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  • 1
    Electronic Resource
    Electronic Resource
    Alkaline Phosphatase in the Developing Bursa of Fabricius (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 6 (1977), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The ontogeny of alkaline phosphatase in the bursa of Fabricius was Studied by histochemical and biochemical methods. According to the quantitative determinations, the activity of alkaline phosphatase increased from the 11th to 17th day of incubation—that is, during the time of the lymphoid follicle formation in the developing bursa. The activity was localized in the mesenchymal tissue surrounding the lymphoid follicles. Testosterone given in ova prevented the appearance of alkaline phosphatase in the bursal mesenchyme but had no effect on the activity of the embryonic liver. In contrast, in ova treatment with cyclophosphamide had no effect on the alkaline phosphatase in the bursa. By using transplantation of embryonic bursal stem cells, it was further shown that, in contrast to cyclophosphamide, testosterone destroys the capacity of the bursa to serve as a differentiation site for the B-cell lineage. The results indicate that testosterone affects the stromal cells of the bursa, whereas cyclophosphamide destroys only the lymphoid population undergoing differentiation and leaves the bursal stroma intact.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1977.tb00383.x
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  • 2
    Electronic Resource
    Electronic Resource
    Allergy to various components of topical preparations in stasis dermatitis and leg ulcer (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 5 (1979), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients suffering from stasis dermatitis and leg ulcers (192) were found to give an allergic reaction in epicutaneous texts to one or more components of topical preparations in 69.2% of cases. The most common reactions were obtained with neomycin 34.0% and its component framycetin 31.2%, wool alcohols 22.9% balsam of Peru 21.4%, chlorquinaldon 16.7% bacitracin 13.1% chinoform 10.9% dequalin 9.9% formaldehyde 4.2% and parabens 3.6% The incidence of allergic reactions reflects local use of preparations containing various allergens as well sis their capacity to produce allergy. Allergy may in some CLISO interfere with effective topical therapy. Debrisan® dextran polymer heads were found to the suitable for treatment of ulcers of multiallergic patients without risk of contact allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1979.tb04806.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of histamine assay methods in measuring in vitro-induced histamine release in patients with allergic rhinitis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 44 (1989), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: histamine release tests using whole blood were applied in testing in vitro Type I birch allergic reaction in two patients with allergic rhinitis. Heparinized blood was incubated with varying dilutions of allergen for 30 min at + 37°C. After centrifugation of the blood, plasma was separated and the liberated histamine was analysed by histamine radio enzyme assay (REA), high performance liquid chromatography (HPLC) with postcolumn derivatization system or radio immuno assay (RIA), and the results obtained by these methods were compared. REA and HPLC gave similar results, while RIA gave somewhat higher values, but was less sensitive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1989.tb02269.x
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  • 4
    Electronic Resource
    Electronic Resource
    Serine proteinases in human cutaneous mastocytosis (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 363-366 
    Details
    ISSN: 1432-069X
    Keywords: Cutaneous mastocytosis ; Serine proteinases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The main chymotryptic and tryptic proteinases of human skin were found in high-salt extracts of human dermis. The levels of these enzymes were markedly increased in salt extracts of human cutaneous mastocytosis as compared to the levels found in extracts of involved skin from the same patients, human cutaneous hemangiomas, and normal human skin. These data suggest that the chymotryptic and tryptic proteinases of human skin are primarily of mast-cell origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418163
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  • 5
    Electronic Resource
    Electronic Resource
    Alpha-fluoromethylhistidine in the treatment of idiopathic cold urticaria (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 99-104 
    Details
    ISSN: 1432-069X
    Keywords: Cold urticaria ; Histamine ; Histamine synthesis, inhibition of ; Alpha-fluoromethylhistidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Alpha-fluoromethylhistidine (alpha-FMH), a new irreversible inhibitor of mammalian histidine decarboxylase, was tested in the treatment of idiopathic cold urticaria in 11 patients. In the initial trial with 50 mg b.i.d., a significant decrease (about 30%) in the total blood histamine level was found after 3 weeks of treatment but clinically there was no improvement in the symptoms of ten cold urticaria patients nor in the responses to the ice-cube test. In the second trial with three patients suffering from severe idiopathic cold urticaria, a higher dose of up to 500 mg b.i.d. of alpha-FMH for 3 weeks resulted in a marked decrease in the total blood histamine level as well as in an apparent inhibition of histamine synthesis in the skin previously exposed several times to cold water. The symptoms of cold urticaria and the responses in the ice-cube tests also decreased simultaneously. No clinical side effects nor changes in laboratory analysis were seen during the treatment with alpha-FMH. These results suggest that alpha-FMH may be useful in the treatment of severe cold urticaria especially in combination with histamine exhaustion of mast cells using cold water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426586
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  • 6
    Electronic Resource
    Electronic Resource
    Suction blister device with regulation of temperature: Demonstration of histamine release and temperature change in cold urticaria (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 317-321 
    Details
    ISSN: 1432-069X
    Keywords: Suction blister device ; Skin temperature regulation ; Cold urticaria ; Histamine release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the suction blisters. The skin temperature increases faster after the cold challenge period in cold urticaria patients than in normal control persons. This could be explained by vasodilatation and increased circulation in the skin, following the release of histamine in the cold urticaria reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404624
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  • 7
    Electronic Resource
    Electronic Resource
    Histologic characteristics of lichen planus transplanted onto nude mice and cultured in vitro (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 23-28 
    Details
    ISSN: 1432-069X
    Keywords: Lichen planus ; Nude mouse ; Organ culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice: the dense lymphocyte infiltrate in dermis disappeared, the basal cell layer normalized, and the colloid bodies disappeared from epidermis, although some of them were found in dermis. The granular layer also normalized, but the stratum corneum remained hyperkeratotic 6 weeks after transplantation. In organ culture, characteristic histologic features of lichen planus disappeared in 3–5 days via a rapid necrosis of the upper part of the epidermis and formation of a new, normal-looking basal epidermis. These results suggest that lesions of lichen planus are primarily dependent on the influence of the host to maintain their typical histologic appearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412684
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  • 8
    Electronic Resource
    Electronic Resource
    Immunoperoxidase and enzyme-histochemical demonstration of human skin tryptase in cutaneous mast cells in normal and mastocytoma skin (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 363-370 
    Details
    ISSN: 1432-069X
    Keywords: Skin tryptase ; Immunoperoxidase staining ; Mast cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Trypsin-like proteinase isolated from human skin was localized in cutaneous mast cells using immunoperoxidase and enzyme-histochemical techniques. Skin biopsy specimens were taken from four mastocytoma and four healthy patients. Immunoperoxidase staining was performed with protein A-sepharose purified rabbit polyclonal antibody raised against human skin tryptase and using aminoethylcarbazole as chromogen. The positively stained cells in the dermis were granular in character. Using peptide 4-methoxy-2-naphthylamide substrates (Bz-Arg-MNA, Z-Lys-Arg-MNA, Z-Gly-Arg-MNA, Z-Pro-Arg-MNA and Z-Gly-Pro-Arg-MNA) and Fast Garnet GBC as chromogen the red azo dye was found to precipitate in the cytoplasmic granules of the cutaneous mast cells. The enzymatic reaction was totally inhibited by diisopropyl fluorophosphate, leupeptin, and benzemidine. No marked inhibition was seen with soybean trypsin inhibitor and alpha-1-antitrypsin. The best substrate was Z-Gly-Pro-Arg-MNA giving the strongest red azo dye when incubation time was 15,30 or 60 min. These results show the localization of human skin tryptase in dermal mast cells and the usefullnes of Z-Gly-Pro-Arg-MNA as a suitable substrate tested for enzyme-histochemical localization of mast cells in healthy or mastocytoma skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426615
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