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Digitale Medien

Neurochemical effects of danitracen (WA-355): Mechanism of action (1982)

Hrishi Keshavan, H. J. ; Gurbani, N. K. ; Dandiya, P. C.

Springer

Journal of neural transmission 53 (1982), S. 217-221

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Details

ISSN: 1435-1463

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Danitracen lowered serotonin levels in the cerebrum, cerebellum, medulla and the whole brain. The drug did not appear to affect the concentration of 5-HIAA except in the cerebellum where there was a considerable depletion. Danitracen pretreatment led to a lowering in the 5-HT levels in the various parts of the brain without influencing 5-HIAA levels in the whole brain and decreased NE levels in apomorphine and amphetamine-treated rats. The findings indicate that the mechanism of action of danitracen also involves noradrenergic neurons along with a possible increase in the metabolism of 5-HT.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01243413

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