ISSN:
1432-1440
Keywords:
Azathioprine
;
Type 1 hypersensitivity
;
Gastrointestinal side effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We report the case of a 49-year-old patient with progressive sensomotor polyneuropathy who developed nausea, vomiting, and diarrhea after 21/2 months of azathioprine therapy. Administration of the drug was interrupted. These symptoms recurred immediately after rechallenge with azathioprine. A duodenal biopsy demonstrated a massive local eosiniphilia without peripheral blood eosinophilia. Cutane testing with azathioprine showed a positive type 1 reaction. We diagnosed a hypersensitive reaction type 1 in the duodenal mucosa on the basis of the histological features, the history, and the cutane reaction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01648893
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