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  • 1
    Electronic Resource
    Electronic Resource
    Syntheses and Properties of the First Octahedral Diorganonickel(IV) Compounds (1994)
    s.l. : American Chemical Society
    Organometallics 13 (1994), S. 2557-2559 
    Details
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/om00019a007
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  • 2
    Electronic Resource
    Electronic Resource
    Nanoscale fracture studies using the scanning force microscope (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 2485-2487 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present a variety of experiments concerning friction and fracture mechanisms using two-dimensional arrays of microfabricated nanotowers as templates. The scanning force microscope tip is used as a tool to apply well-defined forces to the surface of the patterned substrate. Force statistic measurements reveal information about the forces involved in the fracture process and the probability of fracture of selected towers. These methods are discussed in the context of nanometer-scale mechanisms. Using optimized parameters, a controlled removal of individual nanotowers and the ability to "write" predefined patterns on a nanometer scale can be achieved. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1367297
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  • 3
    Electronic Resource
    Electronic Resource
    Ligand-Induced C,C Coupling and C,C Bond Breaking in Diarylfulvene Complexes of Cobalt(0) (1995)
    s.l. : American Chemical Society
    Organometallics 14 (1995), S. 2725-2732 
    Details
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/om00006a019
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  • 4
    Electronic Resource
    Electronic Resource
    Deficient translocation of c-Rel is associated with impaired Th1 cytokine production in T cells from atopic dermatitis patients (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Experimental dermatology 14 (2005), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Decreased production of T helper type 1 (Th1) cytokines, such as interferon-γ (IFN-γ) or interleukin-2 (IL-2), is a hallmark of atopic diseases. While accessory signals from antigen-presenting cells may be missing, T cells themselves may be suppressed in their ability to produce substantial amounts of Th1 cytokines. We show, in this study, that T cell receptor (TCR)-activated T cells from atopic dermatitis (AD) patients proliferate less than control T cells and produce lower amounts of IFN-γ and IL-2, but comparable amounts of IL-4. Because mice lacking the nuclear factor kappa B (NF-κB) transcription factors – p65 or c-Rel – show reduced Th1, but undisturbed Th2 responses, we investigated the role of c-Rel and p65 for Th1 cytokine production in T cells from healthy and severe AD patients. TCR-activated primary T cells from healthy donors treated with c-Rel antisense oligonucleotides produced lower levels of IL-2 and IFN-γ and proliferated less efficiently than the corresponding control T cells. Moreover, transfection of primary T cells with c-Rel or p65 enhanced proliferation and production of IL-2 and IFN-γ. Nuclear extracts of activated primary T cells from AD donors bound weakly to NF-κB-specific oligonucleotides, compared to extracts from healthy control T cells. Western blotting studies revealed that nuclear, but not cytosolic, extracts from T cells of AD patients lacked significant amounts of c-Rel and p65. T cell clones derived from AD patients failed to sufficiently translocate c-Rel and p65 into the nucleus following activation. Thus, impaired nuclear translocation of c-Rel and p65 may determine an impaired Th1 cytokine response in AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2005.00241.x
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  • 5
    Electronic Resource
    Electronic Resource
    Kongenitales Auftreten juveniler Xanthogranulome (großknotige Form) (2000)
    Springer
    Der Hautarzt 51 (2000), S. 423-426 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Non-Langerhanszell-Histiozytose ; Juvenile Xanthogranulome ; Keywords Non-Langerhans-cell-histiocytosis ; Juvenile xanthogranulomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract An infant girl presented at birth with multiple, large nodular xanthogranulomas. Her monozygotic twin sister was not affected. The congenital tumors were up to 1.5 cm in diameter, done-shaped and mainly located on the head and the upper half of the body. Histologically the cells were characterized as CD68+ non-Langerhans histiocytes. Follow-up for 18 months showed no new tumors and regression of the existing ones. No extracutaneous manifestations were observed. Knowledge of the differential diagnosis, especially the group of Langerhans cell histiocytosis, is essential for prognosis estimation.
    Notes: Zusammenfassung Wir berichten über ein Mädchen mit auffallend vielen großknotigen kongenitalen Xanthogranulomen. Die eineiige Zwillingsschwester war erscheinungsfrei. Die bis zu 1,5 cm großen, halbkugeligen am Kopf und der oberen Körperhälfte lokalisierten Tumoren waren bei Geburt vorhanden und bestanden aus CD68+ histiozytären Non-Langerhanszellen. In einem Nachbeobachtungszeitraum von 18 Monaten traten keine neuen Tumoren auf, die bestehenden Tumoren zeigten Regression. Extrakutane Manifestationen bestanden nicht. Die differentialdiagnostische Abgrenzung vor allem gegenüber Langerhanszell-Histiozytosen ist unerläßlich zur richtigen Einschätzung der Prognose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050051145
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  • 6
    Electronic Resource
    Electronic Resource
    MPF components and meiotic competence in growing pig oocytes (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 38 (1994), S. 85-90 
    Details
    ISSN: 1040-452X
    Keywords: Meiosis ; p34cdc2 ; Cyclin B ; Histone H1 kinase ; Okadaic acid ; Phosphatase 1 and 2A ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Growing pig oocytes (≤90 μm in diameter) are unable to resume meiosis in vitro. The objective of our present experiments has been to identify the reasons for meiotic competence in these cells. By comparing histone H1 kinase activity in growing and fully grown oocytes we demonstrate that incompetence is associated with an inability to activate H1 kinase in growing oocytes. Immunoblotting was used to determine whether this kinase inactivity resulted from a lack of either p34cdc2 protein or B-type cyclin. The results established that each of these cell cycle molecules are present in comparable amounts in both growing and fully grown oocytes. In the third series of studies experiments were carried out in an attempt to induce p34cdc2 activation during growth. Treatment with okadaic acid, an inhibitor of phosphatase 1 and 2A known to stimulate and accelerate the transition into M-phase of the meiotic cycle in a number of different species, was able to induce p34cdc2 kinase activity and facilitated the G2- to M-phase in growing oocytes.We conclude that although growing oocytes in pigs have sufficient key cell cycle components for the G2 to M transition, they remain incapable of converting these components to active maturation-promoting factor (MPF) until growth is virtually completed. Inhibition of phosphatase 1 or 2A induces the formation of active MPF during growth by an as yet unidentified pathway. © 1994 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080380114
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  • 7
    Electronic Resource
    Electronic Resource
    Development of preimplantation rabbit embryos in uterine flushing-supplemented culture media (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 27 (1990), S. 216-223 
    Details
    ISSN: 1040-452X
    Keywords: In vitro culture ; uterine secretions ; rabbit blastocysts ; medium treatments ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The development of cultured rabbit preimplantation embryos grown in standard media (Ham's F-10 or BSM II supplemented with bovine serum albumin (BSA) or homologous serum) or in Ham's medium supplemented with uterine flushings was compared. The uterine flushings derived from donors of 0.5-6 years of age. Uterine flushing supplemented media were used natively or after treatments like sterilization by filtration, lyophilization, three times freezing/thawing, heat denaturation, dialysis, or ultrafiltration. Compared with in vivo controls, embryonic growth was substantially reduced during in vitro culture, demonstrably by smaller diameters and impaired cell proliferation (measured by thymidine incorporation). The growth retardation was more pronounced in blastocyts (recovered at day 4 post coitum [p.c.]) than in morulae (recovered at day 3 p.c.). Development in uterine flushing media was notably better than in standard media but did not comply with in vivo development. Highest thymidine incorporation was observed in media with increased concentrations of uterine secretions and after sequential supplementation of flushings from subsequent progestational stages. Advanced donor ages, heating up to 80°C, freezing, and lyophilizing did not affect incorporation data statistically significantly, whereas sterilization by filtration, ultrafiltration, and dialysis led to a significantly reduced thymidine incorporation in the cultured embryos. The positive effects of uterine flushing supplementation are attributed to the supply of components more adjusted to the needs of the cultured embryos and/or to a reduction of pathological effects in vitro like washing out of nutritive and regulatory components from the embryo into the surrounding culture medium.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080270306
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  • 8
    Electronic Resource
    Electronic Resource
    Syntheses and Structures of Molecular Diphenolatonickel Compounds Containing Trimethylphosphane Ligands (1998)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 1998 (1998), S. 621-627 
    Details
    ISSN: 1434-1948
    Keywords: Nickel ; Oxidation ; Phenols ; Structure ; Dynamic NMR spectroscopy ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction of substituted phenols and dioxygen with Ni(PMe3)4 yields the low-spin tetracoordinate diphenolatonickel compounds Ni(OAr)2(PMe3)2 [ArOH = 2-tert-butylphenol (1), 2-tert-butyl-4-methylphenol (2), 2-tert-butyl-6-methylphenol (3), 2,4-di(tert-butyl)phenol (4), 2-tert-butyl-4-methoxophenol (5), 2-chloro-4-tert-butylphenol (6), 2-isopropylphenol (7), 3-tert-butylphenol (8)]. As is revealed by variable temperature 1H- and 13C-NMR spectroscopy the complexes constitute a mixture of two isomers, each of which can be observed separately at lower temperatures when interconversion is slower. An additional 6-carbaldehyde function transforms the phenolate into a chelating ligand, giving rise to a high-spin hexacoordinate compound Ni(OAr)2(PMe3)2 (9). X-ray crystal-structure determinations of 2 and 3 show a trans square-planar structure, and that of 9 shows a trans octahedral arrangement of donor atoms P2O4. Bulky substituents in the 3- or 4-position, or non-demanding substituents in the 2-position, are less effective in stabilizing molecular diphenolatonickel complexes.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Intermediates and Side-Reactions in the Synthesis of Molecular Diphenolatonickel Compounds Containing Trimethylphosphane Ligands (1998)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 1998 (1998), S. 2027-2032 
    Details
    ISSN: 1434-1948
    Keywords: Nickel(0) ; Oxidation ; Phenols ; Structure ; Ion pairs ; Hydrogen bonds ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Admission of molecular oxygen to a solution containing Ni(PMe3)4 and substituted phenols (ArOH) affords bisphenolatonickel compounds trans-Ni(OAr)2(PMe3)2 [ArOH = 2-chlorophenol (1), 2-bromophenol (2), 2,4,6-trichlorophenol (3)]. In the absence of dioxygen the phenols reversibly protonate the nickel complex to form ionic compounds [NiH(PMe3)4]+ Y- containing hydrogen-bonded anions Y = [H2(2-Cl-C6H4O)3] (4), [H(2-OH-C6H4COO)2] (5). As a side-reaction, formal insertion of nickel to give 2-hydroxyphenylnickel compounds Ni(Ar′)X(PMe3)3 [Ar′ = 2-OH-C6H4; × = Br (6), I (7)], trans-Ni(Ar′)Cl(PMe3)2 [Ar′ = 2-OH-3,5-Cl2-C6H2 (8)] and trans-Ni(OAr)Cl(PMe3)2 [Ar = 2,4,6-Cl3-C6H2 (9)] is observed. An X-ray crystal structure determination of 1 shows a trans square planar arrangement of donor atoms, that of 6shows a distorted square pyramid, while 4 contains tetrahedral nickel cations with a delocalized hydrogen atom and triphenolate anions H2(ArO)3-.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Comet assay as a tool to screen for mouse models with inherited radiation sensitivity (2000)
    Springer
    Mammalian genome 11 (2000), S. 552-554 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Recent in vivo and in vitro data of patients analyzed for genetic susceptibility to radiation during cancer therapy have shown structural changes in the chromosomes to be prevalent both in the patients being treated and in their immediate family members. As structural changes in chromosomes frequently lead to activation of proto-oncogenes and elimination of tumor-suppressor genes, they represent important mechanisms for the initiation of DNA repair processes and tumorigenesis. With the exception of rare genetic syndromes such as AT (Ataxia telangiectasia) or NBS (Nijmegen Breakage Syndrome), the background for the inheritance of genetic susceptibility to radiation is unknown. Recently, a large-scale genetic screen of mouse mutants has been established within the German Human Genome Project (Hrabè de Angelis and Balling 1998). The goal of this ENU (ENU: ethylnitrosourea) mutagenesis screen is the generation of mutant mice that will serve as animal models for human diseases and genetic susceptibility. In order to fully utilize the potential of a genetic screen of this magnitude, in which exploration for genes responsible for genomic instability and radiation sensitivity is to occur, it is necessary to establish a simple assay system that is amenable to automation. Hence, we are using the single-cell gel electrophoresis (comet assay) to detect mouse mutants that display a genetic susceptibility to ionizing radiation. We have established the analysis parameters in the comet assay which are currently used to detect radiation-sensitive mouse mutants and to control the variance within the mouse population in the ENU screen. The assay can be used to isolate genes that are responsible for DNA repair and radiation sensitivity in mouse and human.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003350010106
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