Electronic Resource
Springer
Journal of neural transmission
53 (1982), S. 217-221
ISSN:
1435-1463
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Danitracen lowered serotonin levels in the cerebrum, cerebellum, medulla and the whole brain. The drug did not appear to affect the concentration of 5-HIAA except in the cerebellum where there was a considerable depletion. Danitracen pretreatment led to a lowering in the 5-HT levels in the various parts of the brain without influencing 5-HIAA levels in the whole brain and decreased NE levels in apomorphine and amphetamine-treated rats. The findings indicate that the mechanism of action of danitracen also involves noradrenergic neurons along with a possible increase in the metabolism of 5-HT.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01243413
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