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  • 1
    Electronic Resource
    Electronic Resource
    Undifferentiated (embryonal) sarcoma of the liver in an adult patient with metastasis of the heart and brain (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 209-212 
    Details
    ISSN: 1432-1440
    Keywords: Undifferentiated sarcoma ; Embryonal sarcoma ; Heart ; Brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 26-year-old woman with a tumor of the left liver lobe was admitted to the hospital. After incomplete resection of the tumor and histological diagnosis of an undifferentiated (embryonal) sarcoma of the liver a combination chemotherapy with ifosfamide and epidoxorubicine was started. 11 months later brain metastases were diagnosed. Routine ultrasound examination of the heart disclosed a pericardial tumor infiltrating the left atrium of the heart. After radiation therapy of the brain metastases the patient was treated with two cycles of high-dose ifosfamide and epidoxorubicin. Two years after diagnosis the patient developed signs of cardiac failure and died. Postmortem autopsy confirmed the local recurrence of the liver neoplasm and revealed its continuous spread to the pericardium via the diaphragm and infiltration of the left atrium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189313
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  • 2
    Electronic Resource
    Electronic Resource
    Chemotherapy of a patient because of spuriously elevated alpha-fetoprotein levels (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 408-412 
    Details
    ISSN: 1432-1440
    Keywords: Germ-cell tumor ; Variation, source of ; Human anti-murine antibody ; Immunoaffinity purification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Because of spuriously elevated alpha-fetoprotein levels, a course of polychemotherapy was given to a patient. We purified and identified the serum factor responsible for falsely high AFP levels as an IgG directed against mouse IgG. On gel filtration it behaves differently from true AFP, exhibiting a molecular weight of around 150,000. Chromatography on ‘Protein A-Sepharose’ revealed properties indistinguishable from those of IgG. The patient had never been treated with mouse antibodies, neither for diagnostic nor therapeutic purposes and he had had no contact with animals professionally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711270
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  • 3
    Electronic Resource
    Electronic Resource
    Multiple nodular foci in the liver associated with chronic hepatic porphyria after previous treatment of breast cancer (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 592-597 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; Chronic hepatic porphyria ; Focal liver lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary More than 7 years after the diagnosis and treatment of breast cancer (T1N1aM0), multiple nodular foci were observed in the liver of a 40-year-old woman at ultrasonographic examination. The lesions were confirmed by CT scan, but CT-guided liver biopsy revealed only non-specific alterations. At subsequent peritoneoscopic examination, bluish-brown foci were indeed visible on the liver surface, but guided liver biopsies again failed to corroborate the suspected metastases. Instead, histology showed mild portal fibrosis, moderate steatosis and siderosis of hepatocytes, as before. Only the intense red fluorescence of part of the biopsy material under Wood's light suggested the diagnosis of chronic hepatic porphyria or porphyria cutanea tarda, here presumably as a consequence of prolonged alcohol consumption. Subsequent porphyrin studies in urine, faeces and plasma yielded the typical constellation of latent porphyria cutanea tarda (chronic hepatic porphyria type C). The activity of erythrocyte uroporphyrinogen decarboxylase was normal, which argued against a genetic predisposition. After 1 year of strict alcohol abstinence and low-dose chloroquine treatment the “nodular foci” in the liver were no longer visible on ultrasonogram and CT scan; only proton-weighted NMR imaging (SE 1500/30) still showed ill-defined areas of higher signal intensity. The renal excretion of porphyrins had decreased considerably. The levels are now consistent with the diagnosis of subclinical chronic hepatic porphyria type A. Modern non-invasive imaging techniques are tremendously useful, but they have their pitfalls. Focal liver lesions may present serious diagnostic problems, especially when they are found in a patient with a history of carcinoma at an extrahepatic primary site. A rare example is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721687
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  • 4
    Electronic Resource
    Electronic Resource
    Nebenwirkungen der Polychemotherapie bei metastasierten Hodentumoren (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 257-261 
    Details
    ISSN: 1432-1440
    Keywords: Adverse effects ; Drug therapy ; Testicular neoplasms ; Critical care ; Hodentumoren ; Polychemotherapie ; Nebenwirkungen ; supportive Maßnahmen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 25 Patienten mit metastasierten, nicht-seminomatösen Hodentumoren wurden operiert und zytostatisch mit einer Kombination aus Velbe, Bleomycin, Cis-Platin und/oder Ifosfamid behandelt. In 22 Fällen konnte eine anhaltende Vollremission bei einer mittleren Beobachtungszeit von 23 Monaten erreicht werden. 2 Patienten verstarben durch einen rasch auftretenden Tumorprogreß an postoperativen Komplikationen nach Second-look-LA. Ein Patient erlag nach Chemotherapie einem septischen Schock. Die Morbidität dieser effektiven Chemotherapie darf nicht unterschätzt werden. Passagere Panmyelophtise, Anorexie, Alopezie und Hyperpigmentationen sind unvermeidbar. Schweres Erbrechen, Elektrolytentgleisung, hämorrhagische Cystitis, Anämie, Septikämien lassen sich durch supportive Maßnahmen reduzieren. Auftretende Septikämien sind durch eine geeignete Antibiotika-Kombination ohne zusätzlichen Tubulusschaden zu beherrschen. Schwerwiegende Dauerschäden insbesondere an Innenohr und Niere können vermieden werden.
    Notes: Summary 25 Patients with metastatic non-seminomatous testicular neoplasms were treated by surgery and cytostatic therapy using a combination consisting of Velban, Bleomycin, Cis-Platinum and/or Ifosfamid. In 22 patients this procedure induced a persistant complete remission with a mean observation time of 23 months. 2 patients died because of post-surgical complications after a second-look-lymphadenectomy. They suffered from rapidly progressive tumor disease. One patient died in a septicemia during chemotherapy. Our experience is that morbidity of an effective chemotherapy should not be underestimated. Transient bone marrow suppression, anorexia, alopecia and hyperpigmentation are unavoidable. However, severe vomiting, disturbed electrolyte metabolism, hemorrhagic cystitis, anemia and septicemia can well be managed by respective supportive care. Septicemia, for instance, may be treated with appropriate antibiotics without inducing tubular necrosis. Supportive measures also will avoid severe chronic defects of ear and kidney function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728345
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  • 5
    Electronic Resource
    Electronic Resource
    Alternatives to cyvadic-combination therapy of soft tissue sarcomas (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1160-1162 
    Details
    ISSN: 1432-1440
    Keywords: Soft tissue sarcomas ; Alternative chemotherapy ; Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The CYVADIC combination has been the preferred treatment for soft tissue sarcomas for the last 10 years. Other combinations of therapy are necessary because the remission rate achieved with CYVADIC is only thirty per cent. Alternative therapies for these tumours are combinations includingcis-platinum, ifosfamide, epipodophyllin and high-dose methotrexate. Our therapeutic results with combinations ofcis-platinum and ifosfamide are comparable to CYVADIC. However, side-effects such as nausea, vomiting and fatigue due tocis-platinum in the palliative treatment of these tumours are intolerable for many patients. A combination of adriamycin and ifosfamide, which exhibites a higher remission rate of 44% and lower toxicity than CYVADIC, is giving encouraging results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740591
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  • 6
    Electronic Resource
    Electronic Resource
    Alternatives to CYVADIC combination therapy of soft tissue sarcomas (1986)
    Springer
    Cancer chemotherapy and pharmacology 18 (1986), S. S20 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The CYVADIC combination has been the preferred treatment for soft tissue sarcomas for the last 10 years. Other combination therapies are necessary, because the remission rate achieved with CYVADIC is only 30%. Alternative therapies for these tumors are combinations includingcis-platinum, ifosfamide, epipodophyllin, and high-dose methotrexate. Our therapeutic results with combinations ofcis-platinum and ifosfamide are comparable to those achieved with CYVADIC. However, the side-effects, such as nausea, vomiting and fatigue, ofcis-platinum used in the palliative treatment of these tumors are intoler-able for many patients. A combination of adriamycin and ifosfamide, which leads to a higher remission rate of 44% and has lower toxicity than CYVADIC, is giving encouraging results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647444
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  • 7
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of melphalan during intermittent therapy of multiple myeloma (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 187-193 
    Details
    ISSN: 1432-1041
    Keywords: melphalan ; myelomas ; pharmacokinetics ; intermittent therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary During intermittent melphalan-prednisone therapy the area under the plasma concentration-time curve of melphalan increased by an average of 45% after oral or intravenous administration of the drug in myeloma patients during the initial three courses at six-week intervals. The rise in melphalan plasma concentrations could not be referred to an alteration in melphalan elimination, metabolism, erythrocyte/plasma partition ratio, or protein binding. A possible explanation could be that covalent binding sites of melphalan were successively saturated during intermittent treatment, resulting in higher drug concentrations during successive courses of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609251
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  • 8
    Electronic Resource
    Electronic Resource
    Reduction of infection frequency by intravenous gammaglobulins during intensive induction therapy for small cell carcinoma of the lung (1984)
    Springer
    Infection 12 (1984), S. 167-170 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 32 Patienten mit einem kleinzelligen Bronchialkarzinom erhielten eine intensive Induktions- (Chemo- und Radio-)Therapie. In einer randomisierten prospektiven Studie zur Wirksamkeit von Immunglobulinen für die Infektionsprophylaxe verglichen wir Patienten, die 30 g Immunglobuline i.v., in drei Dosen, pro Therapiezyklus erhielten (Gruppe A), mit einer Kontrollgruppe von Patienten (Gruppe B), die dieselbe antitumorale Therapie erhielten. Alle Patienten wiesen eine deutliche Beeinträchtigung der zellulären Immunantwort auf. Die IgG-Serumkonzentration in Gruppe A war signifikant höher als in Gruppe B. Bei Patienten, die intravenöse Immunglobulinprophylaxe erhielten, beobachteten wir signifikant weniger Infektionen während der gesamten Induktionstherapie als bei Patienten, die keine Immunglobuline erhielten.
    Notes: Summary Thirty-two patients with small cell carcinoma of the lung received intensive induction chemoradiotherapy. In a randomized prospective study, we compared the outcome of patients who received 30 g immunoglobulin i.v. divided into three doses per therapy course for infection prophylaxis (Group A) with patients undergoing the same anti-tumor therapy (Group B). All patients were prospectively randomized to one of two groups in order to evaluate the role of intravenous immunoglobulin therapy for infection prophylaxis. Group A received 30 g intravenous immunoglobulin during each course of chemotherapy. Group B was a control group that received identical chemoradiotherapy but did not receive any immunoglobulin therapy. All patients had a severely impaired cellular immune response. IgG serum concentrations were significantly higher in group A. Patients who received intravenous immunoglobulin had significantly fewer infections during the entire treatment period than patients who did not receive prophylactic treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01640891
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