Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    1,3-Diphenylpropane-1,3-diamines, X: Synthesis and biochemical evaluation of highly substituted 1,3-diphenylpropane-1,3-diamines and preparation of their Pt(II) complexes (1996)
    Springer
    Monatshefte für Chemie 127 (1996), S. 1073-1080 
    Details
    ISSN: 1434-4475
    Keywords: 1,3-Diphenylpropane-1,3-diamines ; Receptor binding affinity ; Estrogenic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Liganden der Titelverbindungen1 und2 wurden aus dem entsprechenden Chalcon5 mit Hydrazinhydrat und anschließende N-N-Spaltung hergestellt. Die oestrogene Wirkung der Diamine11 und12 wurde im Rezeptorbindungstest an Kalbsuterus-Zytosol und durch einen Luziferase-Test an MCF 7-2a-Zellen bestimmt. Die Verbindungen wirken viel schwächer alsSchönenbergers aktivste Substanz ([meso-1,2-Bis(2,6-dichlor-4-hydroxyphenyl)ethan-1,2-diamin]dichloro-Platin(II),3).
    Notes: Summary The ligands of the title complexes1 and2 were prepared from the pertinent chalcone5 and hydrazine hydrate, followed by N-N cleavage. The estrogenic activity of the diamines11 and12 was determined by measuring the RBA values (calf uterine cytosol) and by a luciferase test in MCF 7-2a cells. The compounds are by far less active thanSchönenberger's most active compound ([meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethane-1,2-diamine]dichloro-platinum(II),3).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00807580
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    1,3-Diphenylpropane-1,3-diamines XI. Conversion of a 3-hydroxy-1,3-diphenylpropan-1-one to 1,3-diphenylpropane-1,3-diamines (1997)
    Springer
    Monatshefte für Chemie 128 (1997), S. 1247-1254 
    Details
    ISSN: 1434-4475
    Keywords: 1,3-Diphenylpropane-1,3-diamines ; 3-Hydroxy-1,3-diphenylpropan-1-one ; 3,5-Diphenyl-4,5-dihydropyrazole ; syn-Reduction of β-hydroxyketones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Hochdiastereoselektive BH3/THF-syn-Reduktion des 3-Hydroxy-1,3-diphenylpropan-3-on/BBr3-Komplexes3/BBr3 (vergl.Sarko) lieferte dasmeso-Diol4, wähend das Razemat5 durch BH3/THF-Reduktion ohne Komplexbildung entstand. Mesylierung, Ersatz von Mesylat durch Azid und SnCl2/Thiophenol-Reduktion führte zu den Diaminen10 und11, die auch durch reduktive N-N-Spaltung aus dem 4,5-Dihydropyrazol13 erhalten wurden.
    Notes: Summary Highly diastereoselective BH3/THF syn-reduction of the 3-hydroxy-1,3-diphenylpropan-1-one/BBr3 complex3/BBr3 (cf.Sarko) afforded themeso-diol4, whereas racemate5 was obtained by BH3/THF reduction without complexation. Mesylation, exchange of mesylate by azide, and reduction with SnCl2/thiophenol led to the diamines10 and11 which were also produced by reductive N-N cleavage of the 4,5-dihydropyrazole13.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00807256
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...