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  • 1
    Electronic Resource
    Electronic Resource
    In vitro suppression of UGA codons in a mitochondrial mRNA (1980)
    [s.l.] : Nature Publishing Group
    Nature 287 (1980), S. 361-363 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our choice of mRNA was based on two considerations. First, previous cell-free translation experiments had shown that up to 27% of the products synthesized under the direction of an 11-13S fraction of mtRNA is reactive with an antiserum against cytochrome c oxidase1'2. Transcript mapping shows that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/287361a0
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  • 2
    Electronic Resource
    Electronic Resource
    Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana (1999)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 402 (1999), S. 769-777 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996. Here we ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/47134
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  • 3
    Electronic Resource
    Electronic Resource
    RNA splicing in yeast mitochondria: DNA sequence analysis of mit − mutants deficient in the excision of introns aI1 and aI2 of the gene for subunit I of cytochrome c oxidase (1988)
    Springer
    Current genetics 13 (1988), S. 219-226 
    Details
    ISSN: 1432-0983
    Keywords: RNA splicing ; RNA maturase ; Cytochrome c oxidase subunit I ; Group II introns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have characterized two yeast mutants deficient in the splicing of transcripts of the mitochondrial gene for cytochrome c oxidase subunit I (coxI). Both map to the first intron (aI1). RNA blot analysis shows that in addition to a reduced (mutant M15-190) or blocked (mutant M12-193) excision of the mutated intron aI1, the mutants are unable to excise the adjacent aI2 intron, the reading frame of which displays an amino acid sequence similarity to all. Splicing of the downstream introns is not affected, however. Sequence analysis of the first mutant DNA (M12-193) reveals a premature termination of the intron-encoded open reading frame, followed by two alterations at a short distance downstream. The other (M15-190) contains 11 separate changes. Although these occur in the intron reading frame, their main effect on RNA splicing may be exerted through the disturbance of intron secondary structure proposed for the 5′ end of several group II introns. The implications of these findings in relation to maturase function and structure of intron aI1 are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387767
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of the gene encoding subunit II of yeast QH2: Cytochrome c oxidoreductase is regulated by multiple factors (1990)
    Springer
    Current genetics 17 (1990), S. 459-464 
    Details
    ISSN: 1432-0983
    Keywords: Yeast ; QH2: cytochrome c oxidoreductase ; Mitochondrial biogenesis ; Transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In Saccharmmyces cerevisiae, the COR2 gene codes for the 40 kDa subunit II of the QH2: cytochrome c oxidoreductase, an enzyme of the mitochondrial respiratory chain. Regions in the 5′ flank of this gene important for regulated expression were identified by assaying β-galactosidase activities in cells carrying different COR2-lacZ fusion genes. Sequences downstream of position-201 relative to the translational initiation codon are sufficient to confer regulation by carbon source, whereas sequences downstream of position-153 do not give rise to significant expression. A binding site for the abundant general transcription factor GFI is present in the region between-201 and-153 just upstream from sequences which resemble the consensus DNA recognition sequence of the regulatory protein complex HAP2/HAP3: 5′-TNATTGGT-3′. By quantitating RNA levels and assaying β-galactosidase activities we show that synthesis of COR2, which is not a hemoprotein, is regulated by HAP1, HAP2/HAP3 and heme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313072
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  • 5
    Electronic Resource
    Electronic Resource
    Editorial (1992)
    Springer
    Antonie van Leeuwenhoek 62 (1992), S. 1-1 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584457
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  • 6
    Electronic Resource
    Electronic Resource
    Genetic approaches to the study of mitochondrial biogenesis in yeast (1992)
    Springer
    Antonie van Leeuwenhoek 62 (1992), S. 131-153 
    Details
    ISSN: 1572-9699
    Keywords: mitochondrial DNA ; mutational analysis ; nucleo-mitochondrial interactions ; gene expression ; membrane assembly ; respiratory deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In contrast to most other organisms, the yeastSaccharomyces cerevisiae can survive without functional mitochondria. This ability has been exploited in genetic approaches to the study of mitochondrial biogenesis. In the last two decades, mitochondrial genetics have made major contributions to the identification of genes on the mitochondrial genome, the mapping of these genes and the establishment of structure-function relationships in the products they encode. In parallel, more than 200 complementation groups, corresponding to as many nuclear genes necessary for mitochondrial function or biogenesis have been described. Many of the latter are required for post-transcriptional events in mitochondrial gene expression, including the processing of mitochondrial pre-RNAs, the translation of mitochondrial mRNAs, or the assembly of mitochondrial translation products into the membrane. The aim of this review is to describe the genetic approaches used to unravel the intricacies of mitochondrial biogenesis and to summarize recent insights gained from their application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584467
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  • 7
    Electronic Resource
    Electronic Resource
    Small, beautiful and essential (1989)
    [s.l.] : Nature Publishing Group
    Nature 341 (1989), S. 569-571 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] HUMAN mitochondrial DNA (mtDNA) is remarkable both for its small size and for the immaculate economy of organization of the genes encoded by it1. Regarded by some as merely a relic of the event that brought a symbiotic bacterium into an ancestor of the eukaryotic cell, by others as a molecular ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/341569a0
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  • 8
    Electronic Resource
    Electronic Resource
    Molecular evolution: Deciphering divergent codes (1986)
    [s.l.] : Nature Publishing Group
    Nature 324 (1986), S. 109-110 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To evolutionary biologists the protists must appear a motley collection of organisms with diverse characters, defying simple classification, and with many unusual features whose original selective advantage can sometimes only be guessed at. The discovery last year1"5 that ciliate protozoa make use ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/324109a0
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  • 9
    Electronic Resource
    Electronic Resource
    Trailing the itinerant intron (1990)
    [s.l.] : Nature Publishing Group
    Nature 344 (1990), S. 110-111 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/344110a0
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  • 10
    Electronic Resource
    Electronic Resource
    Helping RNA catalysis along (1987)
    [s.l.] : Nature Publishing Group
    Nature 330 (1987), S. 313-314 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SINCE the pioneering work of Thomas Cech and his colleagues on the self-splicing reaction carried out by the precursor to the large ribosomal (r)RNA in the protozoan Tetrahymena, the principle of RNA catalysis has become a familiar one (see ref. 1 for a review). When incubated in a simple salt ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/330313a0
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