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  • 1
    Electronic Resource
    Electronic Resource
    Book reviews (1989)
    Springer
    World journal of surgery 13 (1989), S. 658-662 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01658896
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Glucoseverwertung und Dynamik der Insulinsekretion Messungen nach intraabdominellen Operationen (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 861-865 
    Details
    ISSN: 1432-1440
    Keywords: Postoperative glucose assimilation ; insulin secretion in vivo ; insulin concentration in portal venous blood ; dynamics of insulin secretion ; oscillation in insulin response ; Postoperative Glucoseverwertung ; Insulinsekretion in vivo ; Insulinkonzentration im Pfortaderblut ; Dynamik der Insulinsekretion ; Oscillation der Insulinsekretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Insulinkonzentrationen im peripheren Venenblut und Pfortaderblut wurden während 20 standardisierter Glucoseinfusionstests bei 18 Patienten nach intraabdominellen Operationen gemessen. Folgende Schlußfolgerungen werden gezogen: 1. Trotz vergleichbarer präoperativer Ausgangssituation und Traumatisierung durch die Operation ist die Reaktivität des Inselzellapparates auf eine konstante Hyperglykämie und entsprechend die Glucoseverwertung individuell sehr verschieden. 2. Die Messungen der Insulinkonzentration im Pfortaderblut des Menschen ergeben eine signifikante Korrelation zwischen dem Profil der Insulinkonzentrationskurve und demk-Wert; die Meßergebnisse der Insulinkonzentration im peripher-venösen Blut zeigen trotz großerk-Wert-Unterschiede keine eindeutigen Beziehungen. 3. Bei den Patienten mit einer pathologischen Glucoseverwertung ist weniger die Geschwindigkeit der Insulinsekretion als die der Insulinregression aus dem Pfortaderblut verzögert. 4. Bei den Patienten mit einer normalen Glucoseverwertung zeigt die Insulinkonzentrationskurve im Pfortaderblut in den ersten 30 min einen oscillierenden Verlauf. Diese erstmals beim Menschen beobachteten Oscillationen weisen auf eine insulingesteuerte Rückkoppelung der Insulinsekretion hin.
    Notes: Summary Insulin concentrations in peripheral venous blood and portal venous blood were measured in 18 patients after intraabdominal operations during 20 standardised glucose-infusion-tests (GIT). The conclusion is as follows: 1. In spite of similar preoperative situations and operative traumatisation the islets reactivity to a constant hyperglycemia and the glucose assimilation is individually very different. 2. Measurements of insulin concentrations in the portal venous blood in man show a significant correlation between the profile of the insulin concentration curve and thek-value; the measurement of the insulin concentrations in peripheral venous blood fails to demonstrate a significant difference. 3. In patients with a pathologic glucose assimilation it is not the insulin secretion that is delayed but the insulin regression (disappearance rate) in portal venous blood. 4. In patients with a normal glucose assimilation the insulin concentration curve in portal venous blood shows an oscillating course during the first 30 min. These oscillations registered for the first time in humans indicate an insulin-induced feedback mechanism of insulin secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01466959
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  • 3
    Electronic Resource
    Electronic Resource
    The clinical significance of prostaglandins and thromboxane as mediators of septic shock (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 61-68 
    Details
    ISSN: 1432-1440
    Keywords: Septic shock ; Endotoxin ; Eicosanoids ; Prostaglandins ; Thromboxane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An evaluation was made of 106 surgical patients with Gram-negative septic shock, both for clinical criteria as well as the biochemical mediators endotoxin, prostaglandin F2α, prostaglandin I2 (prostacyclin), and thromboxane. These data were correlated to various defined shock phases, functional data of vital organs, and clinical outcome. Patients underwent invasive organ function monitoring and the usual laboratory tests of intensive care. Prostaglandins and thromboxane were measured radioimmunologically, endotoxin by the limulus amebocyte lysate test. Endotoxin proved to be a more accurate predictor of severe sepsis than did positive blood cultures. Endotoxin as well as prostaglandins and thromboxane are predominantly released in early shock phases, appearing in plasma concentrations, which correlate with the severity of organ failure. Sepsis-induced respiratory failure coincides with a deterioration of pulmonary prostaglandin inactivation, which contributes to the release mechanism. High systemic prostacyclin activity benefits the patients' organ functions and clinical outcomes, while a predominance of thromboxane seems to effect the opposite. Transpulmonary-thromboxane gradients correlate significantly with pulmonary hypertension in the early phases of septic shock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745474
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  • 4
    Electronic Resource
    Electronic Resource
    Preface (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 102-102 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711330
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  • 5
    Electronic Resource
    Electronic Resource
    A radiochemical test for phospholipase A2 catalytic activity (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 110-112 
    Details
    ISSN: 1432-1440
    Keywords: Phospholipase A2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A position-specifically labelled phosphatidylcholine is the substrate for the selective determination of Phospholipase A2 in serum, ascites and tissue samples. Optimal reaction conditions and simplifications of handling are discussed. A control group of human serum samples ranged up to 2.1 U/l. The maximum serum activity in samples of patients with acute pancreatitis was 126 U/l. In human ascites activities up to 380 U/l were measured. The method described here turned out to be a practicable instrument for the determination of phospholipase A2 activity using only commercially available reagents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711333
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  • 6
    Electronic Resource
    Electronic Resource
    Inhibition of porcine pancreas phospholipase A2 activation by gabexate mesilate (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 160-162 
    Details
    ISSN: 1432-1440
    Keywords: Phospholipase A2 ; Gabexate mesilate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the effect of gabexate mesilate on the catalytic activity of phospholipase A2 in homogenized porcine pancreatic tissue. Gabexate mesilate is a potent inhibitor of serine proteases. There is no direct inhibition of phospholipase A2 catalytic activity in concentrations up to 6 mmol/l. Preincubation of homogenized pancreatic tissue with gabexate mesilate leads to a reduction of phospholipase A2 activity even in concentrations as low as 6 µmol/l. The activation of purified porcine prophospholipase A2 added to pancreatic tissue can be completely inhibited. Thus, gabexate mesilate might influence the activation of phospholipase A2 administered in therapeutic concentrations in inflamed pancreatic tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711344
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  • 7
    Electronic Resource
    Electronic Resource
    Prognostic value of serum phospholipase A in acute pancreatitis (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 186-189 
    Details
    ISSN: 1432-1440
    Keywords: Human acute pancreatitis ; Immunoreactive phospholipase A2 ; Phospholipase A catalytic activity ; Pancreatic necrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum from 48 patients with acute pancreatitis (21 with interstitial-edematous and 27 with necrotizing pancreatitis) was monitored for immunoreactive (IR) phospholipase A2 (PLA2) protein concentration and PLA catalytic activity. In both groups within 48 h after start of acute pancreatitis an up to tenfold increase of IR-PLA2 was demonstrable. Determination of IR-PLA2 revealed no differences between the groups. In contrast, determination of PLA catalytic activity allowed us to differentiate between patients with interstitial-edematous and necrotizing pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711351
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  • 8
    Electronic Resource
    Electronic Resource
    Über den Einfuß der Leber auf die prä- und posthepatischen Konzentrationen des Plasmahistamins beim Menschen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 696-698 
    Details
    ISSN: 1432-1440
    Keywords: Histamine ; liver ; portal and hepatic vein plasma histamine ; Histamin ; Leber ; Plasmahistamin in Pfortader und Lebervene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Plasmahistaminkonzentrationen wurden bei 8 Patienten im Blut der Pfortader, der Lebervene, der Femoralarterie und systemvenös fluorimetrisch bestimmt. Der von der Leber eliminierte Histaminanteil, errechnet aus der Differenz des portal einströmenden und des über die Lebervene ausströmenden Plasmahistamins, beträgt bei arterieller Beimischung von 30% im Mittel 63,1±12,8%. Auf die Fähigkeit der Leber durch unterschiedlich große Eliminierung des Histamins den Plasmahistamingehalt zu regulieren wird hingewiesen.
    Notes: Summary Fluorometric estimations of plasma histamine in the blood of the portal vein, hepatic vein, cubital vein and the femoral artery were performed in 8 patients. Concerning the difference of histamine in the portal and the hepatic vein blood, the histamine elimination of the liver comes to 63.1±12.8 per cent. The human liver seems to be important in the regulation of the plasma histamine concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468481
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  • 9
    Electronic Resource
    Electronic Resource
    Profil der Glucosestimulierten Insulinsekretion im Pfortaderblut des Menschen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 575-577 
    Details
    ISSN: 1432-1440
    Keywords: Insulin secretion in vivo ; oscillation in insulin response curve ; liver extraction of insulin ; glucose metabolism in early postoperative period ; Insulinsekretion in vivo ; Oscillation der Insulinsekretionskurve ; Insulin Leberextraktion ; Glucosestoffwechsel der frühen postoperativen Phase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Insulinkonzentration im Pfortaderblut bei 8 Patienten in der frühen postoperativen Phase zeigt unter konstanter Glucoseinfusion einen vielgipfligen Verlauf. Die Unterschiede zwischen Gipfel und Täler sind signifikant. Lediglich initialer und der am stärksten ausgeprägte sekundäre Gipfel sind auch im Cubitalvenenblut zu beobachten. Die Rolle der Leber als Puffer gegenüber überschüssig sezerniertem Insulin wird diskutiert.
    Notes: Summary The concentration of insulin in the portal venous blood shows in 8 patients in the early postoperative period under constant infusion of glucose a multiphasic course. The differences between the highest and lowest points are significant. Only the initial and the most prominent secondary peak can be followed up in the cubital venous blood. The role of the liver as buffer against the surplus of secreted insulin is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468499
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  • 10
    Electronic Resource
    Electronic Resource
    Insulinkonzentrationen im Pfortaderblut des Menschen nac Glucose-Infusion (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 404-406 
    Details
    ISSN: 1432-1440
    Keywords: Glucose metabolism ; postoperative dynamic of insulin secretion ; portal-vein-insulin-concentration in man ; hepatic binding of human endogenous insulin ; Glucosestoffwechsel ; Dynamik der post-operativen Insulinsekretion ; Insulinkonzentrationen im Pfortaderblut des Menschen ; endogener Insulinverbrauch der Leber beim Menschen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der frühen postoperativen Phase wurde bei neun lebergesunden Patienten die Insulin-Konzentration in der Pfortader vor, während und nach i.v. Glucosestimulation gemeseen. Die in der Pfortader gemessenen Insulinkonzentrationen ergaben einen doppelgipfeligen Kurvenverlauf. Die Differenz der Insulin-Konzentration zwischen Pfortader und Cubitalvene ist unterschiedlich und schwankt zwischen 44 und 83%.
    Notes: Summary In the early postoperative period the insulin concentration of the portal vein was measured by 9 patients, before, during and after intravenous glucose stimulation. The insulin concentrations of the portal vein show a biphasic curve. The inconstant difference of the insulin level in the portal and systemic blood fluctuates between 44–83%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468443
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