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  • 1
    Electronic Resource
    Electronic Resource
    Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases
    Amsterdam : Elsevier
    Clinica Chimica Acta 78 (1977), S. 465-471 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(77)90079-1
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  • 2
    Electronic Resource
    Electronic Resource
    Differential persistence, immunogenicity and protective capacity of temperature-sensitive mutants of Salmonella enteritidis after oral or intragastric administration to mice (1993)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 7 (1993), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract The persistence of Salmonella enteritidis temperature-sensitive (ts) mutants of different phenotypes in Peyer's patches (PP) and the spleen, and their immunogenicity after intragastric (i.g.) and peroral (p.o.) administration to mice was investigated. After p.o. administration the ts mutant C/2/2 colonized PP, but was not recovered from the spleen. After i.g. administration the ts mutant E/1/3 colonized both the spleen and PP. for at least 2 weeks. Mutant C/2/2 persisted in PP up to 8 days but was not found in the spleen. Mutant H/2/26, although it poorly colonized the PP, was recovered from the spleen up to day 15 after i.g. administration. Immunization with E/1/3 by either the i.g. or the p.o. routes protected mice from challenge with 100 LD50 of the virulent wild-type (wt) strain. Immunization with either C/2/2 or H/2/26 did not confer protection. The three ts mutants induced the production of local IgA after i.g. administration regardless of their protective capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.1993.tb00395.x
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  • 3
    Electronic Resource
    Electronic Resource
    Fts insertional mutant of Salmonella typhimurium (1995)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 132 (1995), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract A temperature-sensitive filamentation (fts) Salmonella typhimurium mutant was isolated after transposon mutagenesis with mini-Tn 10dTc. The mutant was unable to form colonies after 20 h incubation at 37°C on LB agar. Colonies appeared, however, after longer incubation at the restrictive temperature. Filamentation affected only part of the bacterial population. Rapid mapping using MudP22 hybrid phages revealed that the mutation, ftsD220, lies within minutes 68.5 and 73.6 on the genetic map. Further analysis revealed that the ftsD220 mapped at min 73 and that it is linked to cysG (6%) and to aroB (39%). Complementation tests suggested that the ftsD220 mutation is not homologous to a Escherichia coli ftsH mutation
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1995.tb07813.x
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  • 4
    Electronic Resource
    Electronic Resource
    A method to measure genetic distance between allogamous populations of alfalfa (Medicago sativa) using RAPD molecular markers (1998)
    Springer
    Theoretical and applied genetics 96 (1998), S. 406-412 
    Details
    ISSN: 1432-2242
    Keywords: Key words Medicago sativa ; RAPD ; Cultivars ; Genetic distance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Alfalfa (Medicago sativa L.) is a forage legume of world-wide importance whose both allogamous and autotetraploid nature maximizes the genetic diversity within natural and cultivated populations. This genetic diversity makes difficult the discrimination between two related populations. We analyzed this genetic diversity by screening DNA from individual plants of eight cultivated and natural populations of M. sativa and M.  falcata using the RAPD method. A high level of genetic variation was found within and between populations. Using five primers, 64 intense bands were scored as present or absent across all populations. Most of the loci were revealed to be highly polymorphic whereas very few population-specific polymorphisms were identified. From these observations, we adopted a method based on the Roger’s genetic distance between populations using the observed frequency of bands to discriminate populations pairwise. Except for one case, the between-population distances were all significantly different from zero. We have also determined the minimal number of bands and individuals required to test for the significance of between-population distances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050756
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  • 5
    Electronic Resource
    Electronic Resource
    Insight on segregation distortions in two intraspecific crosses between annual species of Medicago (Leguminosae) (1997)
    Springer
    Theoretical and applied genetics 94 (1997), S. 682-691 
    Details
    ISSN: 1432-2242
    Keywords: Key words Medicago truncatula ; Medicago tornata ; RAPD ; Segregation distortion ; DNA content
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  About 40% (α=0.05) of the PCR-derived markers scored in a Medicago truncatula and M. tornata intraspecific cross departed from Mendelian expectations at α=0.05. This proportion is among the highest ever documented in the literature, notably for intraspecific crosses. Estimations of DNA amount were also implemented for the parental genotypes or parental lines, and significant variations were observed. Our results suggest that the parental genotypes have diverged for quite a while, and we propose that the level of distortion we documented is correlated with the genome size difference we measured.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050466
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  • 6
    Electronic Resource
    Electronic Resource
    Localization of a symbiotic fix region on Rhizobium meliloti pSym megaplasmid more than 200 kilobases from the nod-nif region (1985)
    Springer
    Molecular genetics and genomics 199 (1985), S. 232-239 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have established the HindIII physical map of a cloned 290 kilobase fragment of the Rhizobium meliloti 2011 pSym megaplasmid. The cloned fragment, which contains nodulation genes as well as the nitrogenase structural genes (nifHDK), has been shown to be colinear with the corresponding genomic region. Using transposon mutagenesis we have demonstrated that a region which is located more than 200 kb from the nifHDK operon on pSym is essential for symbiotic nitrogen fixation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330264
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  • 7
    Electronic Resource
    Electronic Resource
    The diagnosis of amniotic fluid embolism: an immunohistochemical study for the quantification of pulmonary mast cell tryptase (1998)
    Springer
    International journal of legal medicine 111 (1998), S. 238-243 
    Details
    ISSN: 1437-1596
    Keywords: Key words Amniotic fluid embolism ; Mast cell tryptase ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract Recent clinical articles have suggested that amniotic fluid embolism (AFE) may be the result of anaphylactic reactions to fetal antigens and that the major part of this clinical syndrome is the result of mast cell degranulation and of the release of histamine, tryptase and other mediators. Tryptase, a neutral protease, is known to be the dominant protein component of the secretory granules of T and TC mast cells. In this paper we have examined the presence and the pulmonary distribution of mast cell tryptase utilizing specific immunohistochemical studies and morphometric evaluation in six cases of fatal amniotic fluid embolism compared to six subjects who died following anaphylactic shock and two control groups (five and six cases respectively) of traumatic death. The results demonstrate a numerical increase of pulmonary mast cells in the subjects who died of AFE (average cell number 54.095) with values corresponding to those encountered in cases of death due to anaphylactic shock (average cell number 51.378) compared with that of the traumatic control groups (average cell number 24.477 and 9.995 respectively). These results can shed light on additional criteria for the diagnosis of amniotic fluid embolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050160
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  • 8
    Electronic Resource
    Electronic Resource
    Evaluation of different temperature-sensitive mutant phenotypes ofSalmonella enteritidis as vaccine potentials (1990)
    Springer
    Current microbiology 21 (1990), S. 225-228 
    Details
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Temperature-sensitive (ts) mutants ofSalmonella enteritidis were isolated after mutagenesis with UV light and enrichment with antibiotic. Mutants were characterized according to their growth profile at the permissive (28°C) and the nonpermissive (37°C) temperatures, persistence of surface antigens, reversion frequencies, and potentials for inducing humoral immunity and protection against challenge with the parental wild-type (wt) in mice. We obtained 32 strains ofS. enteritidis able to grow well at 28°C, but capable of only limited or no replication at 37°C. The ts mutants were positive for factor 9 in an agglutination assay and were susceptible to infection with phage P22. Three mutants of different phenotypes were selected for protection studies. A single intraperitoneal (i.p.) immunization with any of the mutants studied induced significant protection from i.p. challenge with 100 LD50 of the wt strain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02092160
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  • 9
    Electronic Resource
    Electronic Resource
    Humoral immunity induced in the lower respiratory tract by local immunization with a temperature-sensitive mutant ofPseudomonas aeruginosa (1991)
    Springer
    Current microbiology 22 (1991), S. 265-269 
    Details
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The nature of the humoral immune mechanisms involved in the protection induced after local immunization with a temperature-sensitive (ts) mutant ofPseudomonas aeruginosa was investigated. We had previously shown that intranasal (i.n.) immunization of granulocytopenic mice protected the animals from lethal pulmonary challenge withP. aeruginosa, whereas mice immunized intraperitoneally were unprotected. Intranasal immunization induced high levels of anti-P. aeruginosa IgG and IgA in the lower respiratory tract, whereas only modest levels of IgG (and no IgA) could be detected in lung lavage fluids from mice immunized by the intraperitoneal (i.p.) route with ts mutant E/9/9. Plasma anti-P. aeruginosa IgG levels after i.n. immunization were lower than those observed after i.p. immunization with similar doses of the ts mutant. The main contribution to the protection induced when mice are immunized intranasally appears to be from IgA in the pulmonary secretions, although other immune mechanisms cannot be discounted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02092320
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  • 10
    Electronic Resource
    Electronic Resource
    Memory and executive functions in healthy subjects and patients with multiple sclerosis: the role of PET and SPECT (1998)
    Springer
    Neurological sciences 19 (1998), S. S403 
    Details
    ISSN: 1590-3478
    Keywords: Memory ; Executive functions ; PET ; SPECT Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Nonostante le molteplici ricerche, non è ancora ben chiaro il ruolo preciso delle differenti aree cerebrali nei processi mnesici ed attenzionali. L'uso di tecniche funzionali come la tomografia ad emissione di positroni (PET) e la tomografia ad emissione di singoli fotoni (SPECT) ha reso possibile valutare le singole diverse strutture the sono coinvolte in tali processi. In questo lavoro, abbiamo preso in considerazione gli study effettuati mediante PET e SPECT mirati ad approfondire il substrato neuroftsiologico alla base dei processi attenzionali. Per quanto riguarda la memoria, è stato esaminato il ruolo delle diverse aree corticali, con particolare riguardo alla corteccia frontale e temporale. Nell'umbito della sclerosi multipla, gli study funzionali hanno messo in luce l'importanza delle strutture sottocorticali per le funzioni mnesiche ed esecutive, contribuendo a chiarire il ruolo della disconnessione tra strutture corticali e sottocorticali.
    Notes: Abstract Despite extensive research, the precise role of different brain areas in modulating attentional and mnemonic processes is still controversial. Using positron emission tomography (PET) or single photon emission computed tomography (SPECT), we can measure changes which are associated with the level of neuronal activity in normal subjects and in patients. We describe the pattern of activation in attentional processes, with respect to three basic components: vigilance, selective attention and attentional processing capacity. Furthermore, we underline the predominant role of frontal and temporal cortices that mediate different activities associated with memory function. Functional techniques have substantially contributed to a better understanding of the cognitive deficits associated with multiple sclerosis (MS), suggesting that cortical- subcortical disconnection is the most likely cause of the neuropsychological deficits. The difficulties in attempting to attribute specific cognitive abnormalities to focal brain pathology in presence of widespread disease such as MS will probably be attenuated by functional neuroimaging studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539596
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