Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed (1996)
    Springer
    Current genetics 30 (1996), S. 206-211 
    Details
    ISSN: 1432-0983
    Keywords: Key words Multi-copy suppression ; Mitochondrial membrane ; Metalloprotease ; S. cerevisiae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The AFG3 gene of Saccharomyces cerevisiae encodes a mitochondrial inner membrane protein with ATP-dependent protease activity. To gain more insight into the function of this protein, multi-copy suppressors of an afg3-null mutation were isolated. Three genes were found that restored partial growth on non-fermentable carbon sources, all of which affect the biogenesis of respiratory competent mitochondria: PIM1(LON) encodes a matrix-localized ATP-dependent protease involved in the turnover of matrix proteins; OXA1(PET1402) encodes a putative mitochondrial inner membrane protein involved in the biogenesis of the respiratory chain; and MBA1 encodes a mitochondrial protein required for optimal respiratory growth. All three genes also suppressed a null mutation in a related gene, RCA1, as well as in the combination of afg3- and rca1-null.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050122
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The role of protein degradation in mitochondrial function and biogenesis (1996)
    Springer
    Current genetics 30 (1996), S. 367-380 
    Details
    ISSN: 1432-0983
    Keywords: Key words Mitochondrial proteases ; Protein turnover ; Proteolysis ; Chaperones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract It has been known for a long time that mitochondria contain their own protein-degradation systems. Only recently, however, have genes for mitochondrial proteases been identified and the powerful techniques of molecular biology been applied to gain insight into the role of protein degradation in mitochondrial biogenesis. It is now clear that the mitochondrial proteases that are involved in the initial stages of degradation are similar to prokaryotic ATP-dependent proteases, and that a division of labour exists between soluble and membrane-bound systems. These systems are essential for the biogenesis of fully functional mitochondria. Their natural targets are currently being identified, and their co-operation with chaperones and possible dual functions as chaperones/proteases are being investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050145
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mss51p, a putative translational activator of cytochrome c oxidase subunit-1 (COX1) mRNA, is required for synthesis of Cox1p in Saccharomyces cerevisiae (2000)
    Springer
    Current genetics 37 (2000), S. 213-220 
    Details
    ISSN: 1432-0983
    Keywords: Key words MSS51 ; Mitochondrial translation ; Yeast ; Cytochrome c oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Mutants of Saccharomyces cerevisiae that lack a functional MSS51 gene are respiratory deficient due to the absence of cytochrome c oxidase subunit 1 (Cox1p). It has been previously suggested, but not formally proven, that Mss51p is required for translational activation of COX1 mRNA, rather than being involved in a subsequent step in the synthesis of Cox1p or its assembly into cytochrome c oxidase. Pulse-chase labelling experiments now show that the absence of detectable levels of Cox1p in mss51-null strains is indeed due to the lack of synthesis of Cox1p, and is not caused by reduced stability of the protein. To gain more insight into the exact function of Mss51p, we determined the subcellular localization of the protein. We were able to show that an epitope-tagged version of Mss51p (Mss51HA) complements the mutation and can be localized in mitochondria, where it is firmly associated with the mitochondrial inner membrane. In addition, we characterized the previously identified mutant allele mss51-3. Sequence analysis revealed the presence of a short open reading frame upstream of MSS51 resulting from the creation of an extra ATG startcodon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050522
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Mitochondrial genes at Cold Spring Harbor (1981)
    Springer
    Current genetics 4 (1981), S. 167-171 
    Details
    ISSN: 1432-0983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The flowering dogwood trees and green lawns of Cold Spring Harbor provided the setting for a meeting devoted to Mitochondrial Genes from May 13-17th, 1981. Dedicated to the memory of Boris Ephrussi, who pioneered mitochondrial genetics at a time when the only kinds of genetics were nuclear or unclear, the meeting showed that the study of mtDNA has had impact on many areas of molecular biology including the genetic code and decoding, tRNA function, mechanisms of splicing and molecular evolution. Curiously, as Herschel Roman pointed out in his opening address, Ephrussi took great pains to avoid any mention of mitochondrial DNA in connection with his observations on cytoplasmic inheritance, preferring instead to refer to ‘cytoplasmic particles, endowed with genetic continuity’ (Ephrussi 1953). This reticence was not shared by participants at the meeting, as the following, brief report will show.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00420493
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Yeast mitochondrial RNA does not contain poly(A) (1974)
    [s.l.] : Nature Publishing Group
    Nature 252 (1974), S. 167-169 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Intact yeast mitochondria are difficult to isolate quickly from whole cells. Since rapid isolation should be a prerequisite for the characterisation of RNA pulse labelled for short periods, we preferred to pulse label isolated protoplasts. Using this system McLaughlin et al.5 have detected ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/252167a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana (1999)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 402 (1999), S. 769-777 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996. Here we ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/47134
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Molecular evolution: Deciphering divergent codes (1986)
    [s.l.] : Nature Publishing Group
    Nature 324 (1986), S. 109-110 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To evolutionary biologists the protists must appear a motley collection of organisms with diverse characters, defying simple classification, and with many unusual features whose original selective advantage can sometimes only be guessed at. The discovery last year1"5 that ciliate protozoa make use ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/324109a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Trailing the itinerant intron (1990)
    [s.l.] : Nature Publishing Group
    Nature 344 (1990), S. 110-111 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/344110a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Helping RNA catalysis along (1987)
    [s.l.] : Nature Publishing Group
    Nature 330 (1987), S. 313-314 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SINCE the pioneering work of Thomas Cech and his colleagues on the self-splicing reaction carried out by the precursor to the large ribosomal (r)RNA in the protozoan Tetrahymena, the principle of RNA catalysis has become a familiar one (see ref. 1 for a review). When incubated in a simple salt ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/330313a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    In vitro suppression of UGA codons in a mitochondrial mRNA (1980)
    [s.l.] : Nature Publishing Group
    Nature 287 (1980), S. 361-363 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our choice of mRNA was based on two considerations. First, previous cell-free translation experiments had shown that up to 27% of the products synthesized under the direction of an 11-13S fraction of mtRNA is reactive with an antiserum against cytochrome c oxidase1'2. Transcript mapping shows that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/287361a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...