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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 41 (1986), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a case of a young female who developed multiple life threatening complications after a single internal jugular vein catheterisation. They consisted of pleural misplacement of the catheter. massive haemorrhage with cardiovascular collapse following catheter removal, and development of arteriovenous fistula, diagnosed 18 months later.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Urban Economics 4 (1977), S. 45-59 
    ISSN: 0094-1190
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1106
    Keywords: Blinks ; Botulinum toxin ; Blepharospasm ; Orbicularis oculi ; Monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The alterations induced in eyelid movement metrics subsequent to unilateral injections of botulinum toxin type A into the orbicularis oculi muscle were studied in chronic alert monkeys using the search coil technique. Botulinum toxin caused rapid paralysis of blinks in the treated eyelid. The amplitude and peak velocity of blinks generated by this eyelid remained at or below 20% of that of the fellow, untreated eyelid for 10–20 days. Blink amplitude gain increased linearly thereafter, attaining control values by 40–60 days after injection. Recovery of blink peak velocity was slower. The adaptive alterations in blink duration that were observed during the acute phase of toxin paralysis suggest that the mechanisms responsible for blink reflex plasticity may produce bilateral adjustments in eyelid function. Taken together, these data establish a quantitative data base that can be exploited in order to: (1) better understand the neural adaptive mechanisms that operate during eyelid movements and (2) allow quantitative comparisons between current treatment protocols that employ botulinum toxin and protocols that may lead to improvements in the treatment of chronic eyelid spasm (blepharospasm).
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1238
    Keywords: Glyceryl trinitrate ; Isosorbide dinitrate ; Sodium nitroprusside ; Coronary blood flow ; Myocardial oxygen consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influences of glyceryl trinitrate, isosorbide dinitrate and sodium nitroprusside intravenously on haemodynamics, coronary circulation and myocardial oxygen consumption were investigated in closed chest dogs (n=8). In an attempt to simulate heart failure the dogs received blood transfusion (15 ml/kg) in the presence of halothane-induced myocardial depression. All three nitrates reduced the loads for the left ventricle. With isosorbide dinitrate and sodium nitroprusside the preload and pulmonary pressure decreased to a greater extent than with glyceryl trinitrate. The haemodynamic results suggest that sodium nitroprusside is the favourable nitrate in left ventricular failure because it produces a balanced reduction in the ratio of pre- and afterload. Four μg/kg·min sodium nitroprusside induced marked coronary dilatation; glyceryl trinitrate had only a slight coronary vasodilating effect. With isosorbide dinitrate the myocardial blood flow remained well adapted to oxygen demand, the coronary vascular resistance did not change. Sodium nitroprusside produced a significant change of the transmural myocardial blood distribution-expressed as the epi/endocardial blood flow ratio. The ratio was increased by sodium nitroprusside, much more than by glyceryl trinitrate or isosorbide dinitrate.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 62 (1991), S. 385-389 
    ISSN: 1439-6327
    Keywords: Energy cost of running ; Distance ; Fatigue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The net energy cost of running per unit of body mass and distance (Cr, ml O2·kg−1·km−1) was determined on ten amateur runners before and immediately after running 15, 32 or 42 km on an indoor track at a constant speed. The Cr was determined on a treadmill at the same speed and each run was performed twice. The average value of Cr, as determined before the runs, amounted to 174.9 ml O2·kg−1·km−1 SD 13.7. After 15 km, Cr was not significantly different, whereas it had increased significantly after 32 or 42 km, the increase ranging from 0.20 to 0.31 ml O2·kg−1·km−1 per km of distance (D). However, Cr before the runs decreased, albeit at a progressively smaller rate, with the number of trials (N), indicating an habituation effect (H) to treadmill running. The effects of D alone were determined assuming that Cr increased linearly with D, whereas H decreased exponentially with increasing N, i.e.C r =C r0+aD+He−bN. The Cro, the “true” energy cost of running in nonfatigued subjects accustomed to treadmill running, was assumed to be equal to the average value of Cr before the run for N equal to or greater than 7 (171.1 ml O2·kg−1·km−1, SD 12.7;n = 30). A multiple regression of Cr on N and D in the form of the above equation showed firstly that Cr increased with the D covered by 0.123%·km−1, SEM 0.006 (i.e. about 0.22 ml O2·kg−1·km−1 per km,P〈0.001); secondly, that in terms of energy consumption (obtained from oxygen consumption and the respiratory quotient), the increase of Cr with D was smaller, amounting on average to 0.08%·km−1 (0.0029 J·kg−1·m−1,P〈0.001) and thirdly that the effects of H amounted to about 16% of Cr0 for the first trial and became negligible after three to four trials.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 55 (1986), S. 259-266 
    ISSN: 1439-6327
    Keywords: Endurance running ; Energy cost of running ; Running performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Maximal O2 consumption ( $$\dot V_{O_{_2 max} } $$ and energy cost of running per unit distance (C) were determined on the treadmill in 36 male amateur runners (17 to 52 years) who had taken part in a marathon (42.195 km) or semi-marathon (21 km), their performance times varying from 149 to 226 and from 84 to 131 min, respectively. $$\dot V_{O_{_2 max} } $$ was significantly (2p〈0.001) greater in the marathon runners (60.6 vs 52.1 ml · kg−1 · min−1) whileC was the same in both groups (0.179±0.017, S.D., mlO2 · kg−1 · m−1 above resting), and independent of treadmill speed. It can be shown that the maximal theoretical speed in endurance running (vEND) is set by $$\dot V_{O_{_2 max} } $$ , its maximal sustainable fraction (F), andC, as described by:vEND=F · $$\dot V_{O_{_2 max} } $$ ·C −1. SinceF was estimated from the individual time of performance,vEND could be calculated. The average speed of performance (vMIG) andvEND (m · s−1) were found to be linearly correlated:vMIG=1.12+0.64vEND (r 2=0.72;n=36). The variability ofvMIG explained byvEND, as measured byr 2, is greater than that calculated from any one regression betweenvMIG and $$\dot V_{O_{_2 max} } $$ (r 2=0.51),F · $$\dot V_{O_{_2 max} } $$ (r 2=0.58), or $$\dot V_{O_{_2 max} } $$ ·C −1 (r 2=0.63). The mean ratio of observed (vMIG) to theoretical (vEND) speeds amounted to 0.947±0.076 and increased to 0.978±0.079 (±S.D.;n=36) when the effects of air resistance were taken into account. It is concluded thatvEND=F · $$\dot V_{O_{_2 max} } $$ ·C −1 is a satisfactory quantitative description of the energetics of endurance running.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An intakten Hunden wurde der Einfluß einer isolierten metabolischen Azidose (HCl-Infusion, n=12) auf die Myokarddurchblutung mit den Koronarwirkungen einer durch Hyperkapnie induzierten Azidose (Beatmung mit 5% CO2, n=5) unter den Bedingungen einer Allgemeinnarkose verglichen. Eine metabolische Azidose führte (bei normalen arteriellen Kohlensäuredrucken) unterhalb eines pH-Wertes von 7,2 zu einer Steigerung der Koronardurchblutung, zu einer Abnahme des Koronarwiderstandes und der arterio-koronarvenösen Sauerstoffgehaltsdifferenz, d. h., zu einer primären Koronardilatation bei gleichbleibendem myokardialem Sauerstoffverbrauch. Da sich dieser Effekt bei Tieren, die mit Propranolol vorbehandelt waren, nicht nachweisen ließ, ist anzunehmen, daß eine β-Stimulation unter den gegebenen Versuchsbedingungen mittelbar oder unmittelbar wesentlichen Anteil an den Koronarwirkungen einer metabolischen Azidose hat. Unter den Bedingungen einer Hyperkapnie wurde ebenfalls eine Koronardilatation beobachtet, diese war jedoch deutlich stärker ausgeprägt als bei gleich großer Säuerung mit HCl und ließ sich durch Vorbehandlung mit Propranolol nicht blockieren. Diese Befunde lassen den Schluß zu, daß die koronardilatierende Wirkung hoher arterieller Kohlensäuredrücke nicht auf eine β-adrenerge Stimulation zurückzuführen ist und unabhängig von der begleitenden Zunahme der Wasserstoffionenkonzentration auftritt. Der Wirkungsort wird diskutiert.
    Notes: Summary The effect of metabolic and hypercapnic acidosis on myocardial blood flow was studied during intravenous infusions of hydrochloric acid solutions (n=12) and during passive ventilation with 5% CO2 (n=5) in anaesthetized, closed chest dogs. Below a pH of 7.2 metabolic acidosis at normal arterial CO2-tensions caused an increase of coronary blood flow and a decrease of coronary vascular resistance associated with a narrowed myocardial arteriovenous O2-difference, indicating vasodilation at unchanged myocardial oxygen consumption. In propranolol-pretreated dogs myocardial blood flow and coronary oxygen AV difference remained unaffected, suggesting that the coronary dilatory effect of metabolic acidemia involves beta adrenergic stimulation. Coronary vasodilation induced by increasing arterial pCO2 was found to the significantly greater as compared with the dilatory effect of metabolic acidosis at the same blood pH level. Blocking of beta receptors did not reduce the coronary response to increased arterial CO2-tensions. It is concluded that the coronary vasodilation observed during hypercapnic acidosis is neither mediated by a beta adrenergic stimulation nor dependent of the concomitant change in blood pH. The possible sites of the coronary dilatory actions of increased arterial CO2-tensions are discussed.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract An X-ray/gamma-ray spectrometer has been developed as part of a rendezvous mission with the near-Earth asteroid, 433 Eros, in an effort to answer fundamental questions about the nature and origin of asteroids and comets. During about 10 months of orbital operations commencing in early 1999, the X-ray/Gamma-ray Spectrometer will develop global maps of the elemental composition of the surface of Eros. The instrument remotely senses characteristic X-ray and gamma-ray emissions to determine composition. Solar excited X-ray fluorescence in the 1 to 10 keV range will be used to measure the surface abundances of Mg, Al, Si, Ca, Ti, and Fe with spatial resolutions down to 2 km. Gamma-ray emissions in the 0.1 to 10 MeV range will be used to measure cosmic-ray excited elements O, Si, Fe, H and naturally radioactive elements K, Th, U to surface depths on the order of 10 cm. The X-ray spectrometer consists of three gas-filled proportional counters with a collimated field of view of 5° and an energy resolution of 850 eV @ 5.9 keV. Two sunward looking X-ray detectors monitor the incident solar flux, one of which is the first flight of a new, miniature solid-state detector which achieves 600 eV resolution @ 5.9 keV. The gamma-ray spectrometer consists of a NaI(Tl) scintillator situated within a Bismuth Germanate (BGO) cup, which provides both active and passive shielding to confine the field of view and eliminate the need for a massive and costly boom. New coincidence techniques enable recovery of single and double escape events in the central detector. The NaI(Tl) and BGO detectors achieve energy resolutions of 8.7% and 14%, respectively @ 0.662 MeV. A data processing unit based on an RTX2010 microprocessor provides the spacecraft interface and produces 256-channel spectra for X-ray detectors and 1024-channel spectra for the raw, coincident, and anti-coincident gamma-ray modes. This paper presents a detailed overview of the X-ray/Gamma-ray Spectrometer and describes the science objectives, measurement objectives, instrument design, and shows some results from early in-flight data.
    Type of Medium: Electronic Resource
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