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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 250 (1974), S. 95-107 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 21 auslesefreie stationäre Patienten mit Psoriasis (7 ♀, 14 ♂) wurden klinisch, röntgenologisch und szintigraphisch (6 mCi99mTc-Pertechnetat, 4 mCi99mTc-Pyrophosphat) im Hinblick auf eine Gelenkbeteiligung untersucht. 5 davon konnten als Psoriasis arthropathica herkömmlicher Begriffsfassung eingeordnet werden und weitere 8 gaben nach mehrfachem Befragen Gelenkbeschwerden in der Anamnese an. Hingegen zeigte sich bei 20 der 21 untersuchten Kranken in zumindest einem Gelenk bzw. Gelenkgruppe eine pathologische Aktivitätsanreicherung. Darunter waren auch Frühformen wenig ausgedehnter Fälle von Psoriasis guttata u. a. bei Jugendlichen. Wie röntgenologisch bekannt, waren auch szintigraphisch die kleinen Gelenke bevorzugt befallen. Ebenso zeigte sich die Asymmetrie des Gelenkbefalls. Es hat den Anschein, daß mit den sehr empfindlichen Methoden der Gelenk- und Knochenszintigraphie eine Früherfassung von Gelenkbeteiligung bei Psoriasis möglich ist, die in vielen Fällen offenbar eine bestimmte Entwicklungsstufe nicht überschreitet. Hiernach geht die Dermatose Psoriasis mit einer mehr/minder obligaten, spezifischen arthropathischen Komponente als weiterer extracutaner Manifestationsform einher, die von der primär chronischen Polyarthritis klar abzutrennen ist. Die früh erfaßbaren pathologischen gelenkszintigraphischen Befunde weisen auf ein entzündliches Geschehen hin, weshalb sie nur noch Arthritis psoriatica genannt werden sollen.
    Notes: Summary 21 unselected hospital patients with psoriasis (7 female, 14 males) were examined for joint lesions by clinical, roentgenological and scintigraphical methods (6 mCi99mTc-Pertechnetate, 4 mCi99mTc-Pyrophosphate). According to traditional concepts only 5 patients suffered from psoriatic arthropathy, in 8 other patients an extensive case history revealed some joint complaints. By scintigraphical methods 20 out of 21 patients demonstrated a pathological uptake of radionuclides in at least one joint or joint group. Within these cases there were early manifestations of guttate psoriasis in juveniles with a low degree of extension. As known by X-ray-findings scans demonstrated a favoured localisation of the lesions in small joints and an asymmetrical pattern of joint changes. In psoriasis it seems to be possible to obtain an early recognition of joint manifestations by aid of these highly sensitive scintigraphical methods. These joint lesions probably do not exceed a certain degree of development. Thereafter psoriasis is correlated to a more or less obligate specific arthropathic component as an other extracutaneous manifestation that should be differentiated clearly from rheumatoid arthritis. According to the fact that early recognizable pathological findings in joint scans indicate an inflammatory process these joint lesions should be called “psoriatic arthritis”.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 262 (1978), S. 191-196 
    ISSN: 1432-069X
    Keywords: Psoriasis ; Psoriatic arthritis ; Bone-scanning ; Psoriasis ; Psoriasis-Arthritis ; Knochenscintigraphie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter 40 mit der Ganzkörperscintigraphie (Technetium-Diphosphonat) untersuchten Psoriatikern fanden sich bei 3 Patientinnen diffuse und umschriebene pathologisch gesteigerte Nuklidanreicherungen im Schädelskelet. Diese gelenkfernen Proliferationszeichen im Knochenbereich weisen ebenso wie der gegenüber dem Gelenkscan häufiger positive Knochenscan auf eine Frühbeteiligung des knöchernen Skelets bei Psoriasis hin.
    Notes: Summary Three female patients out of 40 psoriatics examined with scintigraphical methods (Tc-diphosphonate) were found to have a diffuse and circumscribed pathological increase of nuclide at the skull. These abarticular signes of proliferation at the bone-area indicate an early affection of skeleton of patients with psoriasis which is similar to the joint-scan that is mostly obtained in positive bone-scan.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2072
    Keywords: Key words EMD 57445 ; Sigma receptor ; Antipsychotic ; Dopamine receptor ; Iodobenzamide ; Single photon emission computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: EMD 57445 (panamesine) is a high affinity sigma ligand with the profile of an atypical antipsychotic in animal studies. It has been reported recently to have antipsychotic activity in schizophrenia. However, its metabolite, EMD 59983, binds also to D2 and D3 dopamine (DA) receptors. Objectives: The aim of this study was to test, using single photon emission computed tomography (SPECT) and [123I]iodobenzamide (IBZM) as the radiotracer, whether EMD 59983 would pass the blood-brain barrier and to what extent it would contribute to the effects of EMD 57445 in schizophrenia. Methods: Two IBZM SPECT-scans were performed in five neuroleptic-free schizophrenic patients (DSM IV), one before and one after treatment with 60 mg panamesine daily for a treatment duration of 12–26 days. Results: A high occupancy of striatal D2-like DA receptors similar to that induced by typical neuroleptics was observed in all patients treated with EMD 57445. Conclusions: Our results suggest that a possible antipsychotic activity of EMD 57445 in schizophrenia is not necessarily attributable to its affinity for sigma receptors, but could be simply due to the potent antidopaminergic effects of EMD 59983, its main metabolite.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1619-7089
    Keywords: Technetium 99m hexakis ; 2-Methoxyisobutylisonitrile ; First-pass radionuclide angiocardiography ; Ventricular function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the context of a multicentre study on the use of technetium 99m hexakis-2-methoxyisobutylisonitrile (99mTc-Sestamibi), we evaluated the accuracy of the ventricular function assessed at rest by means of first-pass radionuclide angiocardiography acquired during the injection of the tracer for myocardial perfusion scintigraphy. The results were compared with first-pass studies performed using reference tracers sodium pertechnetate Tc 99m or technetium 99m diethylene triamine penta-acetic acid or with gated radionuclide angiocardiography. A total of 66 patients of the 105 enrolled in the study could be evaluated. The comparison of the first-pass studies was possible in 33 subjects with regard to the left ventricular ejection fraction, yieldingr=0.909 (P〈 10−6), and in 22 cases with regard to the right ventricular ejection fraction, yieldingr=0.712 (P〈0.001). The comparison between the first-pass study using99mTc-Sestamibi and the equilibrium gated radionuclide angiocardiography was possible for the left ventricular ejection fraction in 26 cases, withr=0.937 (P〈10−6), and for the right ventricular ejection fraction in 15 subjects, withr=0.783 (P〈0.001). In conclusion, the assessment of ventricular function performed by acquiring a first-pass radionuclide angiocardiograph during the injection of99mTc-Sestamibi for perfusion myocardial scintigraphy can be considered reliable and accurate, when compared with the usually employed techniques. This result confirms the feasibility of a combined evaluation of perfusion and function at rest and during stress testing, which represents one of the most interesting advantages offered by the use of99mTc-Sestamibi.
    Type of Medium: Electronic Resource
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