ISSN:
1435-1463
Keywords:
L-Dopa
;
CPP
;
NMDA
;
antagonist
;
NBQX
;
AMPA antagonist
;
MPTP
;
common marmosets
;
locomotor activity
;
Parkinsonism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Degeneration of dopaminergic nigrostriatal neurons in Parkinson's disease results in an overactivity of excitatory glutamatergic projections from the subthalamic nucleus to the output nuclei of the basal ganglia resulting in rigidity and akinesia. In theory pharmacological blockade of these overactive systems should improve parkinsonian symptomatology. The selective AMPA-antagonist NBQX and the competitive NMDA-antagonist CPP are not effective in animal models of Parkinson's disease when given alone but ameliorate parkinsonian symptomatology and stimulate locomotor activity when co-administered with a threshold dose of L-Dopa. These synergistic effects are seen in the MPTP-treated (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) common marmoset and the rat with unilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra. Therefore competitive NMDA and non-NMDA antagonists may offer a new therapeutic strategy for the treatment of Parkinson's disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02259538
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