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  • 1
    Electronic Resource
    Electronic Resource
    Spatiotemporal dynamics of RhoA activity in migrating cells (2006)
    [s.l.] : Nature Publishing Group
    Nature 440 (2006), S. 1069-1072 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Rho family GTPases regulate the actin and adhesion dynamics that control cell migration. Current models postulate that Rac promotes membrane protrusion at the leading edge and that RhoA regulates contractility in the cell body. However, there is evidence ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04665
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  • 2
    Electronic Resource
    Electronic Resource
    Assessment of ventricular function with first-pass radionuclide angiography using technetium 99m hexakis-2-methoxyisobutylisonitriIe: a European multicentre study (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 178-183 
    Details
    ISSN: 1619-7089
    Keywords: Technetium 99m hexakis ; 2-Methoxyisobutylisonitrile ; First-pass radionuclide angiocardiography ; Ventricular function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the context of a multicentre study on the use of technetium 99m hexakis-2-methoxyisobutylisonitrile (99mTc-Sestamibi), we evaluated the accuracy of the ventricular function assessed at rest by means of first-pass radionuclide angiocardiography acquired during the injection of the tracer for myocardial perfusion scintigraphy. The results were compared with first-pass studies performed using reference tracers sodium pertechnetate Tc 99m or technetium 99m diethylene triamine penta-acetic acid or with gated radionuclide angiocardiography. A total of 66 patients of the 105 enrolled in the study could be evaluated. The comparison of the first-pass studies was possible in 33 subjects with regard to the left ventricular ejection fraction, yieldingr=0.909 (P〈 10−6), and in 22 cases with regard to the right ventricular ejection fraction, yieldingr=0.712 (P〈0.001). The comparison between the first-pass study using99mTc-Sestamibi and the equilibrium gated radionuclide angiocardiography was possible for the left ventricular ejection fraction in 26 cases, withr=0.937 (P〈10−6), and for the right ventricular ejection fraction in 15 subjects, withr=0.783 (P〈0.001). In conclusion, the assessment of ventricular function performed by acquiring a first-pass radionuclide angiocardiograph during the injection of99mTc-Sestamibi for perfusion myocardial scintigraphy can be considered reliable and accurate, when compared with the usually employed techniques. This result confirms the feasibility of a combined evaluation of perfusion and function at rest and during stress testing, which represents one of the most interesting advantages offered by the use of99mTc-Sestamibi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02262728
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  • 3
    Electronic Resource
    Electronic Resource
    Relationship between clinical features of Parkinson’s disease and presynaptic dopamine transporter binding assessed with [123I]IPT and single-photon emission tomography (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 415-421 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Dopamine transporter ; Cocaine analogues ; Single-photon emission tomography ; Parkinson’s disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. IPT [N-(3-iodopropen-2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl) tropane] is a new cocain analogue which allows the presynaptic dopamine transporters to be imaged with single-photon emission tomography (SPET) as early as 1–2 h post injection. In the present study [123I]IPT SPET was performed in patients with Parkinson’s disease (PD) to analyse the relationship between specific dopamine tansporter binding and clinical features of the disease. Twenty-six PD patients (Hoehn and Yahr stages I–IV, age range 40–79 years) and eight age-matched controls were studied. SPET imaging was performed 90–120 min after injection of 160–185 MBq [123I]IPT using a triple-head camera. For semiquantitative evaluation of specific [123I]IPT binding, ratios between caudate, putamen and background regions were calculated. Specific [123I]IPT uptake was significantly reduced in PD patients compared to controls. Most patients showed a marked asymmetry with a more pronounced decrease in [123I]IPT binding on the side contralateral to the predominant clinical findings. The putamen was always more affected than the caudate. [123I]IPT binding was significantly correlated with disease duration (r=−0.7, P〈0.0001) but not with the age of PD patients (r=−0.10, P=0.61). Specific [123I]IPT uptake in the caudate and putamen, and putamen to caudate ratios, decreased with increasing Hoehn and Yahr stage. Our findings indicate that [123I]IPT SPET may be a useful technique to estimate the extent of nigrostriatal degeneration in PD patients. Close relationships between striatal [123I]IPT binding and clinical features of the disease suggest that this method can be used to objectively follow the course and progression of PD. The reduced putamen to caudate ratios observed even in patients with mild, newly recognized symptoms indicate that particularly this parameter may help to establish the correct diagnosis in the early course of PD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881814
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  • 4
    Electronic Resource
    Electronic Resource
    [123I]IPT binding to the presynaptic dopamine transporter: variation of intra- and interobserver data evaluation in parkinsonian patients and controls (2000)
    Springer
    European journal of nuclear medicine 27 (2000), S. 1809-1812 
    Details
    ISSN: 1619-7089
    Keywords: Dopamine transporter [123I]IPT Interobserver variability Intraobserver variability Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Imaging the presynaptic dopamine transporter with cocaine analogues and single-photon emission tomography (SPET) has proven to be a potential diagnostic tool for classifying the extent and degree of dopaminergic nerve cell loss. For correct interpretation of scan results, however, knowledge of the intra-/interobserver variation of data evaluation is mandatory. Iodine-123 labelled N-(3-iodopropen-2-yl)-2β-carbomethoxy-3β-(chlorophenyl)tropane ([123I]IPT) SPET data of 10 controls and 30 parkinsonian patients with varying degrees of reduced IPT binding were analysed twice by an expert (intraobserver) and once by a less experienced physician in training (interobserver). For semiquantitative evaluation of specific IPT binding, ratios between total striatum, caudate and putamen and a background region were calculated. No significant differences were observed for either the intra- or the interobserver analyses. Variation was lower in controls than in the patient group. Overall variation indices were below 5%. Variation in interobserver results was only slightly higher than that in intraobserver results. The intra-/interobserver results showed highly significant correlations (r=0.99). The intraclass correlation was higher than 0.9 for all evaluations. Our results indicate that the specific presynaptic striatal dopamine transporter binding assessed with IPT-SPET may be reproducibly analysed by the same and different observers in controls as well as in patients with varying degrees of reduced binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590000384
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  • 5
    Electronic Resource
    Electronic Resource
    Technetium-99m mercaptoacetyltriglycine clearance: reference values for infants and children (1995)
    Springer
    European journal of nuclear medicine 22 (1995), S. 1278-1281 
    Details
    ISSN: 1619-7089
    Keywords: MAG 3 clearance ; Reference values for infants and children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six hundred and thirty-nine clearance studies performed in children aged 7 days to 19 years utilizing technetium-99m mercaptoacetyltriglycine (MAG 3) were retrospectively analysed. Standardized conditions for the investigation included: parenteral hydration (60 ml/hxm2 body surface) in addition to normal oral fluid intake, weight-related dose of99mTc-MAG 3 (1 MBq/kg body weight, minimum 15 MBq) and calculation of clearance according to Bubeck et al. Of the 513 children, 169 included in this analysis could be classified as “normal” with regard to their renal function. Normal kidney function was judged by the following criteria: normal GFR for age, normal tubular function (absence of proteinuria and glucosuria), normal renal parenchyma (on ultrasonography, MAG 3 scan and intravenous pyelography), absence of significant obstruction and gross reflux (〉grade 1), no single kidney and no difference in split renal function 〉20%. Results showed increasing MAG 3 clearance values for infants during the first months of life, reaching the normal range for older children and adults between 7 and 12 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801613
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  • 6
    Electronic Resource
    Electronic Resource
    Relationship between clinical features of Parkinson's disease and presynaptic dopamine transporter binding assessed with [123I]IPT and single-photon emission tomography (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 415-421 
    Details
    ISSN: 1619-7089
    Keywords: Dopamine transporter ; Cocaine analogues ; Single-photon emission tomography ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract IPT [N-(3-iodopropen-2-yl)-2β-carbome-thoxy-3β-(4-chlorophenyl) tropane] is a new cocain analogue which allows the presynaptic dopamine transporters to be imaged with single-photon emission tomography (SPET) as early as 1–2 h post injection. In the present study [123I]IPT SPET was performed in patients with Parkinson's disease (PD) to analyse the relationship between specific dopamine tansporter binding and clinical features of the disease. Twenty-six PD patients (Hoehn and Yahr stages I-IV, age range 40–79 years) and eight age-matched controls were studied. SPET imaging was performed 90–120 min after injection of 160–185 MBq [123I]IPT using a triple-head camera. For semiquantitative evaluation of specific [123I]IPT binding, ratios between caudate, putamen and background regions were calculated. Specific [123I]IPT uptake was significantly reduced in PD patients compared to controls. Most patients showed a marked asymmetry with a more pronounced decrease in [123I]IPT binding on the side contralateral to the predominant clinical findings. The putamen was always more affected than the caudate. [123I]IPT binding was significantly correlated with disease duration (r=−0.7,P〈0.0001) but not with the age of PD patients (r=−0.10,P=0.61). Specific [123I]IPT uptake in the caudate and putamen, and putamen to caudate ratios, decreased with increasing Hoehn and Yahr stage. Our findings indicate that [123I]IPT SPET may be a useful technique to estimate the extent of nigrostriatal degeneration in PD patients. Close relationships between striatal [123I]IPT binding and clinical features of the disease suggest that this method can be used to objectively follow the course and progression of PD. The reduced putamen to caudate ratios observed even in patients with mild, newly recognized symptoms indicate that particularly this parameter may help to establish the correct diagnosis in the early course of PD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881814
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    In vivo effects of olanzapine on striatal dopamine D2/D3 receptor binding in schizophrenic patients: an iodine-123 iodobenzamide single-photon emission tomography study (1999)
    Springer
    European journal of nuclear medicine 26 (1999), S. 862-868 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Iodine-123 iodobenzamide ; Single-photon emission tomography ; Schizophrenia ; Olanzapine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Olanzapine is a new atypical antipsychotic agent that belongs to the same chemical class as clozapine. The pharmacological efficacy of olanzapine (in contrast to that of risperidone) has been shown to be comparable to that of clozapine, but olanzapine has the advantage of producing a less pronounced bone marrow depressing effect than clozapine. The specific aims of this study were (a) to assess dopamine D2/D3 receptor availability in patients treated with olanzapine by means of iodine-123 iodobenzamide [123I]IBZM single-photon emission tomography (SPET), (b) to compare the results with findings of [123I]IBZM SPET in patients under treatment with risperidone and (c) to correlate the results with the occurrance of extrapyramidal side-effects (EPMS). Brain SPET scans were performed in 20 schizophrenic patients (DSM III R) at 2 h after i.v. administration of 185 MBq [123I]IBZM. Images were acquired using a triple-head gamma camera (Picker Prism 3000 XP). For semiquantitative evaluation of D2/D3 receptor binding, transverse slices corrected for attenuation were used to calculate specific uptake values [STR–BKG]/BKG (STR=striatum; BKG=background). The mean daily dose of olanzapine ranged from 0.05 to 0.6 mg/kg body weight. The dopamine D2/D3 receptor binding was reduced in all patients treated with olanzapine. Specific IBZM binding [STR–BKG]/BKG ranged from 0.13 to 0.61 (normal controls 〉0.95). The decreased D2/D3 receptor availability revealed an exponential dose-response relationship (r=–0.85, P〈0.001). The slope of the curve was similar to that of risperidone and considerably higher than that of clozapine as compared with the results of a previously published study. EPMS were observed in only one patient, presenting with the lowest D2/D3 availability. The frequency of EPMS induced by olanzapine (5%) was considerably lower than the frequency under risperidone treatment (40%). Our findings suggest an exponential relationship between the daily dose of olanzapine striatal and decreased D2/D3 striatal binding availability. The results are consistent with the findings of in vitro experiments reporting a higher D2/D3 receptor affinity and a similar 5HT2 receptor affinity of olanzapine as compared with clozapine. Thus, the decreased tendency to induce EPMS at therapeutic doses is not due to the limited occupancy of striatal D2/D3 receptors in vivo. Patients are protected from EPMS by other intrinsic effects of the drug, i.e. the combination of both D2/D3 and 5HT2 receptor antagonism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050460
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  • 8
    Electronic Resource
    Electronic Resource
    A new principle to normalize plasma concentrations allowing single-sample clearance determinations in both children and adults (1992)
    Springer
    European journal of nuclear medicine 19 (1992), S. 511-516 
    Details
    ISSN: 1619-7089
    Keywords: Single-sample clearance determination in children ; Quantitative renal function ; Mercaptoacetyltriglycine clearance ; Normalization of plasma concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A sufficiently accurate quantification of renal function requiring only one plasma sample without an additional gamma-camera study has, until now, only been possible in adults. A new principle will be presented here allowing the universal application of known algorithms, regardless of the clearance substance used, by normalizing the plasma concentrations with respect to the individual body dimensions of the patients - for infants as well as for adults. In this respect, algorithms are developed for clearance determinations using technetium-99m mercaptoacetyltriglycine (99mTc-MAG3), which are based on steady-state studies as the reference. They allow the calculation of quantitative clearance values in infants, requiring only one blood sampling at any time between the 25th and the 40th min postinjection. The comparison with a combined camera/two-plasmasample technique performed in 46 children aged between 9 days and 14 years (mean 6.05 years) resulted in a standard error of 8.5% from the line of identity (r = 0.94). Moreover, this procedure also increases the accuracy of results in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185857
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  • 9
    Electronic Resource
    Electronic Resource
    Role of technetium-99m sestamibi scintimammography and contrast-enhanced magnetic resonance imaging for the evaluation of indeterminate mammograms (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 1221-1229 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Technetium-99m sestamibi scintimammography ; Contrast-enhanced magnetic resonance imaging ; Breast carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. This study evaluated and compared technetium-99m sestamibi scintimammography (SMM) and breast magnetic resonance imaging (MRI) results in patients with indeterminate mammograms to determine whether either technique can improve the sensitivity and specificity for the diagnosis of breast carcinoma. From 123 consecutive patients who underwent physical examination, mammography, SMM, and histopathologic confirmation, a subgroup of 82 patients presenting with indeterminate mammograms was studied. Sixty-eight patients underwent contrast-enhanced MRI. SMM results were scored on the basis of the intensity and pattern of sestamibi uptake. MRI images were scored on the basis of signal intensity increase after administration of contrast material as well as the enhancement pattern and speed of gadolinium uptake. The results obtained with the two techniques were compared and related to the final histopathologic diagnoses. Considering indeterminate findings as positive, the sensitivity of SMM was 79% and the specificity, 70%. MRI displayed a sensitivity of 84% and a specificity of 49%. When indeterminate results were considered negative, the sensitivity and specificity of SMM were 62% and 83%, respectively. MRI revealed a sensitivity and specificity of 56% and 79%, respectively. The calculated sensitivities and specificities demonstrate the diagnostic limitations of both SMM and MRI in the evaluation of patients with indeterminate mammographic findings. Due to the higher specificity, SMM may be the preferred modality in the evaluation of selected patients with breast abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050145
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  • 10
    Electronic Resource
    Electronic Resource
    Patterns of elevated free calcium and calmodulin activation in living cells (1992)
    [s.l.] : Nature Publishing Group
    Nature 359 (1992), S. 736-738 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We investigated two cellular events to test prevailing hypotheses, derived from solution biochemistry11'12, concerning calmodulin's role in calcium-linked activation of cell functions. First, we correlated calcium transients and MeroCaM activation during serum stimulation of quiescent cells to test ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/359736a0
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