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  • 1
    Electronic Resource
    Electronic Resource
    Severe steroid-unresponsive ulcerative colitis (2000)
    Springer
    Diseases of the colon & rectum 43 (2000), S. 609-613 
    Details
    ISSN: 1530-0358
    Keywords: Cyclosporin ; Steroid-refractory ulcerative colitis ; Subtotal colectomy ; Immune suppressor drugs ; Surgical outcomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The recent introduction of the immune suppressor cyclosporin for treatment of steroid-refractory ulcerative colitis has required surgeons to perform a colectomy in those patients who eventually fail this rescue treatment, thus raising questions as to the safety of surgery as performed in patients with a heavily manipulated immune system. To assess the rates of mortality and morbidity in this setting, we studied a cohort of consecutive patients who had surgery after failing cyclosporin for refractory ulcerative colitis at our center. METHODS: Between January 1991 and December 1996, 25 patients with ulcerative colitis underwent restorative proctocolectomy performed in three steps (21 patients) and in two steps (4 patients). Seventeen of the 25 patients (68 percent) were initial nonresponders to a dose of 2 mg/kg/day of intravenous cyclosporin and underwent surgery immediately, the remaining 8 (32 percent) relapsed as outpatients on oral cyclosporin and were readmitted for surgery. RESULTS: There was no operative mortality. Nine patients of the 25 developed postoperative (early) complications (36 percent). The three-step operation subset had a 28 percent complication rate, the two-step 75 percent. Three patients needed reoperation. A total of 11 patients (44 percent) reported with late complications: two patients required surgical treatment, one for obstruction and one for pouch-perianal fistula. Three cases of pouchitis were recorded. No patient required pouch removal. CONCLUSION: Given the absence of postoperative mortality and a low overall complication rate, restorative proctocolectomy can safely be perofrmed in patients who fail rescue treatment with a dose of 2 mg/kg of cyclosporin for steroid-refractory ulcerative colitis. Corollary evidence in this article hints but does not prove that the three-step procedure is safer than the two-step operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02235571
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  • 2
    Electronic Resource
    Electronic Resource
    Persistence of azacytidine-induced SCEs and genomic methylation in CHO cells in vitro
    Amsterdam : Elsevier
    Mutation Research Letters 245 (1990), S. 211-215 
    Details
    ISSN: 0165-7992
    Keywords: Azacytidine ; DNA methylation ; Sister-chromatid exchange
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-7992(90)90052-L
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  • 3
    Electronic Resource
    Electronic Resource
    Antimutagenic activities of naturally occuring polyamines in CHO cells
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 234 (1990), S. 376-377 
    Details
    ISSN: 0165-1161
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1161(90)90067-X
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  • 4
    Electronic Resource
    Electronic Resource
    Modelling of growth of Corynebacterium glutamicum under biotin limitation (1997)
    Springer
    Bioprocess engineering 17 (1997), S. 121-125 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  One of the prerequisites for the successful production of L-glutamic acid with Corynebacterium glutamicum is the realization of adequate growth under biotin limiting conditions. The intracellular biotin content, i.e. the specific biotin concentration is shown to be the limiting factor for growth in this fermentation process. Modelling of growth is then examined with logistic models and Monod kinetics. For the description of the lag phase different extensions of kinetics are compared respectively tested and two new mathematical functions suggested for this purpose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008956
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  • 5
    Electronic Resource
    Electronic Resource
    Modelling of the L-glutamic acid production with Corynebacterium glutamicum under biotin limitation (1997)
    Springer
    Bioprocess engineering 17 (1997), S. 139-142 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Production of L-glutamic acid with Corynebacterium glutamicum, under biotin limitation was studied. On the base of formal kinetic approach, a mathematical model was developed, which included formal growth inhibition with product, and production repression with substrate. For the testing of computer simulations experiments were carried out and the results have been compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008961
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  • 6
    Electronic Resource
    Electronic Resource
    Modelling L-glutamic acid production with Corynebacterium glutamicum under biotin limitation (1997)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 17 (1997), S. 327-337 
    Details
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The production of L-glutamic acid with Corynebacterium glutamicum under biotin limitation was studied. Assuming a formal type of cell maturation, an adequate formal kinetic model was developed. This model includes growth, dependent on biotin, and uses the same retention term for describing the lag phase and cell maturation. Special attention was paid to the graphical interpretation of the performance between the variables, which is relevant for kinetics. Comparison between experiments and the model resulted in different degrees of agreement. However, the main trend of the experimental patterns of the complex bioprocess can clearly be mirrored in this model.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/abio.370170408
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