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  • 1
    Electronic Resource
    Electronic Resource
    Elevation Of Striatal Interleukin-6 and Serum Corticosterone Contents In Mptp-Treated Mice (1999)
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 26 (1999), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Changes in the content of striatal interleukins (IL-1β and IL-6) and serum corticosterone in relation to deterioration of the dopaminergic system induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; a dopaminergic neurotoxin; 20 mg/kg i.p., four administrations/12 h) in C57BL/6J mice were investigated.2. Striatal dopamine, IL-1β, IL-6 and serum corticosterone were measured on days 1 and 7 post-MPTP.3. Dopamine depletion was more severe on day 7 than on day 1 post-treatment.4. Increases in IL-6 were observed on days 1 and 7 post-MPTP. The increase in striatal IL-6 content varied with the extent of dopamine depletion, although the IL-1β concentration remained unchanged compared with control values on days 1 and 7 post-treatment.5. Serum corticosterone was not different from control on day 1 post-MPTP. However, marked increases in the serum corticosterone were observed on day 7 post-treatment.6. These results suggest that changes in striatal IL-6 and serum corticosterone are closely associated with the severity of MPTP-induced dopaminergic degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.1999.03113.x
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  • 2
    Electronic Resource
    Electronic Resource
    SEX- AND AGE-RELATED CHANGES IN URINARY CONTENTS OF α1-MICROGLOBULIN AND ULINASTATIN IN MICE (1999)
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 26 (1999), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Using two murine strains, ICR/Jcl and senescence-accelerated-prone inbred mouse 1 (SAMP1), age-associated changes in urine indices (e.g. urine volume, creatinine contents, contents of α1-microglobulin (α1M) and ulinastatin (UT)) and the relation of urinary contents of α1M and UT were investigated.2. Sex-related differences in the indices were not observed in ICR nor in SAMP1 mice.3. Urine indices per 24 h of ICR mice at 6 and 14 months of age were higher than those at 3 months of age, although indices of SAMP1 mice did not change with ageing. Urinary contents of α1M and UT in ICR mice at 6 and 14 months of age were higher than those in SAMP1 mice. However, contents of α1M and UT expressed as the contents per creatinine did not differ between these two strains.4. In the relation between urinary contents of α1M and UT, a positive correlation was displayed both in ICR and SAMP1 mice, and the regression slope did not significantly differ with ageing in these two strains.5. These results suggest that ageing per se is not a factor which affects the relation of urinary contents of α1M and UT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.1999.03093.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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