessed receptor clusters at this time. By D21 it was rare to find varicosity strings in the detrusor that were not either in close juxtaposition with P2X small receptor clusters or possessing such clusters in colocalisation. However, large numbers of small P2X receptor clusters, many of which consisted of a mixture of isoforms, could be found spatially unrelated to nerve varicosities throughout the detrusor muscle. In the adult, single axons were either coextensive with one or more isoforms of P2X receptor clusters or these were immediately juxtaposed to the axons so that is was rare to find a varicosity that did not possess a receptor cluster. However, different combinations of colocalised P2X receptor isoforms could still be discerned in small clusters unrelated to varicosities. These observations are discussed in relation to the mechanism of formation of the receptor clusters and their migration beneath parasympathetic varicosities during development.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1007043132537
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  • 8
    Digitale Medien
    Digitale Medien
    P2X (purinergic) receptor redistribution in rabbit aorta following injury to endothelial cells and cholesterol feeding (2000)
    Springer
    Journal of neurocytology 29 (2000), S. 623-631 
    Details
    ISSN: 1573-7381
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The redistribution of purinergic P2X receptor subunits (P2X1 to P2X7) within the rabbit aorta wall three weeks after endothelial balloon injury/cholesterol feeding was examined. P2X1 receptor cluster density was elevated in the media following balloon injury/cholesterol feeding by about 30% and these clusters appeared on smooth muscle cells throughout the greatly expanded neointima but they did not change significantly on the endothelial cells following balloon injury. P2X4 clusters were found in high density throughout the media and in very high density in the enlarged neointima following balloon injury, particularly on the endothelial cells where the density increased about 10-fold after balloon injury. P2X5 clusters were found in high density in the media of normal aorta but with little change following balloon injury. P2X3, P2X6 and P2X7 cluster density was low in normal aorta and remained unchanged following balloon injury. All receptor subunits were found on endothelial cells. It is suggested that the release of ATP from damaged endothelial cells and from smooth muscle cells sufficient to activate P2X4 receptors may contribute to neointimal proliferation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1010828302936
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